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Steven (Yue) Qian, Ph.D.

Associate Professor
208 Sudro Hall 
Office Phone: 701.231.8511
Lab Phone: 701.231.8517 
Fax: 701.231.8333 
Steven.Qian@ndsu.edu


Education

1999-2004   Post-doctoral in Free Radical Biology and Medicine, Lab. 
                    Pharmacology and Chemistry National Institute of Environmental 
                    Health Sciences (NIEHS/NIH), Research Triangle Park, NC.
1994-1999   Ph.D. in Free Radical/Radiation Biology, College of Medicine, 
                    The University of Iowa, Iowa City, IA. 

Grants and Fellowships

2012-date   Co-PI, (PI: Paul Schwarz) USDA-USWBSI
                   "Malting Barley Deoxynivalenol Diagnostic Services"

2012-date   PI, USDA-USWBSI
                   "The Occurrence and Frequency, Stability, and Metabolism of 
                   Doxynivalenol-3-Glucoside"

2009-date   PI, National Cancer Institute, NCI (R15CA140833) "Refinement 
                    of  LC/ESR/MS for Studying Lipid Free Radicals in Colon 
                    Cancer Growth”
2008-date    Pilot Project P.I. NDSU, COBRE and NCRR, NIH (P20 RR015566)
                    “New strategies for targeting protease in disease”
2008-2009    P.I. NDSU, INBRE
                    “Identification of Lipid-Derived Radicals Involved in Liver 
                     Proteasome Dysfunction in Ethanol-Fed Rats”
2006-2010   P.I., National Cancer Institute, NIEHS (K22ES-012978)
                   “Endogenous Radicals, Hepatic Lipid peroxidation, and ALD” 
2005-2007   P.I., ND EPScoR and NDSU/College of Pharmacy start-up fund
1999-2004   IRTA Research Fellowship, NIEHS.

Professional Experience

2012-date:    Tenured Associate Professor, Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND.

2012-date:    Guest Researcher/Special Volunteer, Lab. Pharmacology and Chemistry, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC NIEHS, NIH.

2006-date:    Joint Faculty and Assistant Professor, Cellular and Molecular Biology Program (CMB), North Dakota State University, Fargo, ND.

2008-date:   Joint Faculty Member, Investigator, and Assistant Professor, Center for Protease Research, North Dakota State University, Fargo, ND.

2005-2012:   Assistant Professor, Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND.

2004-2007:   Guest Researcher/Special Volunteer, Lab. Pharmacology and Chemistry, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC NIEHS, NIH

2004-2005:   Research Assistant Professor, Division of Drug Delivery and Disposition, School of Pharmacy, The University of North Carolina at Chapel Hill, NC.

1999-2004:   IRTA/Visiting Fellow, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.

1994-1999:   Graduate Research Assistant, Free Radical and Radiation Biology Program, College of Medicine, The University of Iowa, Iowa City, IA.


Research Interests 

  • Free radical chemistry and biology as the related to problems in human health   
  • Iron and oxygen chemistry as the initiation of free radical biological reaction 
  • Oxidative stress and toxicology/xenobiotic disposition leading to pathogenesis in disease processes, such as ALD, DILI, neurological, cardiovascular diseases, and cancer.
  • COX- and LOX-catalyzed lipid (PUFAs) peroxidation, as the related to cancer and other human health problems


Teaching 

2007-2013   Pharmacodynamics (PSCI 411/611), College of Pharmacy, 
                    NDSU, Fargo ND
2009-2012   Pharmacokinetics (PSCI 470/670), College of Pharmacy, 
                    NDSU, Fargo ND
2010-2012   Cancer Cell Biology (PSCI 796), College of Pharmacy, 
                    NDSU, Fargo ND
2010-2011   Individual Study (PSCI 494), College of Pharmacy, 
                    NDSU, Fargo ND
1996-1998  TAs of Free Radical Bio. Med. (77:222), College of Medicine, UI,
                    Iowa City, IA


Professional Honors

2013    Dean’s Award for Excellence in Service, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University
2013    SFRBM Recruitment Committee
2012    Dean’s Award for Excellence in Research, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University
2012    Invited Reviewer, NCI Research Grand Study Section, NIH
2012   NDSU Provost Travel and Research Fund
2011    SFRBM Junior Award Committee
2011    Young Investigator Award Committee, 18th SFRBM
2010   Invited Research Grant Reviewer, Florida Department of Health, James/Esther King Biomedical Research Program and Bankhead-Coley Cancer Research Program
2010    Young Investigator Award Committee of 17th SFRBM
2009   NDSU Professional Development Grant
2009   Young Investigator Award Committee, 16th SFRBM
2008   Outstanding Mentor Certificate, NDSU 2008 Summer Undergraduate Research STEM Program 
2008   NDSU Professional Development Grant
2008    Young Investigator Award Committee, 15th SFRBM
2007   NDSU Professional Development Grant
2007    Young Investigator Award Committee, 14th SFRBM
2006    Young Investigator Award Committee, 13th SFRBM
2006   NDSU Professional Development Grant
2006   Section Chair, 13th Annual Meeting of SFRBM
2004   NIEHS nominee for Burroughs Wellcome Fund 
2003   Research Excellence Award (FARE), National Institutes of Health
2002   Young Investigator Award, International Symposium of EPR Spin Trapping
2001   Young Investigator Award, Free Radical Biology & Medicine (Oxygen) Society
1998   Travel Award, American Society for Photobiology
1997   Travel Awards, University of Iowa 
1997   Travel Award, American Society for Photobiology
1996   Young Investigator Awards, Free Radical Biology & Medicine (Oxygen) Society
1996   Travel Awards, University of Iowa 
1996   Travel Award, Radiation Research Society 

Awards for Students and Advisees:

2008 Best Research Presentation Award - Oluseyi Amele (Summer Intern Undergraduate Student), NDSU 2008 Summer Undergraduate Research STEM Program.

2009 PRACS Institute/James D. Carlson Graduate Student Research Scholarship - Preeti Purwaha (Ph.D. Student from 2007-2011), College of Pharmacy, Nursing, and Allied Sciences, NDSU

2011 PRACS Institute/James D. Carlson Pharmacy Student Research Scholarship - Jingyang Xiao (Pharm. D. student, conducted research in the lab from 2010-2011), College of Pharmacy, Nursing, and Allied Sciences, NDSU.

2013 The 1st Place Oral Presentation Award - Shechinah Tinsley (Summer Intern Undergraduate Student), NDSU 2013 Summer Undergraduate Research STEM Program.

Professional Associations

2006-date: American Association for Cancer Research (AACR) 
2005-date: American Association of Colleges of Pharmacy (AACP)
1996-date: Society for Free Radical Biology & Medicine (SFRBM)

Publications

Malik R, Wagh A, Qian S, Law B. A single-layer peptide nanofiber for enhancing the cytotoxicity of trastuzumab (anti-HER). J. Nanoparticle Research. 15: 1682-1699, 2013. 

Pender-Cudlip MC, Krag KJ, Martini D, Yu J, Guidi A, Skinner SS, Zhang Y, Qu X, He C, Xu Y, Qian SY, Kang JX. Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue. Cancer Sci. 104: 760-764; 2013. 

Wagh, A., Jyoti, R., Mallik, S., Qian, S., Leclerc, E., and Law, B. Polymeric Nanoparticles with Sequential and Multiple FRET Cascade Mechanisms for Multicolor and Multiplexed Imaging, Small. 9: 2129-2139; 2013. 

Gu Y, Xu Y, Law B, and Qian SY. The First Characterization of Free Radicals Formed From Cellular COX-Catalyzed Peroxidation, Free Radic Biol Med. 57: 49-60; 2013. 

Wagh A, Singh J, Qian S, Law B. A short circulating peptide nanofiber as a carrier for tumoral delivery. Nanomedicine: Nanotechnology, Biology, and Medicine. 2012, In press. 

Wagh A, Qian SY, Law B. Development of biocompatible polymeric nanoparticles for in vivo NIR and FRET imaging. Bioconjugate Chem. In press; 2012.

Qian SY, Xu Y, Gu Y. Combination of Spin-Trapping, LC/ESR and LC/MS Technique in Characterization of PUFA-Derived Free Radials in Lipid Peroxidation. Acta Biophysica Sinica, 28: 355-372; 2012

Senay Simsek, Kimberly Burgess, Kristin L. Whitney, Yan Gu, Steven Y. Qian. Analysis of Deoxynivalenol and Deoxynivalenol-3-glucoside in Wheat. Food Control. In press, 2012.

Purwaha P, Gu Y, Kelavkar U, Kang JX, Law B, Wu E, Qian SY. LC/ESR/MS study of pH-dependent radical generation from 15-LOX catalyzed DPA peroxidation. Free Radic Biol Med. 51: 1461-1470; 2011. 

Malik R, Qian SY, Law B. Design and synthesis of a near-infrared fluorescent nanofiber precursor for detecting of cell-secreted urokinase activity. Analytical Biochem. 412: 26-33; 2011. 

Nyren-Erickson EK, Haldar MK, Gu Y, Qian SY, Friesner DL, Mallik S. Fluorescent liposomes for differential interactions with glycosaminoglycans. Anal. Chem. 83: 5989-5995; 2011. 

Wang F, Bhat K, Doucette M, Zhou S, Gu Y, Law B, Liu X, Wong ET, Kang JX, Hsieh TC, Qian SY, Wu E. Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. Curr. Mol. Med. 11:1-9; 2011. 

Zhang W, Phillips K, Wielgus AR, Liu J, Albertini A, Zucca FA, Faust R, Qian SY, Miller DS, Chignell CF, Wilson B, Jackson-Lewis V, Przedborski S, Joset D, Loike J, Hong JS, Sulzer D, Zecca L. Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease. Neurotox Res. 19: 62-72; 2011. 

Zou Y, Chang S, Gu Y, Qian SY. Antioxidant activity and phenolic compositions of the extract of lentils (Lens culinaris var. Morton) and its fractions. J. Agr Food Chem. 59: 2268-2276; 2011. 

Xiao Y, Gu Y, Purwaha P, Ni K, Law B, Mallik S, Qian SY. Characterization of free radicals formed from COX-catalyzed DGLA peroxidation. Free Radic Biol Med. 50: 1163-1170; 2011. 

Berg AK, Yu Q, Haldar MK, Qian SY, Srivastava DK. Solvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase. B.B.A. 1804: 704-713; 2010. 

Subramaniam R, Xiao Y, Li Y, Qian SY, Sun W, Mallik S. Light-mediated and H-bond facilitated liposomal release: The role of lipid head groups in release efficiency. Tetrahedron Letters, 51: 529-532; 2010. 

Zhang Q, Yao F, O’Rourke S, Qian SY, Sun C. Angiotensin II enhances GABAB receptor-mediated responses and expression in nucleus tractus solitarii of rats. Am J Physiol Heart Circ Physiol. 297: H1837-H1844; 2009. 

Yu Q, Xiao Y, Ni K, Qian SY.  Identification and characterization of carbon-centered free radicals formed from lipoxygenase-catalyzed lipid peroxidation of DLA. Chinese J. Analytical Chem.  37:1815-1819, 2009.

Yu Q, Purwaha P, Ni K, Sun C, Mallik S, and Qian SY. Characterization of Novel Radicals from COX-Catalyzed Arachidonic Acid Peroxidation. Free Radic Biol Med., 47: 568-576. 2009.

Syn WK, Yang L, Chiang DJ, Qian Y, Jung Y, Karaca1 G, Choi SS, Witek RP, Omenetti A, Pereira TA, Diehl AM. Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. Liver Int. 29: 1262-1272; 2009. 

Shan Z, Yu Q, Guo B, and Qian SY.  A combination study of spin-trapping, LC/ESR and LC/MS on carbon-centred radicals formed from lipoxygenase-catalysed peroxidation of eicosapentaenoic acid. Free Radical Research. 43: 1-15; 2009. DOI: http://dx.doi.org/10.1080/10715760802567606, PMID: 19085251.

Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M, and Hong JS. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem Res. 33: 2044-2053; 2008.  DOI: http://dx.doi.org/10.1007/s11064-008-9675-z, PMID: 18368483.

Liu J, Qian SY, Guo Q, Jiang J, Waalkes MP, Mason RP, and Kadiiska MB.  Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studies. Free Radic Biol Med. 45: 475-481; 2008. PMID: 18501199, DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2008.04.041.

Yu Q, Shan Z, Ni K, and Qian SY. LC/ESR/MS Study of Spin Trapped Carbon-Centered Radicals Formed From In Vitro Lipoxygenase-Catalyzed Peroxidation of -Linolenic Acid.  Free Radical Research. 42: 442-455; 2008. DOI: http://dx.doi.org/10.1080/10715760802085344. PMID: 18484409;

Yang Z, Yang S, Hong JS, Qian SY, Kadiiska MB, Tennant RW, Waalkes MP, and Liu J. Cadmium-induced toxicity in rat primary mid-brain neuro-glia cultures: role of oxidative stress from microglia.  Toxicol. Sci.  98: 488-494; 2007. PMID: 17483498, DOI: http://dx.doi.org/10.1093/toxsci/kfm106.

Shan X, Chi L, Ke Y, Luo C, Qian S, Gozal D, Liu R. Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage. Neurobiol Dis. 28: 206-215; 2007. PMID: 17719231,  DOI: http://dx.doi.org/10.1016/j.nbd.2007.07.013.

Dyers JD, Que (Qian, misspell) SY, VanDerveer D, and Bu XR. Synthesis and structures of new salen complexes with bulky groups. Inorg. Chim. Acta.  359: 197-203; 2006. 

Qian SY, Kadiiska MB, Guo Q, Liu J, and Mason RP.  A novel protocol to identify and quantify all spin trapped free radicals from in vitro/in vivo interaction of HO• and DMSO: LC/ESR, LC/MS, and dual spin-trapping combinations.  Free Radic. Biol. Med. 38: 125-135; 2005. PMID: 15589381, DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2004.09.024.

Guo Q, Gao G, Qian SY, and Mason RP. Novel identification of a sulfur-centered radical-derived DMPO nitrone adduct formed from the oxidation of dithiothreitol by LC/ELISA, LC/ESI-MS and LC/MS/MS.  Chem. Res. Toxicol.  17: 1481-1490; 2004. PMID: 15540946, DOI: http://dx.doi.org/10.1021/tx049837o.

Colon ML, Qian SY, Vanderveer D, and Bu XR.  Chiral bimetallic complexes from chiral salen metal complexes and mercury (II) halides and acetates.  Inorg. Chim. Acta. 357: 83-88; 2004.

Towner RA, Qian SY, Kadiiska MB, and Mason RP.  In vivo identification of aflatoxin-induced free radical in rat bile.  Free Radic. Biol. Med.  35: 1330-1340; 2003. PMID: 14607532,  DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2003.08.002.

Qian SY, Guo Q, Mason RP.  Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of ω-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and Tandem MS. Free Radic. Biol. Med. 35: 33-44; 2003. PMID: 12826254, DOI: http://dx.doi.org/10.1016/S0891-5849(03)00217-X.

Guo Q, Qian SY, and Mason RP.  Separation and identification of DMPO adducts of oxygen-centered radicals formed from organic hydroperoxides by HPLC-ESR, ESI-MS and MS/MS. J. Am. Soc. Mass Spectr.  14: 862-871; 2003. DOI: http://dx.doi.org/10.1016/S1044-0305(03)00336-2, PMID: 12892910.

Qian SY, Yue GH, Tomer KB, and Mason RP.  Identification of all classes of spin-trapped carbon-centered radicals in soybean lipoxygenase-dependent lipid peroxidations of ω-6 PURA via LC/ESR, LC/MS and MS/MS.  Free Radic. Biol. Med.  34: 1017-1028; 2003. PMID: 12684086, DOI: http://dx.doi.org/10.1016/S0891-5849(03)00031-5.

Qian SY, Tomer KB, Yue GH, Guo Q, Kadiiska MB, and Mason RP.  Characterization of the initial carbon-centered pentadienyl radical and subsequent radicals in lipid peroxidation: Identification via LC/ESR and MS.  Free Radic. Biol. Med.  33: 998-1009; 2002. PMID: 12361809, DOI: http://dx.doi.org/10.1016/S0891-5849(02)00992-9.

Guo Q, Corbett JT, Yue GH, Fann YC, Qian SY, Tomer KB, and Mason RP.  Electron spin resonance investigation of semiquinone radicals formed from the reaction of ubiquinone 0 with human oxyhemoglobin.  J. Biol. Chem.  277: 6104-6110; 2002. PMID: 11748217, DOI: http://dx.doi.org/10.1074/jbc.M106395200.

Qian SY, Chen YR, Deterding LJ, Fann YC, Chignell CF, Tomer KB, and Mason RP.  Identification of protein-derived tyrosyl radical in the reaction of cytochrome c and hydrogen peroxide: characterization by ESR spin-trapping, HPLC and MS. Biochem. J. 363: 281-288; 2002. PMID: 11931655.

Liang S, Derveer DV, Qian SY, Sturgeon B, and Bu XR.  A chiral salen vanadyl complex with two significantly different configurations in solid state: synthesis, characterization, and molecular structure.  Polyhedron.  21: 2021-2025; 2002. 

Wang HP, Qian SY, Schafer FQ, Domann FE, Oberley LW, and Buettner GR.  Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy.  Free Radic. Biol. Med.  30: 825-835; 2001. PMID: 11295525,  DOI: http://dx.doi.org/10.1016/S0891-5849(01)00469-5.

Qian SY, Wang HP, Schafer FQ, and Buettner GR.  EPR detection of lipid-derived free radicals from PUFAs, LDL, and cell oxidations.  Free Radic. Biol. Med.  29: 568-579; 2000. PMID: 11025200, DIO: http://dx.doi.org/10.1016/S0891-5849(00)00407-X.

Schafer FQ, Qian SY.; and Buettner GR. Iron and free radical oxidations in cell membranes. cell. Mol. Biol.  46: 657-662; 2000. PMID: 10872752.

Qian SY, and Buettner GR.  Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations.  Free Radic. Biol. Med.  26: 1447-1456; 1999. PMID: 10401608,  DOI:  http://dx.doi.org/10.1016/S0891-5849(99)00002-7.

Liu NF, Chen RX, Zhang LR, and Qian, Y.  Detection of hydroxyl radicals in the oxidation of LDL by ESR spin trapping technique.  Chinese J. Pathophysiology. 10: 631-634; 1994. 

Yan H, Chen HL, Qian Y, and Tang WX.  The first study on 2’,5’-dideoxynucleosidyl radicals formed from the anaerobic photolysis of 2’,5’-dideoxynucleosidylcobalamines by the ESR spin-trapping technique.  J. Inorg. Biochem. 56: 265-271; 1994.

Xu H, Xu Z, Li MX, Li BL, Qian Y, You XZ, Zhu DL, and Yu YP.  Study on basicity of axial ligands effects on monomeric dioxygen adduct of cobalt(II)-schiff base complex by ESR method.  J. Inorg. Chem.  9: 331-335; 1993. 

Xu JH, He JP, and Qian Y.  Photoinduced coupling reaction of benzotriazole with aromatic hydrocarbons sensitized by 9, 10-dicyanoanthracene (DCA) via an electron-transfer mechanism.  J. Chem. Soc., Chem. Comm. 10: 714-715; 1991. 

Fen R, Qian Y, Xu JY, Wang SW, Li HM, and Shi Q.  Therapeutic ultrasound cavitation and its free radical ESR determination.  Acta Acustica.  16: 306-312; 1991. 

Chen HL, Qian Y, Chen GJ, and Tang WX.  Study of coenzyme B12 model compounds: identification of alkyl radicals in RCo(Salen)L solution by spin trapping-ESR techniques.  Chinese Science Bulletin.  36: 42-46; 1991. 

Fen R, Qian Y, Xu JY, Shi Q, Wang SW, and Li HM.  Therapeutic ultrasound cavitation and its free radical ESR determination.  Chinese J. Acoustics.  10: 131-138; 1991. 

Chen HL, Qian Y, Chen GJ, and Tang WX.  Study of coenzyme B12 model compounds: EPR identification of alkyl radicals in RCo(Salen)L solution.  Chinese Science Bulletin. 14: 1070-1073; 1990.

Shi Q, Qian Y, Fen R, Liu H, Xu JY, and Li HM.  Spectrofluorimetry study of free radicals produced by simulated therapeutic ultrasound.  Acta Biophysica Sinica.  6: 485-489; 1990. 

Sun SH, Meng QJ, You XZ, Qian Y, and Bu XR.  Electrochemistry of RCo3(CO)9 and ESR Spectra of RCo3(CO)9•-.  Chinese J. Magnetic Resonance.  6: 137-142; 1989. 

Gan LR, Wu YY, Li H, Hu YF, and Qian Y.  Study on some bis-schiff bases from isophthalic aldehyde and their copper (II) complexes.  J. Inorg. Chem.  5: 81-89; 1989. 

Meng QJ, Bu XR, Sun SH, Qian Y, and You XZ.  ESR studies on iminato-VO(II) complexes.  J. Inorg. Chem.  5: 40-45; 1989. 

Yang SY, Ye F, Qian Y, Gao JY, and Liu YC.  ESR studies of -tocopherol model-chromanoxyl radical.  Acta Biophysica Sinica.  5: 349-353; 1989. 

Qian Y.  Sonochemistry: historical development and modern aspects (Translated Review).  J. Jian Teachers College.  6: 75-88; 1988. 

Li HM, Qian Y, Tang JH, and Fen R.  Preliminary research on cavitation on medical ultrasound.  J. Jian Teachers College. 5: 1-4; 1988. 

 

 


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North Dakota State University
Phone: +1 (701) 231-7661 / Fax: (701) 231-8333
Campus address: Sudro Hall 116
Physical/delivery address: 1401 Albrecht Blvd, Fargo, ND 58102
Mailing address: NDSU Dept. 2665 / PO Box 6050 / Fargo, ND 58108-6050
Page manager: Pharmaceutical Sciences
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Last Updated: Wednesday, February 19, 2014 4:13:32 PM