Department of Chemistry and Biochemistry with co-sponsor, Center for Protease Research (Conference/Workshop/Seminar)
Roxanne A. Vaughan, Professor and Chester Fritz Distinguished Professor, Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, will present a seminar entitled, "Dopamine Transporter Structure and Regulation in Drug Abuse and Disease".
Everyone is welcome!
The dopamine transporter (DAT) is a neuronal protein that actively transports dopamine from the extracellular space back into presynaptic neurons, and as such regulates the spatial and temporal availability of dopamine during synaptic transmission. DAT is a major target for abused drugs such as cocaine and amphetamine, which inhibit reuptake and stimulate dopamine overflow. My research is focused on structure, function, and regulation of DATs and the role of these factors in dopaminergic disorders such as addiction, depression, and Parkinson's disease. We have focused on DAT post-translational modifications as mechanisms for regulation of DAT activity and stability, and determination of uptake inhibitor-protein interactions using irreversible analogs of cocaine and methylphenidate. More information...
Department of Chemistry and Biochemistry and Center for Protease Research, co-sponsor
Wendy J. Leach email@example.com
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