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Targeting Histone Deacetylases for Cancer Treatment and Prevention

We have recently identified an APC mutation-mediated mechanism conferring resistance to HDAC inhibitors. Using both in vitro studies and mouse models, we work on developing novel strategies to overcome cancer resistance and enhance the efficacy of HDAC inhibitors in both treatment and prevention of colon cancer.

 

Novel Mechanisms Regulating Chemoresponse and Metastasis

Using tools of molecular and cell biology, we study how cancer cells develop drug resistance and metastatic capability as they progress from benign state to malignant cancers. Currently, we focus on the mechanism of action of novel tumor suppressor genes and tumor-suppressing microRNAs.

 

                                                      

 

                                                               

                                                                                                                                                       

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E-Mail:Bin.Guo@ndsu.edu
Bin Guo, Ph.D.
Department of Pharmaceutical Sciences
College of Pharmacy
North Dakota State University, Fargo, ND 58105
Phone: 701-231-5164