Research

We have conducted studies in a variety of species (primarily sheep, swine, and cattle) focused on understanding how the following factors/stressors influence fertility (the ability to conceive and establish a pregnancy) as well as fetal and postnatal growth and development, and therefore health and productivity of the offspring:

  • Maternal nutritional intake around the time of conception
  • Maternal nutritional intake during pregnancy
  • Specific nutrients, such as selenium, protein and one-carbon metabolites, in the maternal diet
  • Maternal nutritional intake during early lactation
  • Maternal activity/exercise
  • Maternal exposure to steroid hormones (e.g., corticoids, estrogens)
  • Maternal age (e.g., adolescent or aged pregnancies)
  • Maternal or fetal genotype
  • Singleton vs. multiple fetuses/offspring
  • Sex of the fetus/offspring
  • Assisted reproductive techniques including in vitro fertilization and cloning

Current and Past Research Projects of the CNP (PIs and Co-PIs listed) 

  1. Ward, Alison (Project Director), Caton, Joel (Co-PD), Dahlen, Carl (Co-PD) and Crouse, Matt (Co-PD), Borowicz PP (Co-Investigator), Reynolds LP (Co-I) “Maternal Nutrition, Epigenetic Modifiers, and Programming of Fetal Organ Development in Beef Cattle,” National Institute of Food and Agriculture, U.S. Department of Agriculture, Federal, $500,000. (2020 - 2025).
  2. Reynolds LP (Principal), Borowicz PP (Co-Investigator), Caton JS (Co-I), Dahlen CR (Co-I), Ward AK (Co-I), Conley A (Collaborator), Coy P (Collaborator), Cushman R (Collaborator), “Strategies to Improve Fertility and Pregnancy Outcomes in Ruminant Livestock,” USDA Hatch Project, salary support for PI and Co-Is and operating funds, February 2019-January 2024
  3. Reynolds LP (Principal), Borowicz, Pawel (Co-Principal), Caton, Joel (Co-Principal), Dahlen, Carl (Co-Principal), Ward, Alison (Co-Principal), “Does maternal nutrition alter gene expression in placenta of beef heifers?,” North Dakota State Board of Agricultural Research and Education, $28,106.00. (2019 - 2020).
  4. Reynolds LP (Co-Investigator), PHS Grant NIH R25 HD 080632, “Frontiers in Reproduction;” $1,153,401 total direct costs; July 2014-June 2019
  5. Reynolds LP, Caton JS, USDA Hatch Project, “Regulation of Fertility in Ruminant Livestock;” salary support for PIs and operating funds, December 2013-September 2018
  6. Ominski, Kim (Principal), Bauer, Marc (Co-Principal), Dahlen, Carl (Co-Principal), Reynolds LP (Co-Principle), Swanson, Kendall (Co-Principal), Stokka, Gerald (Co-Principal), Vonnahme, Kimberly (Co-Principal)Ward, Alison (Co-Principal), "Impact of Winter Feeding and Vaccination Strategies on Carcass Outcomes in Beef Cattle", National Sciences and Engineering Council; Manitoba Beef and Forage Initiatives, Inc. Manitoba Beef Producers, $67,085.00. (2015 - 2017).
  7. Caton, Joel (Principal), Dahlen, Carl (Co-Principal), Reynolds LP (Co-Investigator), McLean, Kyle (Other: Graduate Student), Borowicz, Pawel (Senior Personnel), Neville, Brian (Senior Personnel), "Role of Endogenous Retroviruses and Nutritional Management in Placental Syncytium Formation during Early Gestation,” National Institute of Food and Agriculture, U.S. Department of Agriculture, Federal, $150,000. (2015 - 2017).
  8. Ominski K (Principal), Reynolds LP (Co-Investigator), Vonnahme K (Co-I), “Impact of cow-calf feeding and vaccination strategies on carcass outcomes in beef cattle.” Manitoba Agriculture, Food and Rural Initiatives, $261,000, 2015-17.
  9. Stokka, Gerald (Principal), Reynolds LP (Co-Principal), Swanson, Kendall (Co-Principal), Bauer, Marc (Co-Principal), Berg, Eric (Co-Principal), Dahlen, Carl (Co-Principal), , Ward, Alison (Co-Principal), Vonnahme, Kimberly (Co-Principal), "Impact of winter feeding strategies during gestation on productivity and carcass outcomes in beef cattle: calf health through weaning,” North Dakota State Board of Agricultural Research and Education, $18,000.00. (2016 - 2017).
  10. Vonnahme, Kimberly (Principal), Reynolds LP (Co-Principal), Swanson, Kendall (Co-Principal), Stokka, Gerald (Co-Principal), Bauer, Marc (Co-Principal), Berg, Eric (Co-Principal), Dahlen, Carl (Co-Principal), Ward, Alison (Co-Principal), "Impact of winter feeding strategies during gestation on productivity and carcass outcomes in beef cattle: Uterine blood flow to the developing calf,” North Dakota State Board of Agricultural Research and Education, $16,400.00. (2016 - 2017).
  11. Reynolds LP, Fulbright Senior Scholar Award to teach and establish research at University of Murcia, Spain (Animal Physiology Department, Faculty of Veterinary Medicine), $12,871. (September-December, 2017).
  12. Reynolds LP and Grazul-Bilska AT, PHS Grant R03HD076073, “Steroid receptors in placental tissue and vasculature during early pregnancy;” $100,000 total direct costs, April 2014-March 2016
  13. Reynolds LP and Conley AJ, Academic Scholarship Fund, Society for Reproduction and Fertility, “Steroids in regulation of parturition, fetal maturation, and placental expulsion in cows;” £10,000 (approx. $16,000); November 2014-January 2016
  14. Reynolds LP and Conley AJ, USDA-AFRI Grant, “Role of placental, fetal adrenal and fetal neural steroids in parturition and extra-uterine survival;” $131,396 total direct costs, September 2013-August 2015
  15. O’Rourke ST, PHS Grant NHLBI R03-HD061532-01-02, “Undernutrition in Pregnancy and Developmental Programming of Vascular Function”; $100,000 total direct costs, September 2009-August 2013
  16. Reynolds LP, Redmer DA, USDA Hatch Project, “Angiogenesis and Reproduction in Livestock;” salary support for PIs and operating funds, January 2007-September 2012
  17. Reynolds LP, Redmer DA, Wallace JM, PHS Grant R01HD045784-05S2, “Administrative Supplement” (Parent Grant, NICHD 45784-01-05 "Nutrition, fetal growth, and placental angiogenesis"); $197,514 total direct costs, August 2010-July 2012
  18. Reynolds LP and Grazul-Bilska AT, USDA, NRI Grant 2007-01215, “Epigenetics of placental angiogenesis in cloned and monoparental sheep fetuses”; $315,000 total direct costs, September 2007-August 2011
  19. Reynolds LP, Redmer DA, Wallace JM, PHS Grant NICHD 45784-01-05 "Nutrition, fetal growth, and placental angiogenesis"; $1,210,000 total direct costs; April 2005-March 2011
  20. Reynolds LP, Redmer DA, Wallace JM, PHS Grant R01HD045784-05S1, “Summer Research Experience” (Parent Grant, NICHD 45784-01-05 "Nutrition, fetal growth, and placental angiogenesis"; $4,302 total direct costs, June 2009-October 2009
  21. Reynolds LP, Myatt L, Hay W, USDA, NRI Conference Grant – Aspen Perinatal Biology Symposium, “Interaction of Maternal, Placental and Fetal Systems in Perinatal Development”; $10,000 total direct costs, July 2007-August 2008
  22. Reynolds LP, Magness RR, Hay W, USDA, NRI Conference Grant – FASEB Summer Research Conference “Molecular & Cellular Signaling in the Perinatal Cardiovascular System”; $10,000 total direct costs, August 2004-July 2005
  23. Reynolds LP, Redmer DA, PHS Grant NHLBI 64141-01-04 "The major angiogenic factors in placental angiogenesis"; $425,000 total direct costs; February 2001-January 2005

 

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