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Gregory R. Cook

Synthetic Organic and Medicinal Chemistry

The research efforts in our group are directed toward the development of new reactions that will assist us in the synthesis of biologically important molecules. Our synthetic targets include compounds that are found in nature, as well as unnatural compounds, which display potential therapeutic properties. Some of the disease states that we emphasize are cancer, HIV, arthritic, and other autoimmune dieseases. Our projects fall into three main categories: 1) new organic reactions mediated by eco-friendly indium and bismuth reagents and catalysts, 2) development of new asymmetric catalysts, and 3) synthesis of biologically active molecules including anti-cancer and anti-alzheimers agents.

Selected Publications

“Chapter 21. Ring Closing Friedel-Crafts Reactions”
Hayashi, Ryuji; Cook, Gregory R.
“Handbook of Cyclization Reactions” Ma, S., Ed.; 2009, Wiley-VCH. ISBN: 978-3-527-32088-2

"Asymmetric Synthesis of Aminochromanes via Intramolecular Indium-Mediated Allylation of Chiral Hydrazones"
Samanta, Debasis; Kargbo, Robert B.; Cook, Gregory R.
J. Org. Chem. 2009, 74, 7183-7186.

“Binding of Matrix Metalloproteinase Inhibitors to Extracellular Matrix: 3D-QSAR Analysis”
Zhang, Y.; Lukacova, V.; Bartus, V.; Nie, X.; Sun, G.; Manivannan, E.; Ghorpade, S. R.; Jin, X.; Manyem, S.; Sibi, M. P.; Cook, G. R.; Balaz, S.
Chem. Biol. Drug Des. 2008, 72, 237-248.

"Bi(OTf)3-Catalyzed 5-exo-trig Cyclization via Halide Activation”
Hayashi, Ryuji, Cook, Gregory R.
Tetrahedron Lett. 2008, 49, 3888-3890.

“Synthesis and Evaluation of Novel Heterocyclic MMP Inhibitors”
Hayashi, Ryuji; Jin, Xiaomin, Cook, Gregory R.
Bioorg. Med. Chem. Lett. 2007, 17, 6864-6870.

“Intermolecular Friedel-Crafts Reaction Catalyzed by InCl3”
Kaneko, Miho; Hayashi, Ryuji; Cook, Gregory R.
Tetrahedron Lett. 2007, 48, 7085-7087.

“Readily Accessible, Modular and Tuneable BINOL 3,3'-Perfluoroalkylsulfones: Highly Efficient Catalysts for Enantioselective In-Mediated Imine Allylation”
Kargbo, Robert; Takahashi, Yoko; Bhor, Santosh; Cook, Gregory R.; Lloyd-Jones, Guy C.; Shepperson, Ian R.
J. Am. Chem. Soc. 2007, 129, 3846-3847.

"Remarkably Mild and Efficient Intramolecular Friedel-Crafts Cyclization Catalyzed by In(III)”
Hayashi, Ryuji; Cook, Gregory R.
Org. Lett. 2007, 9, 1311-1314.

“Drug-membrane Interactions Studied in Phospholipid Monolayers Adsorbed on Non-porous Alkylated Microspheres”
Lukacova, V.; Peng, M.; Fanucci, G.; Tandlich, R.; Hinderliter, A.; Maity, B. Manivannan, E.; Cook, Gregory R.; Balaz, S.
J. Biomolecular Screening 2007, 12, 186-202.

"Stereoselective Indium-Mediated Organic Reactions "
Kargbo, R. B. and Cook, G. R.
Current Organic Chemistry, 2007, 11, 1287.

Professor and Chair

BA, Olivet College, 1988
PhD, Michigan State University, 1994
NIH Postdoctoral Fellow, Stanford University, 1994-1996

Office: Dunbar 360A, Ladd 104G
tel 701-231-7413
fax 701-231-8831

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