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Gudrun Lukat-Rodgers

Bioinorganic Chemistry

Heme proteins play an important role in many biological processes. Three types of heme proteins are under inves-tigation in my research. The first class includes proteins like heme-binding protein A which is important in heme sequestering in Haemophilus influenzae. The second class is catalase-peroxidases, in particular, Mycobacterium tuberculosis KatG which is necessary for the activation of the antitubercular drug isonazid against tuberculosis. The third class is heme-based sensor proteins which are responsible for monitoring the presence of small mole-cules (like O2, CO or NO) and initiating the appropriate response. Spectroscopic techniques, like resonance Raman, UV-visible absorbance and electron spin resonance, along with reaction kinetics, followed by transient absorbance, are used to probe the structure function relationships in these various heme proteins.

Selected Publications

G. S. Lukat-Rodgers, N. L. Wengenack, F. Rusnak and K. R. Rodgers, “Spectroscopic Comparison of the Heme Active Sites in WT KatG and its S315T Mutant,” Biochemistry 2000, in press (published on www).

G. S. Lukat-Rodgers, L. Tang and K. R. Rodgers, “Nitrosyl adducts of FixL as Probes of Heme Environment,” Journal of Biological Inorganic Chemistry 2000, in press. K. R. Rodgers, G. S. Lukat-Rodgers and L. Tang, “Spectroscopic Observation of a FixL Switching Intermediate,” J. Am. Chem. Soc. 1999, 121, 11241-11242.

G. S. Lukat-Rodgers, J. L. Rexine and K. R. Rodgers, “Heme Speciation in Alkaline Ferric FixL and Possible Tyrosine Involvement in the Signal Transduction Pathway for Regulation of Nitrogen Fixation.” Biochemistry 1998, 37, 13543-13552.

G. S. Lukat-Rodgers and K. R. Rodgers, “Characterization of Ferrous FixL Nitric Oxide Adducts by Resonance Raman Spectroscopy,” Biochemistry 1997, 36, 4178-4187.

 

Research Professor

PhD, Iowa State University, 1985
Postdoctoral Fellow, University of Iowa, 1985-1988
Postdoctoral Fellow, Princeton University, 1989-1993

Office: 363 Dunbar

tel 701-231-8834
fax 701-231-8831

Gudrun.Lukat-Rodgers@ndsu.edu