Estelle Leclerc

Assistant Professor
Sudro 17

Phone:

Office: (701)-231-5187
Lab: (701)-231-5281

Email: Estelle.Leclerc@ndsu.edu

Education

1994 PhD, University Paris XI, France

Positions

1994 - 1998 Post-doctoral Associate, ETH-Zürich, Switzerland

1998 - 2003 Post-doctoral Associate, The Scripps Research Institute, La Jolla, CA

2004 Junior Group Leader, Children's Hospital, Zürich, Switzerland

2005 - 2009 Research Assistant Professor, Florida Atlantic University, Boca Raton, FL

Fall 2009 Assistant Professor of Pharmaceutical Sciences, NDSU, Fargo, ND

Research Interests

The Receptor for Advanced Glycation Endproducts (RAGE) is an immunoglobulin like receptor involved in major human diseases such as cancer, diabetes or Alzheimer's Disease. In several mouse models of human pathologies or diseases, antibodies against RAGE have shown promising results. My laboratory is interested in developing new monoclonal antibodies that can block the interaction of RAGE with its ligands. In the laboratory, we use methods of Molecular Biology, Biochemistry and Cell Biology.

Recent Publications (from 34 publications)

Ostendorp, T., Weibel, M., Leclerc, E., Kleinert, P., Kroneck, P.M.H., Heizmann, C.W. and Fritz, G. (2006), Biochem. Biophys. Res. Comm. 347, 4-11, Expression and purification of the soluble isoform of human receptor for advanced glycation end products (sRAGE) from Pichia pastoris.

Dattilo, B.M., Fritz, G., Leclerc, E., Kooi, C.W., Heizmann, C.W. and Chazin, W.J. (2007), Biochemistry 46, 6957-6970, The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units.

Leclerc, E., Fritz, G., Weibel, M, Heizmann, C.W. and Galichet, A. (2007), J. Biol. Chem. 282, 31317-31331, S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE immunoglobulin domains.

Ostendorp, T., Leclerc, E., Galichet, A., Koch, M., Demling, N., Weigle, B., Heizmann, C.W., Kronek, P.M. and Fritz, G. (2007), EMBO J. 26, 3868-78, Structural and functional insights into RAGE activation by multimeric S100B.

Buetler, T.M., Leclerc, E., Baumeyer, A., Latado, H., Newell, J., Adolfsson, O., Parisod, V., Richoz, J., Maurer, S., Foata, F., Piguet, D., Junod, S., Heizmann, C.W. and Delatour, T. (2008), Molecular Nutrition and Food Research 52, 370-378. N-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response.

Sturchler, E., Galichet, A., Weibel, M., Leclerc, E. and Heizmann, C.W. (2008), J. of Neuroscience. 28(20):5149-5158. Site Specific Blockade of RAGE-Vd prevents amyloid-beta oligomers neurotoxicity.

Leclerc, E., Fritz, G., Vetter, S. and Heizmann, C.W. (2008), B.B.A. M.C.R., 1793:993-1007 Interaction of S100 proteins with RAGE: an update.

Leclerc, E., Sturchler, E. and Heizmann, C.W. Book chapter: Calcium Regulation by EF-hand Proteins in the Brain. In Handbook of Neurochemistry and Molecular Biology, Springer-Verlag Eds., Berlin Heidelberg. In press.

Leclerc, E., Sturchler, E., Vetter, SV. and Heizmann, C.W. (2009), Reviews in the Neurosciences, Cross-talk between Calcium, amyloid b and the Receptor for Advanced Glycation Endproducts in Alzheimer's Disease. In press.