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Novel Mechanisms Regulating Cancer Progression
Using tools of molecular and cell biology, we study how cancer cells develop apoptosis resistance and metastatic capability as they progress from benign state to malignant cancer. Our research focuses on the epigenetic action and regulation of tumor-suppressing microRNAs. Combining basic research and translational studies, we try to understand the role of miR-205 and miR-31 in human prostate cancer and to develop new therapeutics to overcome drug resistance.
Targeting Histone Modifications for Cancer Therapy
We study how new therapeutic agents induce cell cycle arrest and apoptosis by targeting histone modifications (acetylation and methylation) in cancer cells. Using both in vitro studies and mouse models, we work on developing novel strategies to enhance therapeutic efficacy in the treatment of cancer.
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