Department of Biological Sciences and co-sponsor listed below (Conference/Workshop/Seminar)
Costas A. Lyssiotis, Assistant Professor, Department of Molecular and Integrative Physiology and Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, will present a seminar entitled, "Heterocellular Metabolic Crosstalk in Pancreatic Tumors". See abstract below!
Everyone is welcome! Thank you for your support.
The Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer is co-sponsoring this seminar.
Pancreatic tumors are dynamic pseudo-organs that contain numerous cell types interacting to create unique physiology. A typical pancreatic tumor is made up largely of stromal fibroblasts and immune cell populations, rather than cancer cells. These non-malignant cells act collaboratively to create a dense fibrotic matrix that blocks cancer cells from accessing nutrients and oxygen by inhibiting vascularization. The cancer cells are thus in a state of near-starvation and must employ unorthodox methods to obtain nutrients to support their bioenergetic and biosynthetic needs. Our group has provided foundational work describing the cell autonomous reprogramming of metabolic processes in the cancer cells to facilitate survival and growth under these challenging circumstances. Beyond cell intrinsic metabolic alterations, pancreatic cancer cells also work cooperatively with non-cancer cells in the tumor microenvironment through the exchange of growth factors, signaling molecules and metabolites. Indeed, more recently our group found that pancreatic tumor associated fibroblasts directly support the metabolism of cancer cells by supplying the amino acid alanine and that this process facilitates tumor growth. This study will provide the framework of my talk. Then, I will describe new work illuminating the role of pancreatic tumor associated macrophages, how these cells create an immunosuppressive microenvironment, facilitate tumor growth and impair the efficacy of cancer targeted therapy through symbiotic metabolic crosstalk pathways with pancreatic cancer cells.
free and open to public
Biological Sciences & co-sponsor listed above!
Wendy J. Leach firstname.lastname@example.org
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