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Targeting Histone Deacetylases for Cancer Treatment and Prevention
We have recently identified an APC mutation-mediated mechanism conferring resistance to HDAC inhibitors. Using both in vitro studies and mouse models, we work on developing novel strategies to overcome cancer resistance and enhance the efficacy of HDAC inhibitors in both treatment and prevention of colon cancer.
Novel Mechanisms Regulating Chemoresponse and Metastasis
Using tools of molecular and cell biology, we study how cancer cells develop drug resistance and metastatic capability as they progress from benign state to malignant cancers. Currently, we focus on the mechanism of action of novel tumor suppressor genes and tumor-suppressing microRNAs.
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