Somatic Cells

Now the cycle starts again. One somatic cell has a duplicate and the other somatic cell has a deficiency.

Suppose one homologue carries a dominant allele while the other homologue carries a recessive allele. Somatic cells with the deficiency would appear as homozygous recessive phenotypes when the broken end previously had carried the dominant allele.

“Some tissues could be totally recessive - that is, abc. In this case, all three genes would be lost from a nucleus in a single anaphase break. Other tissues could be recessive for a but variegated for b and c. In this case A would be lost from the cell following one anaphase break, while B and C would be subsequently lost; (1) abc where B and C have subsequently and simultaneously been lost; (2) a b C from which B and not C has been lost. . . . No tissues should be found which show the genetic constitution a B c. In other words, when variegation within variegation is present, the development pattern should show the loss of terminal genes before loss of genes close to the centromere.”