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Targeting the Epigenetic Mechanisms for Cancer Treatment and Prevention
We study how chemotherapeutic and chemopreventive agents induce cell cycle arrest and apoptosis by targeting the epigenetic mechanisms in cancer cells. Using both in vitro studies and mouse models, we work on developing novel strategies to overcome drug resistance and enhance the therapeutic efficacy in both treatment and prevention of cancer.
Novel Mechanisms Regulating Chemoresponse and Metastasis
Using tools of molecular and cell biology, we study how cancer cells develop drug resistance and metastatic capability as they progress from benign state to malignant cancer. Currently, we focus on the mechanism of action of novel tumor suppressor genes and tumor-suppressing microRNAs.
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