Elisabetta Liverani, PhD
Assistant Professor
222C Sudro Hall
p 701.231.1098
f 701.231.8333
Education
2003–2007: Ph.D. in Pharmacology, Department of Applied Sciences, University of the West of England, Bristol, UK
1995–2002: B.S. in Biological Sciences, University of Bologna, Italy
Teaching
PSCI 301, Biochemistry and Molecular Biology for Pharmacists
Research Interests
- Platelet function and regulation during inflammation
- The role of the P2Y12 signaling pathway in regulating platelet-lymphocyte interactions during sepsis
- Sex-related differences in platelet activity and regulation in patients with sepsis
- Sex-specific targeting of purinergic signaling pathways as novel drug-based therapies for the improved treatment of sepsis
Academic and Professional Appointments
2020–present: Assistant Professor of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND.
2016–2020: Instructor, Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA
2015–2016: Postdoctoral Research Scientist, Temple Lung Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA
2010–2015: Postdoctoral Fellow, Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA
2008–2010: Postdoctoral Fellow, William Harvey Research Institute, Queen Mary University of London, UK
Awards and Honors
2018 Abstract Award, 47th Annual Philadelphia Workshop on Hemostasis, Phila., PA
2018 Editorial Board Member, Journal of International Immunopharmacology
2016 Scientist Developmental Grant, American Heart Association (2016-20), $308,000
2015 Travel Award, Society of Leukocyte Biology
2015 Jeanette Piperno Memorial Award, Temple University, Philadelphia, PA
2012 Abstract Achievement Award, American Society of Hematology
Publications
https://www.ncbi.nlm.nih.gov/myncbi/1LwjUqsk869kW/bibliography/public/
Selected Publications
Albayati S., Vemulapalli H., Tsygankov A.Y., and Liverani E. P2Y12 blockade results in altered interaction between platelets and regulatory T cells during sepsis. October 2020. J Leukoc Biol. 2020 Nov 26;. doi: 10.1002/JLB.3A0220-097R. [Epub ahead of print] PubMed PMID: 33242353
Liverani E., Tursi S.A., Cornwell W.D., Mondrinos M.J., Sun S., Buttaro B.A., Wolfson M.R., Rogers T.J. Tükel Ç, and Kilpatrick L.E. Targeted protein Kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis. FASEB J. 2020 Feb;34(2):2497-2510. doi: 10.1096/fj.201900897R.
Vemulapalli H., Albayati S., Tsygankov A.Y., and Liverani E. ADP Exerts P2Y12 -Dependent and P2Y12 -Independent Effects on Primary Human T Cell Responses to Stimulation. J Cell Commun Signal. 2020 Mar;14(1):111-126. doi: 10.1007/s12079-019-00540-8. Epub 2019 Dec 5. PubMed PMID: 31808055
Liverani E., Mondrinos M.J., Sun S., Kunapuli S.P., and Kilpatrick L.E. Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis. PLoS ONE 2018 3(4):e0195379. doi: 10.1371/journal.pone.0195379
Liverani E. Lung injury during LPS-induced inflammation occurs independently of the receptor P2Y1. Purinergic Signalling 2017 13(1):119-125
Liverani E., Rico M.C., Tsygankov A.Y., Kilpatrick L.E., and Kunapuli S.P. P2Y12 receptor modulates sepsis-induced inflammation. Arterioscler Thromb Vasc Biol 2016; 36: 961-71
Liverani E., Tsygankov A.Y., Kilpatrick L.E., and Kunapuli S.P. The role of P2Y12 receptor and activated platelets during inflammation. Curr Drug Target 2014; 15: 720-8
Liverani E., Rico M.C., Yaratha L., Tsygankov A.Y., Kilpatrick L.E., and Kunapuli S.P. LPS-induced systemic inflammation is more severe in P2Y12 null mice. J Leuko Biol 2014; 95: 313-23
Liverani E., Rico M.C., Garcia A.E. Kilpatrick L.E., and Kunapuli S.P. Prasugrel metabolites inhibit neutrophil functions. J Pharmacol Exp Ther 2013; 344: 231-43
Liverani E., Banerjee S., Roberts W., Naseem K.M., and Perretti M. Prednisolone exerts exquisite inhibitory properties on platelets functions. Biochem pharmacol 2012 15:1364-73