Department of Chemistry and Biochemistry and co-sponsor University of North Dakota, Department of Biochemistry and Molecular Biology (Conference/Workshop/Seminar)
Rajendra Prasad, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, will present a seminar entitled, "Multidrug Transporters in Clinical Drug Resistance".
Everyone is welcome!
Over-expression of human P-glycoprotein (P-gp) remains the most documented example of an ABC drup transporter responsible for the failure of chemotherapy in tumour cells. The presence of proteins homologous to P-gp in all other organisms ranging from prokaryotes to eukaryotes suggests that extrusion of drugs is a general mechanism of multidrug resistance. It is well-known that the enhanced expression of Cdr1 protein, a homologue of human P-gp, in azole resistant (AR) clinical isolates of the opportunistic human fungal pathogen "Candida albicans" leads to reduced accumulation of therapeutic azoles, which facilitates its survival.
Considering the importance of the Cdr1 protein as a major antifungal transporter and the fact that it has a novel mechanism of ATP hydrolysis and drug transport which is unique to all fungal transporters, our main objective is to understand the structure and function of Cdr1p to design inhibitors/modulators to block the protein's pump activity, so the drug already in use could again sensitize resistant Candida cells. An understanding of the mechanism underlying MDR is important for identifying new antifungal targets. Targeting MDRs at the level of transcriptional regulation represents another alternate strategy being pursued. More information...
Department of Chemistry and Biochemistry
Wendy J. Leach firstname.lastname@example.org
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