Percent Recombinant Genotypes versus Map Distance

Haldane's Mapping Function

Example I

Summarizing

Example II

Expected Frequency Example I

Expected Frequency Example II

Poisson Distribution

An Example

Kosambi's Map Function

Summary Of Map Distance Versus Observed Recombination Fraction

Homework Assignment #7 Questions

Homework Assignment #7 Answers

Expected Frequency Example II

Let r = r = 0.2

  Expected Frequency
Genotype with double crossover without double crossover
AaBbCc 0.32 1/2(0.6) = 0.3
AaBbcc 0.08 1/2(0.2) = 0.1
AabbCc 0.02 0
Aabbcc 0.08 0.1
aaBbCc 0.08 0.1
aaBbcc 0.02 0
aabbCc 0.08 0.1
aabbcc 0.32 0.3

The above frequencies assume that double crossovers consist of only 2-strand double crossovers that result in no recombinant progeny. In the absence of double crossovers,
rAC = 0.1 + 0.1 + 0.1 + 0.1 = 0.4
                    1.0

When double crossovers are considered, then the observed
rAB = 0.08 + 0.08 + 0.08 + 0.08 = 0.32
                      1.0

However, the actual r must include 2-strand double crossover events that fail to show observed recombination.

rAC = 0.08 + 0.08 + 0.08 + 0.08 +2(0.02+0.02) = 0.40
                              1.0

Copyright 2000©, Ted Helms

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