Department of Chemistry and Biochemistry with co-sponsor, Center for Life Sciences (Conference/Workshop/Seminar)
Michael Sehorn, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, will present a seminar entitled, "Mechanism of Homologous Recombination".
Everyone is welcome!
Homologous recombination (HR) is critical to the maintenance of the genome. HR is utilized to repair DNA double strand breaks (DSB) induced by ionizing radiation, alkylating agents and damaged DNA replication forks. During meiosis, HR creates crossovers between homologous chromosomes to ensure their proper segregation. Defective HR can lead to cell death, mutations, cancer and many other diseases including disorders associated with immune dysfunction, neurodegeneration and premature aging. The repair of a DSB by HR requires nucleolytic processing of the DSB to yield single-strand DNA (ssDNA) tails that serve as the nucleation site for the Rad51 and Dmc1 recombinases. The recombinases from an ATP dependent nucleoprotein filament on ssDNA called a presynaptic filament that invades a homologous chromosome in search of homology. Once homology is found, base pairing with the complementary strand in the homologue results in formation of a displacement loop. This process is greatly enhanced by accessory factors. Our data reveal a previously unknown role in HR for a Swi2/Snf2 family member involved in epigenetic modulation. More information...
Department of Chemistry and Biochemistry and Center for Life Sciences, co-sponsor
Wendy J. Leach email@example.com
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