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Dr. Mark A. Sheridan

Jordan A. Engberg Professor
Department of Biological Sciences
North Dakota State University
PO Box 6050, Dept. 2715
Fargo, ND 58108-6050

Tel: 701.231.8110
Fax: 701.231.7149
E-mail: mark.sheridan@ndsu.edu

Biography

Dr. Mark Sheridan is a Jordan A. Engberg Professor in the Department of Biological Sciences at North Dakota State University.  He previously served as the Director of the Regulatory Biosciences Cluster at NDSU (1991-2000) and the Director of the North Dakota Experimental Program to Stimulate Competitive Research (2000-2003).  He currently serves as the Director of the Cellular and Molecular Biology Program.  He was born in Fullerton, California and grew up and attended schools in Southern California, graduating from Dos Pueblos Senior High School in Goleta, California. He earned his bachelor's and master's degrees from Humboldt State University, Arcata, California, and his doctorate in zoology from the University of California--Berkeley.  Dr. Sheridan’s research on hormone biology has been supported by NSF, NIH, and USDA.  He has given scores of presentations at scientific meetings and has been a visiting professor at several universities around the world, including Brazil, Hong Kong, Japan, and Sweden.  He currently serves as an editor/associate editor for four scientific journals: Comparative Biochemistry and Physiology, Frontiers in Endocrinology, General and Comparative Endocrinology, International Journal of Endocrinology.  He has received several awards for his teaching and research and was a Fellow of both the Japan Society for the Promotion of Science and the Brazil International Scholar Program. Dr. Sheridan is active in professional organizations, university governance, and mentoring undergraduate and graduate students, post-doctorals, and faculty regarding their research education, proposal writing, grant project management, and research careers. Dr. Sheridan lives in Fargo, North Dakota.  He enjoys reading and various outdoor activities, including hiking, camping, and bicycling.

Curriculum vitae

Teaching Interests

As a faculty member at NDSU, I teach undergraduate and graduate courses and direct student research.  My main teaching interests are in the area of physiology and endocrinology.  I have taught courses in general biology, animal physiology, cell physiology, physiological ecology, endocrinology, and endocrine/neuroendocrine systems.  In my classes I encourage an interactive environment for learning up-to-date information, and I stress the experimental bases of fundamental principles and the development of critical thinking and writing skills. I believe that student learning is enhanced by research experience, and I have endeavored to involve numerous undergraduates in my research program.

 

Research Interests

My general research interests are in the area of comparative biochemistry/physiology/endocrinology and concern the hormonal regulation of growth, development, and metabolism of animals.  My laboratory uses physiological, biochemical, and molecular biological approaches, including genomics and proteomics, to systematically investigate the structure, biosynthesis, function, and evolution of regulatory peptides.  My current research is focused on three main areas: somatostatin signaling, growth regulation, and environmental endocrinology.

Recent Publications

Books

Sheridan, M.A. 1999.  Instructor=s Guide for Campbell=s Biology, 5th Edition.  Benjamin-Cummings, Menlo Park, CA.

Bunde, C., Kroll, W., Sheridan, M.A., and Wagle, J.  2008.  Study Guide for Biology: The Dynamic Science by Russell, Wolfe, Hertz, Starr and McMillan.  Thomson/Books-Cole, Belmont, CA.

Bunde, C., Kroll, W., Sheridan, M.A., and Wagle, J.  2011.  Study Guide for Biology: The Dynamic Science, 2nd Edition by Russell, Hertz, and McMillan.  Thomson/Books-Cole, Belmont, CA (in press).

 

Symposium Proceedings

McCormick, S., M. Sheridan, R. Patino and D. MacKinlay (editors).  1996.   The Physiology of Migratory Fish. American Fisheries Society.

Sheridan, M.A. and Sower, S.A. (editors).  2000.  A Tribute to Erika M. Plisetskaya: New Insights on the Function and Evolution of Gastroenteropancreatic Hormones.  American  Zoologist, Vol 40.

 

Book Chapters

Sheridan, M.A. and Harmon, J.S.  1994.  Adipose tissue.  In, Biochemistry and Molecular Biology of Fishes, Vol. 3 (edited by P. W. Hochochka and T. P. Mommsen), pp. 305-311. Elsevier, Amsterdam-New York.

Sheridan, M.A., Kittilson, J.D., Ehrman, M.M., and Moore, C.A.  1997.  Polygenic expression of somatostatin in rainbow trout.  In Advances in Comparative Endocrinology (S. Kawashima and S. Kikuyama, eds), pp291-294.  Monduzzi Editore, Bologna.

Sheridan, M.A., Ehrman, M.M., Melroe, G.T., and Kittilson, J.D.  2001.  Regulation of somatostatin expression.  In Perspectives in Comparative Endocrinology:Unity and Diversity (H.J.Th. Goos, R.K. Rastogi, H. Vaudry, and R. Pierantoni, eds), pp133-137.  Monduzzi Editore, Bologna.

Sheridan, M.A. and Caruso, M.A. 2011.  Pancreas—Including pancreatic Enzymes and Pancreatic Hormones.  In Encyclopedia of Fish Physiology: From Genome to Environment (S. Holmgren and C. Olsson, section eds), Elsevier, in press.

Sheridan, M.A. 2011.  Regulation of Growth and Feeding. In Fish Physiology: From Genome to Environment

 (A.P. Farrell and E.D. Stevens, section eds), Elsevier, in press.

 

Recent peer-reviewed journal articles (out of 126 refereed publications)

Melroe, G.T., Ehrman, M.M., Kittilson, J.D., and Sheridan, M.A.  2000.  Glucose regulates pancreatic preprosomatostatin I expression.  FEBS Let. 465: 115-118.

Ehrman, M.M., Melroe, G.T., Kittilson, J.D., and Sheridan, M.A. 2000.  The expression of  preprosomatostatin II mRNAs in the Brockmann Bodies of Rainbow trout, Oncorhynchus mykiss, is regulated by glucose.  Gen. Comp. Endocrinol. 118: 150-160.

Sheridan, M.A. and Sower, S.A.  2000.  A tribute to Erika M. Plisetskaya: New insights on the function and evolution of gastroenteropancreatic hormone.  Introduction to the symposium.  Am. Zool. 40: 161-164.

Sheridan, M.A., Kittilson, J.D., and Slagter, B.J.  2000.  Structure-function relationships of the signaling system for the somatostatin peptide hormone family.  Am. Zool. 40:269-286.

Holloway, A.C., Melroe, G.T., Ehrman, M.M., Reddy, P.K., Leatherland, J.F., and Sheridan, M.A.  2001.  Effect of 17β-estradiol on the expression of somatostatin genes in rainbow trout (Oncorhynchus mykiss).  Am. J. Physiol., 279: R389-R393.

Alexander, L., Knutson, D., Kittilson, J.D., and Sheridan, M.A.  2001.  Localization of somatostatin mRNAs in the brain and pancreas of rainbow trout (Oncorhynchus mykiss).  Comp. Biochem. Physiol B. 129: 221-228.

Mercure, F., Holloway, A.C., Sheridan, M.A., Tocher, D.R., Van Der Kraak, G., and Leatherland, J.F.  2001.  Influence of plasma lipid changes in response to 17β-oestradiol-stimulation on plasma growth hormone, somatostatin, and thyroid hormone levels in immature rainbow trout.  J. Fish Biol. 59: 605-615.

Very, N.M., Knutson, D., Kittilson, J. and Sheridan, M.A.  2001.  Somatostatin inhibits the growth of rainbow trout.  J. Fish Biol. 59: 157-165.

Kao, Y.-H., Youson, J.H., Holmes, J.A., and Sheridan, M.A.  2002.  Effects of somatostatins and insulin on blood glucose levels of larvae and metamorphosing landlocked sea lamprey, Petromyzon marinus. Zool. Sci.  18: 1113-1116.

Lacy, E.L., Sheridan, M.A., and Moore, M.C.  2002.  Sex differences in lipid metabolism during reproduction in free-living lizards (Urosaurus ornatus).  Gen. Comp. Endocrinol. 128: 180-192.

Kao, Y.-H., Youson, J.H., Vick, B., and Sheridan, M.A.  2002.  Differences in the fatty acid composition of larvae and metamorphosing sea lamprey, Petromyzon marinus.  Comp. Biochem. Physiol. B 131:153-169.

Kao, Y.-H., Manzon, R.G., Sheridan, M.A., Leatherland, J.F., Holmes, J.A., and Youson, J.H.  2003.  Effect of alloxan and insulin immunoneutralization on circulating thyroid hormones levels in larval landlocked sea lamprey, Petromyzon marinus.  Zool. Sci. 20:635-638.

Ehrman, M.M., Moore, C.A., Kittilson, J.D., Eilertson, C.D., and Sheridan, M.A.  2003.  Nutritional regulation of somatostatin expression in rainbow trout, Oncorhynchus mykiss.  Fish Physiol. Biochem. 26: 309-314.

Ehrman, M.M., Melroe, G.T., Kittilson, J.D., and Sheridan, M.A.  2004.  Glucose-stimulated somatostatin gene expression in the Brockmann bodies of rainbow trout (Oncorhynchus mykiss) results form increased mRNA transcription and not from altered mRNA stability.  Zoo. Sci. 21:87-91.

Melroe, G.T., Ehrman, M.M., Kittilson, J.D., and Sheridan, M.A.  2004.  Growth hormone and insulin-like growth factor-1 regulate the expression of preprosomatostatin mRNAs in the Brockmann bodies of rainbow trout, Oncorhynchus mykiss.  Gen. Comp. Endocrinol. 136: 353-359.

Slagter, B.J. and Sheridan, M.A. 2004.  Differential expression of two somatostatin receptor subtype 1 mRNAs in rainbow trout (Oncorhynchus mykiss). J. Mol. Endocrinol. 32:165-177.

Sheridan, M.A. and Kittilson, J.D.  2004.  The role of somatostatins in the regulation of metabolism in fish.  Comp. Biochem. Physiol. B 138: 323-330.

Very, N.M and Sheridan, M.A.  2004.  The role of somatostatins in the regulation of growth in fish. Fish Physiol. Biochem., 27: 217-226.

Gong, J.-Y., Kittilson, J.D., Slagter, B.A. and Sheridan, M.A.  2004.  The two subtype 1 somatostatin receptors of rainbow trout, Tsst1A and Tsst1B, possess both distinct and overlapping ligand binding and agonist-induced regulation features.  Comp. Biochem. Physiol. 138: 295-303.

Slagter, B.J., Kittilson, J.D., and Sheridan, M.A.  2004.  Somatostatin receptor subtype 1 and subtype 2 mRNA expression is regulated by nutritional state in rainbow trout (Oncorhynchus mykiss).  Gen. Comp. Endocrinol. 139: 236-244.

Slagter, B.J., Kittilson, J.D., and Sheridan, M.A.  2005.  Expression of somatostatin receptor mRNAs is regulated in vivo by growth hormone, insulin, and insulin-like growth factor-1 in rainbow trout (Oncorhynchus mykiss).  Regul. Petptides 128: 27-32. 

Very, N.M., Kittilson, J.D., Norbeck, L.A., and Sheridan, M.A.  2005.  Isolation, characterization, and distribution of two cDNAs encoding for growth hormone receptor in the rainbow trout.  Comp. Biochem. Physiol. 140:615-628.

Nelson, L.E. and Sheridan, M.A.  2005.  Regulation of somatostatins and their receptors in fish.  Gen. Comp. Endocrinol. 142: 117-133.

Ehrman, M.M., Melroe, G.T., Kittilson, J.D. and Sheridan, M.A.  2005.  Regulation of somatostatin gene expression by insulin and glucagon in the endocrine pancreas of rainbow trout, Oncorhynchus mykiss.  Mol. Cell. Endocrinol.  235: 31-37.

Nelson, L.E. and Sheridan, M.A. 2006.  Gastroenteropancreatic hormones and metabolism in fish.  Gen. Comp. Endocrinol. 148: 116-124.

Nelson, L.E. and Sheridan, M.A. 2006.  Insulin and growth hormone stimulate somatostatin receptor (SSTR) expression by inducing transcription of SSTR mRNAs and by up-regulating cell surface SSTRs.  Am. J. Physiol. 291: R163-R169.

Poppinga, J., Kittilson, J., and Sheridan, M.A.  2006.  Changes in the expression of preprosomatostatin and somatostatin receptor mRNAs following seawater transfer and somatostatin-14 injection of rainbow trout (Oncorhynchus mykiss).  Trend. Comp. Biochem. Physiol. 12: 13-19.

Very, N.M. and Sheridan, M.A.  2007.  Somatostatin regulates hepatic growth hormone sensitivity by promoting internalization of growth hormone receptors and by decreasing transcription of growth hormone receptor.  Am. J. Physiol. 292: R1956-R1962.

Norbeck, L.A., Kittilson, J.D., and Sheridan, M.A.  2007.  Resolving the growth-promoting and metabolic effects of growth hormone: differential regulation of GH-IGF-I system components.  Gen. Comp. Endocrinol. 151: 332-341.

Very, N.M. and Sheridan, M.A. 2007.  Somatostatin inhibits insulin-like growth factor-I receptor expression in the gill of a teleost fish (Oncorhynchus mykiss).  FEBS lett. 581: 4773- 4777.

Poppinga, J, Kittilson, J., McCormick, S.D., and Sheridan, M.A. 2007.  Effects of somatostatin on the growth hormone-insulin-like growth factor-1 axis and seawater adaptation of rainbow trout (Oncorhynchus mykiss).  Aquaculture 273: 313-319.

Very, N.M., Kittilson, J.D., Klein, S., and Sheridan, M.A.  2007.  Somatostatin inhibits basal and growth hormone-stimulated insulin-like growth factor-I production.  Mol. Cell. Endocrinol. 281: 19-26.

Very, N.M., Kittilson, J.D., Klein, S., Sheridan, M.A.  2008.  Somatostatin inhibits basal and growth hormone-stimulated insulin-like growth factor-I production.  Mol. Cell. Endocrinol. 281: 19-26.

Caruso, M.A., Kittilson, J.D., Raine, J., Sheridan, M.A.  2008.  Rainbow trout (Oncorhynchus mykiss) possess two insulin-encoding mRNAs that are differentially expressed. Gen. Comp. Endocrinol. 155: 695-704.

Klein, S.E. and Sheridan, M.A.  2008.  Somatostatin signaling and the regulation of growth and metabolism in fish.  Mol. Cell. Endocrinol. 286: 148-154.

Hagemeister, A.L. and Sheridan, M.A. 2008.  Somatostatin inhibits hepatic growth hormone receptor and insulin-like growth factor-1 expression by activating the ERK and PI3 kinase signaling pathways.  Am. J. Physiol. 295: R490-R497.

Malkuch, H., Walock, C., Kittilson, J.D., Raine, J., Sheridan, M.A. 2008.  Differential expression of preprosomatostatin- and somatostatin receptor-encoding mRNAs in association with the growth hormone-insulin-like growth factor system during embryonic development of rainbow trout (Oncorhynchus mykiss).  Gen. Comp. Endocrinol. 159: 136-142.

Reindl, K.M., Kittilson, J.D., Sheridan, M.A. 2009.  Differential ligand binding and agonist-induced regulation characteristics of the two rainbow trout growth hormone receptors, GHR1 and GHR2, in transfected cells. J. Endocrinol. 202:463-471.

Hanson, A., Poudyal, D. Hagemeister, A., Sheridan, M.A. 2009.  Somatostatin inhibits insulin-like growth factor-1 receptor mRNA expression in rainbow trout gill by activating the ERK and PI3K signaling pathways.  Mol. Cell. Endocrinol. 315:57-62

Hagemeister, A.L and Sheridan, M.A.  2010.  Somatostatin and somatostatin receptors in fish growth.  Gen. Comp. Endocrinol.167:360-365.

Hagemeister, A.L., Kittilson, J.D., Bergan, H.E., Sheridan, M.A.  2010.  Rainbow trout somatostatin receptor subtypes SSTR1A, SSTR1B, and SSTR2 differentially activate the ERK and PI3K signaling pathways in transfected cells.  J. Mol. Endocrinol. 45:317-327.

Caruso, M.A., Blaufuss, P.C., Kittilson, J.D., Raine, J., Sheridan, M.A. 2010.  Isolation and characterization of a mRNA encoding a novel insulin receptor (IR) subtype, IR2, from rainbow trout (Oncorhynchus mykiss) and patterns of expression of the four IR subtypes, IR1-IR4, in tissues and during embryonic development.  Gen. Comp. Endocrinol. 169: 258-268.

Kittilson, J., Reindl, K., Sheridan, M.A. 2011.  Rainbow trout (Oncorhynchus mykiss) possess two hormone-sensitive lipase-encoding mRNAs that are differentially expressed and independently regulated by nutritional state.  Comp. Biochem. Physiol. 158A: 52-60.

Kao, Y-. H., Holmes, J.A., Youson, J.H., Sheridan, M.A. 2011.  The influence of acclimation temperature on the lipid composition of the larval lamprey, Petromyzon marinus, depends on the tissues and lipid classes.  Zool. Sci. 27: 835-841.

Reindl, K. Kittilson, J., Bergan, H., Sheridan, M.A. 2011.  Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK, PI3K-AKT, and JAK-STAT.  Am. J. Physiol. 301: R236-R243.

Norbeck, L.A. and Sheridan, M.A. 2011. An in vitro model for evaluating the peripheral regulation of growth in fish: Effects of 17β-estradiol and testosterone on the expression of growth hormone receptors, insulin-like growth factors, and insulin-like growth factor type 1 receptors in rainbow trout (Oncorhynchus mykiss).  Gen. Comp. Endocrinol. 173: 270-280.

Caruso, M.A. and Sheridan, M.A. 2011. New insights into the signaling system and function of insulin in fish.  Gen. Comp. Endocrinol. 173: 227-247.

Kittilson, J.D., Slagter, B.A., Martin, L., and Sheridan, M.A. 2011.  Isolation, characterization, and distribution of somatostatin receptor subtype 2 (SSTR2) mRNA in rainbow trout (Oncorhynchus mykiss), and regulation of its expression by glucose.  Comp. Biochem. Physiol.  160A: 237-247.

Kittilson, J., Jones, E. and Sheridan, M.A. 2011.  The ERK, PI3K/Akt, and JAK-STAT pathways are differentially activated by the two growth hormone receptor subtypes of a teleost fish (Oncorhynchus mykiss).  Front. Endocrinol. 2(30)1-7

Hanson, A., Kittilson, J.D., McCormick, S.D., Sheridan, M.A. 2011.  Effects of 17β-estradiol, 4-nonylphenol, and β-sitosterol on the growth hormone-insulin-like growth factor system and seawater adaptation of rainbow trout (Oncorhynchus mykiss).  Aquaculture, in press.

Reindl, K. and Sheridan, M.A. 2011.  Peripheral regulation of the growth hormone/insulin-like growth factor system in fish and other vertebrates.  Aquaculture International, in press.

Caruso, M.A. and Sheridan, M.A. 2011.  The expression of insulin and insulin receptor mRNAs is regulated by nutritional state and glucose in rainbow trout (Oncorhynchus mykiss).  Gen. Comp. Endocrinol., in press.

Bergan, H.E., Kittilson, J.D., and Sheridan, M.A. 2011.  Nutrition-regulated lipolysis in rainbow trout (Oncorhynchus mykiss) is associated with alterations in the ERK, PI3K-Akt, JAK-STAT, and PKC signaling pathways.  Gen. Comp. Endocrinolo., in press.


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Last Updated: Wednesday, October 26, 2011 11:06:38 AM