Dr. Teresa Bergholz and her former graduate student, Dr. Manoj Shah, have a new publication in Journal of Applied Microbiology that evaluates cross protection in Listeria monocytogenes under salt and bile stress. You can download a copy of the paper here.
Listeria monocytogenes encounters many different environmental stresses during transmission through the food supply. Here we show that the order of exposure to 2 different stresses (increased osmolarity and bile salts) significantly impacts how the pathogen responds to the stress. Exposure to osmotic stress then bile leads to increased lag phase, while exposure to bile then osmotic stress leads to growth inhibition and morphological changes to the cells. Combinations of compounds that effect the cell envelope and change osmolarity can be explored further for the ability to impair L. monocytogenes growth.