
There is no guaranteed answer to this question, though guidelines can be found from several sources.
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Top Ten Guidelines for Homepage Usability, all of which can be accomplished within the CMS framework. See the Top Ten page for details of what each guideline means. Suggestions for accomplishing each guideline using TYPO3 is listed below.
This requires no special techniques. Simply be sure to include this tagline in a visible content element somewhere in the page. Don't forget to follow Jakob's suggestion to make this tagline contain something that sets you apart rather than state the obvious.
For example, an article was recently published in "It's Happening At State," indicating that NDSU Pharmacy research ranks 13th nationally. I was very surprised to not see on the College of Pharmacy home page or on any sub-sites of the College of Pharmacy, as this is an excellent detail that sets NDSU Pharmacy apart.
In CMS, page titles are automatically generated from the Pagetitle field in Page properties.
The example below shows the window title for the CMS Knowledge
base page. Note that some browsers may also display the window
title as a tab label.

The recommended location is to use the URL www.ndsu.edu/yoursite/about/
This is already taken care of for you in the template.
Navigation link names come from the Pagetitle by default (or the Navigation Title, if provided). You might argue that URLs aren't how you like if you follow this guideline but it isn't so! In page properties, you can customize the URL, separate from the navigation link name.
The news application manages this automatically by displaying a few articles on the main page (optionally) and includes a link to the news archive.
For other announcements featured on your home page, it is easy to move the content to a deeper page by
Would you put pink flamingos in your front yard while trying
to sell your house? Do you think it would be a selling point for
your house to have pink lawn flamingos?
Why would you add unexpected "unique" flair to your organization's home page if it doesn't add value or provide meaning? The home page is valuable real estate, so don't waste space with distracting pictures.