Jagdish Singh, Ph.D.

Professor & Chair
102A Sudro Hall
701-231-7943
Jagdish.Singh@ndsu.edu

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Vita

Jagdish Singh
Biography

Jagdish Singh is Professor and Chair of the Department of Pharmaceutical Sciences at NDSU College of Pharmacy, North Dakota and is a Fellow of American Association of Pharmaceutical Scientists (AAPS). Singh's research efforts focus on the mechanistic studies for developing and testing novel delivery technologies to deliver biotechnologically derived molecules (e.g., peptide, protein, and gene). US Department of Defense, National Institutes of Health, PhRMA Foundation, and AFPE have funded his research. Singh has published over 130 peer-reviewed papers and 230 abstracts. Singh received twice NDSU College of Pharmacy Researcher of the Year awards and was recognized with Fred Waldron Research Award in Year 2002 in recognition of his outstanding contribution in research and creative activities at NDSU.

Singh teaches Novel Dosage and Drug Delivery Systems to Pharm.D. and graduate students at NDSU and received thrice the North Dakota State University College of Pharmacy Teacher of the Year awards. He was also recognized twice as a preferred professor by MortarBoard for his continued service and dedication to the students of NDSU through excellence in academic teaching.

Singh has supervised 28 graduate students as their major advisor. He has also supervised two research associates, and has mentored over two dozen undergraduate and professional (Pharm.D.) research students. Singh has also served/ is serving on advisory committee of 25 graduate students in Pharmaceutical Sciences, Chemistry, Polymers and Coatings at NDSU. Singh believes in a good graduate program and derives pleasure in mentoring large number of graduate students, seeing them maturing as scientists and excelling in their employment after graduation. He was instrumental in developing and implementing the combined Pharm.D./Ph.D. program at NDSU College of Pharmacy.

Singh is a member and actively participates in several national and international professional and scientific societies (e.g., American Association of Advancement of Science, American Association of Pharmaceutical Scientists, American Association of Colleges of Pharmacy, and Controlled Release Society, Inc.). Singh is also a member of United States Pharmacopoeia (1995-current) and serves as member of editorial boards of Pharmaceutical Development and Technology; recent patents on Endocrine Metabolic & Immune Drug Discovery; recent patents in Drug Delivery and Formulation; and reviewer of grants and manuscripts for several pharmaceutical and biomedical journals.

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Education

Ph.D.		(1982)		Pharmaceutics		BHU Institute of Technology, Varanasi
Postdoctoral Fellowship		(1985-1988)		Pharmaceutics		University of Otago, Dunedin
Postdoctoral Fellowship		(1992-1994)		Pharmaceutics		University of California, San Francisco

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Professional Experience

2002-present		Chair, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND
2001-present		Professor, Pharmaceutical Sciences, North Dakota State University, Fargo, ND
1999 - 2001		Associate Professor, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND
1994 - 1998		Assistant Professor, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND
1990-1992		Associate Professor (Reader), Department of Pharmaceutics, BHU Institute of Technology, Varanasi
1979 - 1989		Assistant/Sr. Assistant Professor (Lecturer/Sr. Lecturer), BHU Institute of Technology, Varanasi

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Awards

2004:		Fellow, AAPS (American Association of Pharmaceutical Scientists)
2001-2002		Waldron Research Award in recognition of outstanding research achievement at North Dakota State University
2001-2002		Teacher of the Year Award, College of Pharmacy, North Dakota State University
2000-2001		Researcher of the Year Award, College of Pharmacy, North Dakota State University
1999-2000		Teacher of the Year Award, College of Pharmacy, North Dakota State University
1998-1999		Researcher of the Year Award, College of Pharmacy, North Dakota State University
1998-1999		Preferred Professor by Mortar Board
1997-1998		Teacher of the Year Award, College of Pharmacy, North Dakota State University
1997-1998		Preferred Professor by Mortar Board
1992-1994		Visiting Postdoctoral Fellowship, University of California, San Francisco, CA
1977-1979		University Grants Committee Postdoctoral Fellowship, New Zealand
1977-1979		UGC Fellowship, Government of India
1973-1977		UGC Scholarship, Government of India

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Professional Membership

2006 - current		Member, Editorial Board of recent Patents on Drug Delivery and Formulation
2006 - current		Member, Editorial Board of recent Patents on Endocrine Metabolic & Immune Drug Discovery
2006 - current		Member, Editorial Board of Pharmaceutical Development and Technology
1995 - current		Member, US Pharmacopeia
		Member, Golden Key
		Member, Rho Chi (National Pharmacy Honor Society)
1994 - current		Member, American Association for the Advancement of Science
1994 - current		Member, American Association of Colleges of Pharmacy
1993 - current		Member, American Association of Pharmaceutical Scientists
1993 - current		Member, Controlled Release Society, Inc.
		Member, Association of Pharmaceutical Teachers of India
1986 - 1988		Member, Otago Pharmacological Association, Inc.
1986 - 1988		Member, Otago Medical School Research Council

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Research

Jagdish Singh
Research

In recent years great progress has been made in pharmacotherapy, and many important new drugs have been introduced to clinical medicine. Even greater progress has been achieved in the biopharmaceutical technology, which has made the precise control of drug delivery to the body by different routes, using a variety of sophisticated delivery systems. However, the delivery of proteins and peptides is somewhat of a "black box." The development of a whole new generation of potent therapeutic agents based on biotechnology and genetic engineering has brought the limitations of conventional drug delivery into sharp focus and is forcing a fundamental reappraisal of the basic mechanisms of drug absorption and transport. Many of these exciting new compounds are unstable polar macromolecules with very short biological half-lives whose clinical application is prevented by problems with delivery. If methods can be devised to overcome the natural barriers to their absorption, transport and uptake, these agents promise to revolutionize drug therapy and bring enormous benefits to medicine and mankind. Therefore, my research efforts are directed towards the mechanistic studies for developing and testing novel delivery technologies to deliver biotechnologically derived molecules (e.g., peptide, protein, and plasmid DNA).

The specific research interests are: transdermal delivery of bioactive materials including proteins and peptides using physical (iontophoresis, electroporation and ultrasound) and chemical penetration enhancers; understand the mechanisms of transdermal transport enhancement, using FT-IR, DSC, Atomic Force Microscopy, and Electron Microscopy; skin bioengineering and skin irritations; development of suitable animal model for humans for risk assessment from percutaneous absorption of pesticides and other environmental contaminants. Other research interests are drug targeting to lungs using drug loaded biodegradable microspheres, conformational and chemical stabilization of proteins in delivery systems, microencapsulation of biomaterials including proteins, plasmid DNA, and use of smart polymers for delivery of peptides and proteins.

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Publications

Jagdish Singh
Selected Publications (From a list of 120 publications):

1. Babu Medi and Jagdish Singh, Skin targeted DNA vaccine delivery using electroporation in rabbits. II. Safety. International Journal of Pharmaceutics, 308 (1-2), 61-68, 2006.

2. S Chen, R. Pieper, DC Webster and J Singh, Triblock copolymers: Synthesis, characterization, and delivery of a model protein. International Journal of Pharmaceutics, 288 (2), 207-218, 2005.

3. Medi and Jagdish Singh, In Vivo Non-Viral Cutaneous Gene Delivery using Electroporation. International Journal of Pharmaceutics, 294, 53-63, 2005.

4. Somnath Singh and Jagdish Singh, Controlled Release, conformational stability, and biological activity of lysozyme from phase sensitive smart polymer based delivery systems. International Journal of Pharmaceutics, 271, 189-196, 2004.

5. Babu Medi and Jagdish Singh, Electronically facilitated transdermal delivery of human parathyroid hormone (1-34). International Journal of Pharmaceutics, 263, 25-33, 2003.

6. Sumeet K Rastogi and Jagdish Singh, Transepidermal transport enhancement of insulin by lipid extraction and iontophoresis. Pharmaceutical Research,19, 427-433, 2002.

7. Feirong Kang, Ge Jiang, Ann Hinderliter, Patrick P DeLuca, and Jagdish Singh, Stability of a model protein, lysozyme, during emulsification for preparation of lysozyme-loaded PLGA microspheres. Pharmaceutical Research,19, 629-633, 2002.

8. Matthew J Schaefer and Jagdish Singh, Effect of tricaprin on the physical characteristics and in vitro release of etoposide from PLGA microspheres. Biomaterials, 23, 3465-3471, 2002.

9. J. Singh, M. Gross, B. Sage, H.T. Davis and H. I. Maibach, Regional variation in skin function and cutaneous irritation due to iontophoresis in human subjects. Food and Chemical toxicology, 39 (11), 1079-1086, 2001.

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Teaching

Jagdish Singh
Teaching

Undergraduate Courses

I am responsible for Pharm. Sci. 369 (Pharmaceutics II) and a small portion of the calculations for Pharm. Sci 368 (Pharmaceutics I). Pharmaceutics II emphasizes scientific and professional judgement regarding the usage of drug delivery systems and devices. This course deals with the formulation of topical, rectal, vaginal, prolonged release, inhalation, and injectable dosage and delivery systems and anticipates the role of drug absorption from such systems.

I teach Pharmaceutics II through lecturing, actively involving students in problem solving, and by encouraging reading and completion of problem assignments. I test the students through multiple choice questions, short answer and essay exams. In summary, I think the ability to effectively communicate and to skillfully use basic physico-chemical principles in the formulation, dispensing and handling of dosage and delivery systems is crucial for the success of our graduates. I will continue to implement and evaluate methods designed to engage students in active learning and problem solving.

Graduate Courses

I developed and introduced a pharmaceutics and drug delivery graduate course (Pharm. Sci. 796) in the spring of 1996. This course deals with principles involved in the transport of drugs through biologic membranes, dermatotoxicity, colloids and their application in drug delivery systems, controlled release oral products, chemical kinetics and its application in stability of pharmaceutical dosage and delivery systems. I will be offering this course on an alternate year schedule.

I also offer my graduate students an individual study course, advanced pharmaceutics (Pharm. Sci. 793), to strengthen their understanding about the techniques and research topics they are pursuing in my laboratory. For example, I emphasize Fourier transform infrared spectroscopy, differential scanning calorimetry, high performance liquid chromatography, radioimmunoassays, and topics related to their research including discussions on current publications in their research areas.

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