At the US Naval Research Laboratory (NRL), we have used pulsed lasers to process thin films and multilayers of almost all classes of materials from electronic ceramics for microwave devices to engineered tissue constructs. The novelty of processing materials this way starts with a fundamental understanding of the laser-material interaction and energy relaxation pathways and then exploiting the unique properties of lasers and materials to produce a vapor unobtainable by conventional physical or chemical methods. Recently, we have developed a new CAD/CAM technique for the soft laser forward transfer of a very large variety of materials called MAPLE DW for Matrix Assisted Pulsed Laser Evaporation Direct Write. The novelty in this approach is found in the laser-matrix interaction that results in a highly focused and soft material transfer. For electronic materials, this quality allows MAPLE DW to be able to transfer reproducible voxels of micron-size powders, nanoparticles, and organometallic precursors. The transfers take place at room temperature and in ambient air and we have demonstrated the mesoscopic scale (10 microns - 1 cm) fabrication of simple passive electronic devices (conductors, dielectrics, and resistors) and small sub-systems (x-band band pass filter) at low temperatures on plastic substrates (kapton). The electrical transport properties of all these component devices were comparable to more conventional thick film techniques such as screen-printing. Because of MAPLE DW's gentle nature this technique was also found to be successful in depositing patterns of viable biomaterials such as proteins, bacteria, and mammalian cells. When transferred as single layers, the cells spread out and multiply, but when deposited on top of one another they assemble and grow slowly together behaving more like natural tissue. The fabrication of three-dimensional tissue constructs that more closely replicates the heterogeneous structure of natural tissue may now be envisioned. This presentation will give an overview of the novel laser processing work being done at NRL and the fundamental science and engineering questions being answered as well as specific examples of technology being transferred to address next generation military and commercial applications.