Center for Protease Research (Conference/Workshop/Seminar)
Jing Yang, Department of Pharmacology and Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, will present a seminar entitled, "Epithelial - Mesenchymal Plasticity in Carcinoma Metastasis".
Everyone is welcome!
Epithelial-Mesenchymal Transition (EMT) is implicated in converting stationary epithelial tumor cells into motile mesenchymal cells during metastasis. However, the involvement of EMT in metastasis is still controversial due to the lack of a mesenchymal phenotype in human carcinoma metastases. Using a spontaneous squamous cell carcinoma mouse model, we show that activation of the EMT-inducing transcription factor Twist1 is sufficient to promote carcinoma cells to undergo EMT and disseminate into blood circulation. Importantly, in distant sites, turning off Twist1 to allow reversion of EMT is essential for disseminated tumor cells to proliferate and form metastases. Our study demonstrates in vivo the requirement of "reversible EMT" in tumor metastasis and may resolve the controversy on the importance of EMT in carcinoma metastasis. This talk will also discuss the possibilities to target the EMT/MET program for anti-metastasis therapy considering the dynamic involvement of EMT in metastasis.
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Center for Protease Research
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