Characterization of Anti-infective Coatings for Biomedical and Environmental Applications

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Researchers at NDSU have developed a suite of novel antifouling coatings based on contact active or non-leaching technologies. The primary reason for developing these types of coating systems was to prevent the unwanted accumulation of sea life on surfaces and structures immersed in the marine environment, with a particular emphasis on ship hulls. A logical extension of this technology would be the development of anti-infective coatings for a variety of biomedical and environmental applications, including antimicrobial protection for medically implanted devices (i.e., urinary catheters, tracheal tubes, wound dressing, stents etc.) and protection of military personnel and infrastructure (i.e., uniforms, vehicles, tents, etc.) from biological warfare agents. A suite of high-throughput assays are currently being developed at NDSU to rapidly characterize coatings for these types of applications.

Characterization of Anti-mold Properties

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Mold contamination or infestation of buildings, vehicles, ships and other structures located in areas or regions of high humidity is a major concern and health hazard. Once established on these surfaces, molds can produce toxins that can cause illnesses in people. A high-throughput screening assay has been developed at NDSU, using the multi-well plate technology, to rapidly assess the anti-mold properties of coating arrays. The semi-automated aerosol delivery apparatus, utilized for the delivery of spores and vegetative cells to self-decontaminating coatings, is used to apply aqueous suspensions of Aspergillus niger mold spores to coated discs placed on nutrient agar in multi-well plates. The coatings are inspected for visual growth (i.e., black color) after several days of incubation in a high humidity environment (>85%) to ascertain anti-mold properties.