Combining Linkage From Different Families

Example

Example

From Kramer and Burnham (1947).

We have two types of data, F coupling and F repulsion.

classes A_B_ A_bb aaB_ aabb
Observed Repulsion 753 292 351 19
Observed Coupling 1064 223 259 218

We can combine estimates from the product of M.L. methods. The method of maximum likelihood was used to obtain the estimates of p from each type of family.

Source Of Data value n pI
F repulsion 0.245 1.1555 1415 1635.0 398.94
F coupling 0.318 2.9279 1764 5164.8 1642.41

combined p value by weighting =

= 398.94 + 1642.41
= 1635.0 + 5164.8

= 2041.35
= 6799.80

= 0.3002

The standard error of this combined is:

Copyright 2000©, Ted Helms

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