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Sylvio May, Associate Professor

Ph.D., Physics, Friedrich-Schiller University , Jena, Germany (1996), Thesis: Elastic properties of mixed and charged amphiphilic membranes

Department of Physics,
North Dakota State University, Dept # 2755,
Fargo ND, 58108-6050, USA
Office: South Engineering 220A
Tel: (701) 231-7048 or 231-8974
Fax: (701) 231-7088
email: sylvio (dot) may (at) ndsu (dot) edu

Research Interests

  • Thermodynamics of lipid membranes and interactions with biopolymers
  • Electrostatics, Poisson-Boltzmann theory, ionic interactions in soft matter systems
  • Modeling the kinetics of liposomal drug delivery

List of Publications

80. Daniel Harries, Sylvio May, and Avinoam Ben-Shaul, "Counterion Release in Membrane--Biopolymer Interactions", Soft Matter, in press (2013)

79. Muyang Wang, Er-Qiang Chen, Shuang Yang, and Sylvio May, "Incorporating Headgroup Structure into the Poisson-Boltzmann Model of Charged Lipid Membranes", J. Chem. Phys. 139, 024703 (2013)

78. Miha Fosnaric, Ales Iglic, Daniel M. Kroll, and Sylvio May, "Monte Carlo simulations of a polymer confined within a fluid vesicle", Soft Matter, 9, 3976 (2013)

77. Stephan Loew, Edgar E Kooijman, and Sylvio May, "Increased pH-sensitivity of protein binding to lipid membranes through the electrostatic-hydrogen bond switch", Chem. Phys. Lipids, 169, 9-18 (2013)

76. Christiane Decker, Harald Schubert, Sylvio May, and Alfred Fahr, "Pharmacokinetics of temoporfin-loaded liposome formulations: Correlation of liposome and temoporfin blood concentration", Journal of Controlled Release, 166, 277-285 (2013)

75. Sylvio May and Klemen Bohinc, "Mean-field electrostatics of stiff rod-like ions", Proceedings of the CECAM Workshop ``New challenges in Electrostatics of Soft and Disordered Matter'', D.S. Dean, J. Dobnikar, A. Naji and R. Podgornik editors. Pan Stanford, 13 pages, in press (2013)

74. Sylvio May and Alfred Fahr, ''Self-assembled delivery vehicles for poorly water-soluble drugs: Basic theoretical considerations and modeling concepts'', Drug Delivery Strategies for Poorly Water-Soluble Drugs. D.Douroumis and A.Fahr editors. Wiley, Chapter 1, 1-35 (2013)

73. Ahis Shrestha, Klemen Bohinc, and Sylvio May, ''The Immersion Depth of Positively versus Negatively Charged Nanoparticles at the Air-Water Interface: A Poisson-Boltzmann Model'', Langmuir, 28 (40), 14301-7 (2012)

72. Klemen Bohinc, Gerald Brezesinski, and Sylvio May, "Modeling the influence of adsorbed DNA on the lateral pressure and tilt transition of a zwitterionic lipid monolayer'', Phys. Chem. Chem. Phys., 14, 10613-10621 (2012)

71. Christiane Decker, Alfred Fahr, Judith Kuntsche, and Sylvio May, "Selective Partitioning of Cholesterol and a Model Drug into Liposomes of Varying Size", Chem. Phys. Lipids, 165, 520-529 (2012)

70. Klemen Bohinc, Ahis Shrestha, Milan Brumen, and Sylvio May, "The Poisson-Helmholtz-Boltzmann model of the electric double layer: analysis of monovalent ionic mixtures", Phys. Rev. E 85, 031130 (2012)

69. Sylvio May, "Mean-field Continuum Electrostatics of Lipid Membranes", in: Encyclopedia of Surface and Colloid Science. P. Somasundaran editor. Taylor and Francis, Chapter 275, 1-15 (2012)

68. Klemen Bohinc, Ahis Shrestha, and Sylvio May, "The Poisson-Helmholtz-Boltzmann Model", Eur. Phys. J. E, 34, 108 (2011)

67. Sylvio May and Klemen Bohinc, "Attraction between like charged surfaces mediated by uniformly charged spherical colloids in a salt solution", Croat. Chem. Acta, 84 (2), 251-257 (2011)

66. Stephan Loew, Alfred Fahr, and Sylvio May, "Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers", Journal of Drug Delivery, 2011, 376548 (2011)

65. Demmelash H Mengistu, Edgar E Kooijman, and Sylvio May, "Ionization Properties of Mixed Lipid Membranes: A Gouy-Chapman Model of the Electrostatic-Hydrogen Bond Switch", BBA Biomembranes,  1808, 1985-1992 (2011)

64. Klemen Bohinc, Jurij Rescic, Stefano Maset, and Sylvio May, "Debye-Hückel theory for mixtures of rigid rod-like ions and salt", J. Chem. Phys, 134, 074111 (2011)

63. Waipot Ngamsaad, Sylvio May, Alexander J. Wagner, and Wannapong Triampo, "Pinning of Domains for Fluid-Fluid Phase Separation in Lipid Bilayers with Asymmetric Dynamics", Soft Matter, 7 (6), 2848 - 2857(2011)

62. Hossam Hefesha, Sylvio May, Stephan Loew and Alfred Fahr, "Transfer Mechanism of Temoporfin between Liposomal Membranes" Journal of Controlled Release, 150, 279-286  (2011)

61. Demmelash H. Mengistu, Klemen Bohinc, and Sylvio May , "A model for the electrostatic contribution to the pH-dependent nonideal mixing of a binary charged-zwitterionic lipid bilayer", Biophys. Chem., 150, 112-118 (2010)

60. Demmelash H. Mengistu, Klemen Bohinc, and Sylvio May , "Poisson-Boltzmann model in a solvent of interacting Langevin dipoles", EPL (88), 14003 (2009)

59. Demmelash H. Mengistu, Klemen Bohinc, and Sylvio May , "Binding of DNA to Zwitterionic Lipid Layers mediated by Divalent Cations", J. Phys. Chem. B., 113 (36), 12277-12282 (2009)

58. Miha Fosnaric, Ales Iglic, Daniel M. Kroll, and Sylvio May, "Monte Carlo simulations of complex formation between a mixed fluid vesicle and a charged colloid", J. Chem. Phys., 131, 105103  (2009)

57. Klemen Bohinc, Ales Iglic, Stefano Maset, and Sylvio May, "The interaction between charged macroions induced by rod-like ions", IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany, Vol. 25/8 Micro- and Nanosystems in Medicine, Active Implants, Biosensors, pp. 329-331 (2009)

56. Sylvio May, "Trans-monolayer coupling of fluid domains in lipid bilayers", Soft Matter, 5, 3148 - 3156 (2009)

55. Stefano Maset, Jurij Rescic, Sylvio May, Janez Ivan Pavlic, and Klemen Bohinc,  "Attraction between like-charged surfaces induced by orientational ordering of divalent rigid rod-like counterions: theory and simulations", J. Phys. A: Math Theor., 42, 105401 (2009)

54. Stephan Loew, Anne Hinderliter, and Sylvio May, "Stability of protein-decorated mixed lipid membranes: the interplay of lipid-lipid, lipid-protein, and protein-protein interactions", J. Chem. Phys. 130 045102 (2009)

53. Sylvio May, ''Models of Membrane Fusion'', Chapter 12 in: Handbook of Molecular Biophysics. H. Bohr editor. Wiley-VCH, pages 385-414 (2009)

52. Shuang Yang and Sylvio May, "Release of cationic polymer-DNA complexes from the endosome: A theoretical investigation of the proton sponge hypothesis", J. Chem. Phys., 129 185105 (2008)

51. Demmelash H. Mengistu and Sylvio May, "Nonlinear Poisson-Boltzmann model of charged lipid membranes: Accounting for the presence of zwitterionic lipids", J. Chem. Phys. 129, 121105 (2008)

50. Demmelash H. Mengistu and Sylvio May, "Debye-Huckel theory of mixed charged-zwitterionic lipid layers", Eur. Phys. J. E, 26, 251-260 (2008)

49. Assaf Zemel, Avinoam Ben-Shaul, and Sylvio May, "Effect of Amphipathic Peptides on the Spontaneous Curvature and Bending Rigidity of Lipid Membranes", J. Phys. Chem. B, 112; 6988-6996 (2008)

48. Sylvio May, Ales Iglic, Jurij Rescic, Stefano Maset and Klemen Bohinc, "Bridging like-charged macroions through long divalent rod-like ions", J. Phys. Chem. B, 112, 1685-1692 (2008)

47. Andrew Haugen and Sylvio May, "The influence of zwitterionic lipids on the electrostatic adsorption of macroions onto mixed lipid membranes", J.Chem.Phys., 127, 215104 (2007)

46. Alexander J Wagner, Stephan Loew, and Sylvio May, "Influence of Monolayer-Monolayer Coupling on the Phase Behavior of a Fluid Lipid Bilayer", Biophys. J., 93, 4268-4277 (2007)

45. Alexander J. Wagner and Sylvio May, "Electrostatic interactions across a charged lipid bilayer", Eur. Biophys. J., 36 (4-5): 293-303, (2007)

44. Sylvio May and Avinoam Ben-Shaul, "Molecular Packing in Cylindrical Micelles", Chapter 2 in: Giant Micelles: Properties and Applications. R. Zana and E. Kaler editors. CRC Press, Boca Raton, p.41-80, (2007)

43. Miha Fosnaric, Ales Igic and Sylvio May, "Influence of rigid inclusions on the bending elasticity of a lipid membrane", Phys. Rev. E, 74 051503 (2006)

42. Klemen Bohinc, Veronica Kralj-Iglic, Tomas Slivnik, Sylvio May and Ales Iglic, "Spatial distribution of divalent rod-like ions in contact with a charged surface", Electrotechnical Review 73 (2-3) pp. 137-142 (2006)

41. Anne Hinderliter and Sylvio May, "Cooperative adsorption of proteins onto lipid membranes", J.Phys. Cond. Matter, 18, S1257-S1270 (2006)

40. Emmanuel C. Mbamala, Alfred Fahr and Sylvio May, "An electrostatic model for mixed cationic-zwitterionic lipid bilayers", Langmuir, 22 (11), 5129 -5136 (2006)

39. Maria Maddalena Sperotto, Sylvio May and Artur Baumgaertner, "Modeling of Proteins in Membranes", Chem. Phys. Lipids, 141, 2-29 (2006)

38. Klemen Bohinc, Darko Lombardo, Veronika Kralj-Iglic, Miha Fosnaric, Sylvio May, Franjo Pernus, Henry Hagerstrand and Ales Igic, "Shape variation of bilayer membrane daughter vesicles induced by anisotropic membrane inclusions", Cell. Mol. Biol. Lett., 11, 90-101 (2006)

37. Veronica Kralj-Iglic, Blaz Babnik, Dorit R. Gauger, Sylvio May and Ales Iglic, "Quadrupolar ordering of phospholipid molecules in narrow necks of phospholipid vesicles", J. Stat. Phys., 125 (3), pp. 723-748 (2006)

36. Miha Fosnaric, Klemen Bohinc, Dorit R. Gauger, Veronika Kralj-Iglic, Ales Igic and Sylvio May, "The influence of anisotropic membrane inclusions on curvature elastic properties of lipid membranes", J. Chem. Inf. Model., 45 (6), 1652 -1661 (2005)

35. Sylvio May, "Stability of macroion-decorated lipid membranes" , Journal of Physics: Condensed Matter, 17, R833-R850 (2005)

34. Alfred Fahr, Peter van Hoogevest, Sylvio May, Nill Bergstrand and Mathew Louis Steven Leigh, "Transfer of lipophilic drugs between liposomal membranes and biological interfaces: Consequences for drug delivery", Eur. J. Pharm. Sci., 26 (3-4), 251-65 (2005)

33. Klemen Bohinc, Ales Iglic and Sylvio May, "Self-assembly of linear aggregates on curved membranes", Europhys. Lett., 71 (1), 145-151 (2005)

32. Assaf Zemel, Avinoam Ben-Shaul and Sylvio May, "Perturbation of a lipid membrane by amphipathic peptides and its role in pore formation", Eur. Biophys. J., 34: 230-243 (2005)

31. Emmanuel C. Mbamala, Avinoam Ben-Shaul, and Sylvio May, "Domain Formation Induced by the Adsorption of Charged Proteins on Mixed Lipid Membranes", Biophys. J., 88: 1702-1714 (2005)

30. Klemen Bohinc, Ales Iglic and Sylvio May, "Interaction between Macroions Mediated by Divalent Rod-like Ions", Europhys. Lett., 68 (4), 494-500 (2004)

29. Sylvio May, Yoni Kozlovsky, Avinoam Ben-Shaul and Misha Kozlov, "Tilt modulus of a lipid monolayer",, Eur.Phys.J.E, 14, 299-308 (2004)

28. Cristina Luminita Baciu and Sylvio May, "Stability of charged, mixed lipid bilayers: Effects of electrostatic coupling between the monolayers", J.Phys. Condens Matter, 16 S2455-S2460 (2004)

27. Assaf Zemel, Avinoam Ben-Shaul and Sylvio May, "Membrane Perturbation Induced by Interfacially Adsorbed Peptides", Biophys. J., 86, 3607-3619 (2004)

26. Sylvio May and Avinoam Ben-Shaul, "Modeling of cationic lipid-DNA complexes", Current Medicinal Chemistry, 11, 1241-1253 (2004)

25. Miha Fosnaric, Veronika Kralj-Iglic, Klemen Bohinc, Ales Igic and Sylvio May, "Stabilization of Pores in Lipid Bilayers by Anisotropic Inclusions", J.Phys.Chem.B, 107(45), 12519-12526 (2003)

24. Klemen Bohinc, Veronika Kralj-Iglic and Sylvio May, "Interaction between two cylindrical inclusions in a symmetric lipid bilayer", J.Chem.Phys., 119(14), 7435-7444 (2003)

23. Daniel Harries, Sylvio May and Avinoam Ben-Shaul, "Curvature and charge modulations in lamellar DNA-lipid complexes", J.Phys.Chem.B, 107(15), 3624-3630 (2003)

22. Sylvio May and Avinoam Ben-Shaul, "Membrane-Macromolecule Interactions and their Structural Consequences", Chapter 10 in "Membrane Science and Technology, Vol. 7: Planar Lipid Bilayers (BLMs) and their Applications", edited by H.T.Tien and A.Ottova-Leitmannova, Elsevier, 2003, pages 315-346

21. Sylvio May, Daniel Harries and Avinoam Ben-Shaul, "Macroion-induced compositional instability of binary fluid membranes", Phys.Rev.Lett., 89, 268102 (2002)

20. Sylvio May, "Structure and energy of fusion stalks: The role of membrane edges", Biophys. J., 83, 2969-2980 (2002)

19. Sylvio May, "Membrane Perturbations Induced by Integral Proteins: Role of Conformational Restrictions of the Lipid Chains" Langmuir 18(16), 6356-6364 (2002)

18. Daniel Harries, Sylvio May and Avinoam Ben-Shaul, "Adsorption of Charged Macromolecules on Mixed Fluid Membranes", Colloids and Interfaces A, 208, 41-50 (2002)

17. Amit Kessel, Nir Ben-Tal and Sylvio May, "Interactions of Cholesterol with Lipid Bilayers: The Preferred Configuration and Fluctuations", Biophys. J., 81, 643-658 (2001)

16. Sylvio May and Avinoam Ben-Shaul, "Molecular Theory of the Sphere-to-Rod Transition and the Second CMC in Aqueous Micellar Solutions", J.Phys.Chem.B, 105, 630-640 (2001)

15. Sylvio May, "Theories on structural perturbations of lipid bilayers", Curr. Opin. Coll. Int. Sci., 5, 244-249 (2000)

14. Sylvio May and Avinoam Ben-Shaul, "A molecular model for lipid-mediated interaction between proteins in membranes", Phys. Chem. Chem. Phys, 2, 4494-4502 (2000)

13. Sylvio May, Daniel Harries and Avinoam Ben-Shaul, "Lipid Demixing and Protein-Protein Interactions in the Adsorption of Charged Proteins on Mixed Membranes", Biophys.J., 79, 1747-1760 (2000)

12. Sylvio May, "A molecular model for the line tension of lipid membranes", Eur.Phys.J, E, 3, 37-44 (2000)

11. Sylvio May, "Inclusion induced bilayer deformations: The lipid tilt degree of freedom", Eur.Biophys.J, 29, 17-28 (2000)

10. Markus Deserno, Christian Holm and Sylvio May, "Fraction of condensed counterions around a charged rod: Comparison of Poisson-Boltzmann theory and computer simulations", Macromolecules, 33, 199-205 (2000)

9. Sylvio May, Daniel Harries and Avinoam Ben-Shaul, "The Phase Behavior of Cationic Lipid-DNA Complexes", Biophys J., 78, 1681-1697 (2000)

8. K. Wagner, D. Harries, S. May, V. Kahl, J.O Radler and A. Ben-Shaul, "Direct evidence for counterion Release upon Cationic Lipid-DNA Condensation", Langmuir, 16, 303-306 (2000)

7. Sylvio May and Avinoam Ben-Shaul, "Molecular Theory of Lipid-Protein Interaction and the L-HII transition", Biophys.J., 76, 751-767 (1999)

6. Daniel Harries, Sylvio May, William Gelbart and Avinoam Ben-Shaul, "Structure, Stability and Thermodynamics of Lamellar DNA-Lipid Complexes", Biophys.J., 75, 159-173 (1998)

5. Sylvio May and Avinoam Ben-Shaul, "DNA-Lipid Complexes: Stability of Honeycomb-like and Spaghetti-like Structures" Biophys.J. 73, 2427-2440 (1997),

4. Sylvio May , Yardena Bohbot and Avinoam Ben-Shaul, "Molecular Theory of Bending Elasticity and Branching of Cylindrical Micelles", J.Phys.Chem. B, 101, 8648-8657 (1997)

3. Sylvio May, "Curvature elasticity and thermodynamic stability of electrically charged membranes", J.Chem.Phys. 105, 8314 (1996)

2. Sylvio May and Avinoam Ben-Shaul, "Spontaneous curvature and thermodynamic stability of mixed amphiphilic layers", J.Chem.Phys. 103, 3839 (1995)

1. Sylvio May, "Position of the neutral surface in charged monolayers", Progr. Colloid. Polym. Sci. 97, 9-11 (1994)

h-factor: 27 (based on Web of Science)


2009 -- Spring -- PHYS 212 -- College Physics II  
2013 -- Spring -- PHYS 120 -- Fundamentals of Physics  
2012 -- Fall -- PHYS 120 -- Fundamentals of Physics  
2011 -- Fall -- PHYS 455 -- Classical Mechanics  
2011 -- Spring -- PHYS 212 -- College Physics II  
2010 -- Fall -- PHYS 462 -- Heat and Thermodynamics  
2010 -- Spring -- PHYS 212 -- College Physics II  
2009 -- Fall -- PHYS 455 -- Classical Mechanics  

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Last Updated: Monday, December 29, 2014 1:27:22 PM