Jane Schuh

Associate Professor

Van Es 187G
701 231 7841
jane.schuh@ndsu.edu

Associate Director for the ND Ag Experiment Station and Coordinator/Director of the Cellular and Molecular Biology interdisciplinary graduate program

Education

  • Ph.D. in Cellular and Molecular Biology from North Dakota State University
  • Postdoctoral Fellowship in Pathology at the University of Michigan Medical School

Teaching Interests

  • MICR 770 The Immunology of Chronic Infections

I am an immunologist, and I believe that understanding the host’s response to a pathogen is a hugely important aspect of microbiology. I teach an advanced immunology class (MICR 770) that deals with the “big three” infectious disease killers in the world today—TB, HIV/AIDS, and malaria. I also help with graduate classes on the responsible conduct of research and professional development. I love teaching about immunology. From the things that our immune system does every day that prevent infection to eliminating pathogens that hide inside the very cells that are supposed to kill them...our immune system is fascinating. It’s helping (and sometimes hurting) us every day. I got a firsthand look at transplant immunology a couple of years ago when I donated part of my liver to an unrelated recipient. As an immunologist, I think that is totally cool!! (The drug reaction that I had to the pain medication was not so cool, but still fascinating.)

Research Interests

Our lab researches the interaction between the inflammatory cells and the resident cells and architecture of the allergic lung when a person is repeatedly exposed to mold spores. We have developed an animal model that closely mimics the human disease using the inhalation of Aspergillus fumigatus spores. A. fumigatus is found nearly everywhere and is responsible for a huge number of the mold-induced diseases of humans. The severity of these diseases can range from respiratory allergies to deadly invasive disease. The tiny, dark green spores are made by the billions, are very resistant to drying, and can stay airborne for long periods of time. When a person with a normal immune system inhales Aspergillus spores (s)he clears them very quickly. However, regular exposures or high-dose exposures can provoke allergies, and inhalation of the fungus can be life-threatening in people with an impaired immune system. Recently, we have built a collaboration with researchers at the University of Utah and ARUP National Reference Laboratory to develop an ultra-sensitive diagnostic test for Invasive Aspergillosis.

The Lab - The Department - The College

The Immunology Laboratory is part of the Department of Veterinary and Microbiological Sciences, which is housed in the College of Agriculture, Food Systems, and Natural Resources. While this may not seem to be a logical progression to some, it has been a tremendous opportunity to use our expertise for outreach and research to impact the state in a meaningful way. I employ a number of talented undergraduate and graduate students in my research program. Not only do these students work at the lab bench to ask (and answer) the questions about how microorganisms impact our health, they are also volunteers who do outreach and training programs with local grade schools and high schools. We all have the very good fortune of working with Mr. Scott Hoselton who is the Research Specialist in the lab. His background and dedication is invaluable to our progress in understanding fungal respiratory disease.

I also fill a part-time position working with academic programs in the College. It is humbling to see the universal dedication that the faculty across the college have for student success.

Other Things

I was born into a family of 12 and grew up on a farm outside of Sheldon, North Dakota. My dad was a farmer and a teacher, and education was always a very important part of my life. I am an alum of NDSU (Go, Bison!) where I studied zoology as an undergraduate and earned my Ph.D. in Cellular and Molecular Biology with an emphasis in immunology. I spent 4 years at the University of Michigan Medical School for postdoctoral training in lung pathology. At Michigan, I studied in the lab of another NDSU alum, Steven Kunkel, who has been both a mentor and an inspiration.

I love to cook...and eat. My husband and I enjoy entertaining, especially in the summer when the patio is an option and the grill is sizzling. I have two great kids that I am ridiculously proud of. I sing...mostly in the car or shower, but occasionally with my church’s funeral choir...I’m best in a group. I have recently rediscovered oil painting...more for therapy than for art. I have always loved reading, particularly fiction, which was the best gift my dad ever gave me.

Publications

    Peer-reviewed journal articles (first author is the main research contributor; last author is considered the senior author; undergraduate researchers*)

    Sumit Ghosh, Scott A. Hoselton, Steve B. Wanjara, Jennifer Carlson, James B. McCarthy, Glenn P. Dorsam, Jane M. Schuh. Hyaluronan stimulates ex vivo B lymphocyte chemotaxis and cytokine production in a murine model of fungal allergic asthma. Immunobiology. 2015 Feb 7. Pii:S0171-2985(15)00019-4. doi: 10.1016/j.imbio.2015.01.011.

    Sumit Ghosh, Scott A. Hoselton, Glenn P. Dorsam, Jane M. Schuh. Hyaluronan fragments as mediators of inflammation in allergic pulmonary disease. Immunobiology. 2015 May;220(5):575-588. doi: 10.1016/j.imbio.2014.12.005.

    Sumit Ghosh, Scott A. Hoselton, Scott V. Asbach, Breanne N. Steffan, Steve B. Wanjara, Glenn P. Dorsam, Jane M. Schuh. B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma. Cellular and Molecular Immunology. 2015 Mar;12(2):202-12. doi: 10.1038/cmi.2014.103.

    Sumit Ghosh, Amali E. Samarasinghe, Scott A. Hoselton, Glenn P. Dorsam, and Jane M. Schuh.Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma. Inflammation Research. 2014 Jun;63(6):475-84. Doi:10.1007/s00011-014-0719-3. Epub 2014 Feb 12. PMC4020973

    Amali Samarasinghe, Stacie N. Woolard, Kelli L. Boyd, Scott A. Hoselton, Jane M. Schuh, and Jonathan A. McCullers. The immune profile associated with acute allergic asthma accelerates clearance of influenza virus. Immunology and Cell Biology. 2014 May-Jun;92(5):449-59. Doi:10.1038/icb.2013.113. Epub 2014 Jan 28.PMC4037497

    Sumali Pandey, Scott A. Hoselton, and Jane M. Schuh. The impact of Aspergillus fumigatus viability and sensitization to its allergens on the murine allergic asthma phenotype.BioMed Research International. 2013;2013:619614. Epub 2013 Aug 26. PMC3770015

    Sumit Ghosh, Scott A. Hoselton, Glenn P. Dorsam, and Jane M. Schuh.Eosinophils in fungus-associated allergic pulmonary disease.Frontiers in Pharmacology. 2013 Feb 1;4:8. eCollection 2013. PMC3561640.

    Sumit Ghosh, Scott A. Hoselton, and Jane M. Schuh. Characterization of CD19+ CD23+ B2 lymphocytes in the allergic airways of BALB/c mice in response to the inhalation of Aspergillus fumigatus conidia. Open Immunology Journal, 2012 Dec 28;5:46-54. PMC3540783

    Sumit Ghosh, Scott A. Hoselton, and Jane M. Schuh. µ-Chain-deficient mice possess B-1 cells and produce IgG and IgE, but not IgA, following systemic sensitization and inhalation challenge in a fungal asthma model. Journal of Immunology, 2012 Aug 1;189(3):1322-9. PMC3401271

    Emily E. Vomhof-DeKrey, Ashley R. Sandy*, Jarrett J. Failing*, Rebecca J. Hermann, Scott A. Hoselton, Jane M. Schuh, Abby J. Weldon, Kimberly J. Payne, and Glenn P. Dorsam. Radical reversal of Vasoactive Intestinal Peptide receptors during early lymphopoiesis. Peptides. 2011 Oct;32(10):2058-66. Epub 2011 Aug 22. PMC3196295

    Amali E. Samarasinghe, Scott A. Hoselton, and Jane M. Schuh. A comparison between intratracheal and inhalation delivery of Aspergillus fumigatus conidia in the development of fungal allergic asthma in C57BL/6 mice. Fungal biology. 2010 Jan; 115(1):21-9. PMC3053007

    Amali E. Samarasinghe, Scott A. Hoselton, and Jane M. Schuh. The absence of VPAC2 leads to aberrant antibody production in Aspergillus fumigatus sensitized and challenged mice. Peptides. 2010 Jun; 31(6):1068-75. PMC3299058.

    Glenn P. Dorsam, Scott A. Hoselton, Ashley R. Sandy*, Amali E. Samarasinghe, Sheri T. Dorsam, Emilie E. Vomhof-DeKrey, and Jane M. Schuh. Gene expression profiling and network analysis of peripheral blood monocytes in a chronic model of allergic asthma. Microbiology and Immunology. 2010; 54: 558-63. PMC3102558.

    Amali E. Samarasinghe, Scott A. Hoselton, and Jane M. Schuh. Spatio-temporal localization of vasoactive intestinal peptide and neutral endopeptidase in allergic murine lungs. Regulatory Peptides. 2010 Sept 24; 164(2-3):151-7. PMC2926301.

    Scott A. Hoselton, Amali E. Samarasinghe, Jena M. Seydel*, and Jane M. Schuh. An inhalation model of airway allergic response to inhalation of environmental Aspergillus fumigatus conidia in sensitized BALB/c mice. Medical Mycology 2010 Dec; 48(8):1056-65. PMC3113699.

    Amali E. Samarasinghe, Scott A. Hoselton, and Jane M. Schuh. The absence of VPAC2 receptor does not protect mice from Aspergillus induced allergic asthma. Peptides. 2010 Jun; 31(6):1068-75. PMC2873113.

    Nora J. Lin, Jane M. Schuh, and Cory M. Hogaboam. Maintenance of Airway hyperresponsiveness in chronic asthma may be mediated by Th2-independent mechanisms. The Open Allergy Journal. Pp. 12-18(7). doi: 10.2174/1874838400801010012. 2008.

    Scott A. Hoselton, Amali E. Samarasinghe, Jena L. Seydel*, Kayla M. Serie*, and Jane M. Schuh. 2007. Creation and characterization of an IgG1-type monoclonal antibody against intact Aspergillus fumigatus conidia. Hybridoma. 26(4):251-4.

    19.Cory M. Hogaboam, Kristin J. Carpenter, Jane M. Schuh, and Karen F. Buckland. 2005. Aspergillus and asthma—any link? Medical Mycology. 43(s1):S197-202.

    Cory M. Hogaboam, Kristin J. Carpenter*, Jane M. Schuh, Amanda A. Proudfoot, Gary Bridger, and Karen F. Buckland. 2005. The therapeutic potential in targeting CCR5 and CXCR4 receptors in infectious and allergic pulmonary disease. Pharmacological Therapy. 107(3):314-3128.

    Kristin J. Carpenter*, Jillian L. Ewing, Jane M. Schuh, Traci L. Ness, Steven L. Kunkel, Monica Aparici, Montserrat Miralpeix, and Cory M. Hogaboam. 2005. Therapeutic targeting of CCR1 attenuates established chronic fungal asthma in mice. British Journal of Pharmacology. 145(8):1160-1172.

    Cory M. Hogaboam, Kazue Takahashi, R. Alan B. Ezekowitz, Steven L. Kunkel, and Jane M. Schuh. 2004. Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile. Journal of Leukocyte Biology. 75(5):805-14.

    Cory M. Hogabaom, Kate Blease, and Jane M. Schuh. 2003. Cytokines and chemokines in allergic bronchopulmonary aspergillosis (ABPA) and experimental Aspergillus-induced allergic airway or asthmatic disease. Frontiers in Bioscience. 8:E147-E156.

    Jane M. Schuh, Kate Blease, Hilke Bruhl, Matthias Mack, and Cory M. Hogaboam. 2003. Intrapulmonary targeting of RANTES/CCL5-responsive cells prevents chronic allergic airway disease induced by Aspergillus fumigatus. European Journal of Immunology. 33(11):3080-90.

    Jane M. Schuh, Kate Blease, Steven L. Kunkel, and Cory M. Hogaboam. 2003. Cytokines and Chemokines: axis and allies in allergic fungal asthma. Cytokines and Growth Factor Reviews. 14(6):503-10.

    Jane M. Schuh, Kate Blease, Steven L. Kunkel, Christine A. Power, Amanda Proudfoot, Nicholas W. Lukacs, and Cory Hogaboam. 2002. Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4-/- mice. FASEB Journal. 16(10):1313-5.

    Jane M. Schuh, Kate Blease, Steven L. Kunkel, and Cory M. Hogaboam. 2002. Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus. American Journal of Physiology-Lung Cellular and Molecular Physiology. 283(1):L198-204.

    Jane M. Schuh, Kate Blease, and Cory M. Hogaboam. 2002. The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice. FASEB Journal. 16(2):228-30.

    Jane M. Schuh, Kate Blease, and Cory M. Hogaboam. 2002. CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice. Journal of Immunology. 168(3):1447-56.

    Kate Blease, Jane M. Schuh, Claudia Jakubzick, Nicholas W. Lukacs, Steven L. Kunkel, Bharat H. Joshi, Raj K. Puri, Mark H. Kaplan, and Cory M. Hogaboam. 2002. Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. American Journal of Pathology. 160(2):481-90.

    Kate Blease, Claudia Jakubzick, Jane M. Schuh, Bharat H. Joshi, Raj K. Puri, and Cory Hogaboam. 2001. IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic airway disease in mice. Journal of Immunology. 167(11):6583-92.

    Invited book chapters

    1. Jane M. Schuh and Scott A. Hoselton. 2013. An inhalation model of allergic fungal asthma: Aspergillus fumigatus-induced inflammation and remodeling in allergic airway disease. In Allen (Ed.), Mouse Models of Allergic Disease: Methods and Protocols. Methods of Molecular Biology, vol. 1032. New York; Springer Humana Press, p.173-84.
    1. Jane M. Schuh and Cory M. Hogaboam. 2005. The innate and acquired immune response to Aspergillus fumigatus. In Fidel and Huffnagle (Eds.), Fungal Immunology from an Organ Perspective. New York; Kluwer Academic Publishers, p. 229-40.
    2. Jane M. Schuh, Steven L. Kunkel, Nicholas W. Lukacs, and Cory M. Hogaboam. 2003. Mice knockouts for chemokines and chemokine receptors. In Giamila Fantuzzi (Ed.), Cytokine Knockouts, second edition. Totowa, NJ: Humana Press, p. 323-45.
    1. Cory M. Hogaboam, Jane M. Schuh, Alison E. John, and Nicholas W. Lukacs. 2003. The role of chemokines in asthmatic airway responses. In Robert M. Streiter, Steven L. Kunkel, and Theodore J. Standiford (Eds.),Chemokines in the Lung. New York: Marcel Dekker. p. 81-98.