NDSU Calendar

Thursday, February 7, 2013
4:00pm
Department of Chemistry and Biochemistry (Conference/Workshop/Seminar)

Gregory K. Friestad, Department of Chemistry, University of Iowa, will present a seminar entitled, "Taming Free Radicals and Carbocations for Asymmetric Synthesis of Bioactive Compounds".
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Everyone is welcome!
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Abstract:
Carbon-centered free radicals and carbocation intermediates are commonly presumed to exhibit poor stereochemical control, and this is considered an impediment to synthetic applications. Our program challenges this notion, focusing on the discovery and application of new synthetic methods which expand the scope of asymmetric synthesis using radicals and carbocations. For example, we have discovered and developed a remarkably versatile and stereoselective Mn-mediated free radical addition raction of alkyl iodides and N-acylhydrazones for preparation of chiral amines. The lecture will include applications of the Mn-mediated radical addition in synthetic routes to the natural products quinine (antimalarial agent) and tubulysin D (antimitotic agent), discovery of a new type of radical-polar crossover reaction, and implementation of a new stategy for 1,5-polyol synthesis.
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More information...
Location: Ladd 107
Price: Free
Host: Department of Chemistry and Biochemistry
Contact: Wendy J. Leach
E-Mail: wendy.leach@ndsu.edu

701-231-8694

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