Department of Chemistry and Biochemistry (Conference/Workshop/Seminar)
Matthew Gage, Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ will present a seminar entitled, "Intrinsically Disordered Proteins: Understanding Function in the Absence of Structure".
Until recently, protein science has been dominated by the principle that a protein's function is dictated by its structure. This paradigm was turned upside down fifteen years ago when a class of proteins that are functional without measurable structure was identified. These proteins, referred to as Intrinsically Disordered Proteins (IDPs), have opened up exciting new possibilities in protein science. My talk will focus on recent studies from my lab on the FlgM protein, a model IDP that binds the transcription factor Sigma-28 to regulate flagella synthesis. One exciting principle that our work has uncovered is that, unlike well-ordered proteins, IDPs from the same protein family do not all exhibit similar structural characteristics. This discovery suggests that the principles that drive evolution of IDPs may differ from the principles that have been established for globular proteins. The diversity within the FlgM protein family offers exciting possibilities to explore this question in the future.
Everyone is welcome! More information...
Department of Chemistry and Biochemistry
Wendy J. Leach email@example.com
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