Likelihood Ratio Test For Discrete Classes

LOD Score

Example

Varying Q

Maximum Likelihood: Testcross Data

Plotting Lod Scores

Homework Assignment # 8 Questions

Homework Assignment #8 Answers

Homework Assignment #8

Answers

  1. a) P(2/R) = P(2 and R) = (1/260) =  1 
                         P(R) R) = (1/260) = 10

    b) The sample space has been reduced to ten
    b) cars instead of 260 cars.

  2. The sample space is reduced when heterozygous and homozygous recessive marker genotypes can be discarded. Selecting only MM genotypes increases the probability of identifying QQ genotypes due to coupling linkage between M and Q.

  3. As recombination between the marker and QTL increases, the conditional probability of Q given M decreases. Fewer individuals that have a given marker genotype will have the favorable QTL genotype as recombination increases.

  4. If marker means are held constant, the recombination fraction can be varied, which changes the means of each QTL class. This is because there are three independent equations, one for each marker class, and four unknown parameters which include u1, u2, u3, and r.

Copyright 2000©, Ted Helms

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