Kristine Steffen, PharmD, PhD

222F Sudro Hall 

Office Phone 701.231.5177
Lab Phone 701.231.6303 
Fax 701.231.8333


1996-2000  BS, Pharmaceutical Sciences,North Dakota State University
2000-2002  PharmD, Pharmacy Practice, North Dakota State University
2002-2007  PhD, Pharmaceutical Sciences, North Dakota State University
2007           College Teaching Certificate, North Dakota State University


July 2002 - Present  Registered Pharmacist in North Dakota and Minnesota 

Relevant Positions Held

July 2018 - Present
Department of Pharmaceutical Sciences, NDSU College of Health Professions

Aug 2012-June 2018     
Associate Professor
Department of Pharmaceutical Sciences, NDSU College of Health Professions

2016 - Present
Director of Biomedical Research
Neuropsychiatric Research Institute, Fargo, ND

May 2009-Present     
Research Scientist
Neuropsychiatric Research Institute, Fargo, ND 

Dec 2007-May 2009 
NRSA F32 Postdoctoral Fellowship sponsored by NIDDK, 1F32DK072895-01A1
Sponsoring Institution: Neuropsychiatric Research Institute, Fargo, ND
Dec 2002-Dec 2007 
Staff Pharmacist
MeritCare Hospital Pharmacy, Fargo, ND

Professional Memberships

American Society of Metabolic and Bariatric Surgery (ASMBS), 2009-Present
 - Program Planning Committee, Behavioral Health, ASMBS
 - Multidisciplinary Subcommittee Chair of the Integrated Health Section, ASMBS
 - Member of Integrated Health Committee, ASMBS

The Obesity Society (TOS), 2004-Present  

Current Teaching

PSCI 470/670  Pharmacokinetics

Grant Support as PI or Co-PI 

1R01AA022336 and 3R01AA022336-01A1S1
Agency:  National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research:  Alcohol-Related Impairment and Reinforcement after Gastric Bypass Surgery
Role:  Principal Investigator (Co-Principal Investigator - Scott Engel, PhD)
Dates of Award: September 2014 – 2019
Also includes Supplemental Award
Total parent grant amount: $1,953,221; Supplement: $21,024 

1R01DK112585 and 3R01DK112585-01S1
Agency: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research: Mechanisms that Predict Weight Trajectory after Bariatric Surgery: The Interactive Roles of Behavior and Biology
Role: Principal Investigator (Co-Principal Investigator – Leslie Heinberg, PhD)
Dates of Award: September 2016-2021
Total parent grant amount: $3,711,271; Supplement: $838,139

Shire Pharmaceuticals – Investigator Initiated Study
Agency: Shire Pharmaceuticals
Research: A Pharmacokinetic Comparison of Vyvanse® in Patients after Roux-en-Y Gastric Bypass Versus Nonsurgical Controls
Role: Principal Investigator
Co-Investigators: Mitchell J, Roerig J, Orcutt M.
Amount: $302,727

NDSU/Sanford Seed Money Grant
Research: The Effect of Nutrient Intake and Probiotic Administration on Weight and Glucoregulation Following Bariatric Surgery: A Combined Human and Murine Approach
Role: Co-Principal Investigator
Investigators: Steffen, K and Brooks A. (Co-Principal Investigators), Dorsam G (Co-Investigator).
Amount: $87,000

Center of Biomedical Research Excellence (COBRE) Center for Protease Research (CPR) Pilot Project Competition – 2017
Research: Mechanisms Responsible for Weight Loss and Regain Following Roux-en-Y Gastric Bypass: A Translational Study Focused on the Gut Microbiome
Role: Principal Investigator
Investigators: Steffen K (Principal Investigator) and Brooks A (Co-investigator)
Amount: $50,000

Recent Selected Publications

King WC, Chen JY, Belle SH, Courcoulas AP, Dakin GF, Flum DR, Hinojosa MW, Kalarchian MA, Mitchell JE, Pories WJ, Spaniolas K, Wolfe BM, Yanovski SZ, Engel SG, Steffen KJ (2017). Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis. doi:10.1016/j.soard.2017.04.003 

King WC, Chen JY, Courcoulas AP, Dakin GF, Engel SG, Flum DR, Hinojosa MW, Kalarchian MA, Mattar SG, Mitchell JE, Pomp A, Pories WJ, Steffen KJ, White GE, Wolfe BM, Yanovski SZ. (2017). Alcohol and other substance use after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis. doi:10.1016/j.soard.2017.03.021 

Fouladi F, Steffen KJ, Mallik S. (2017). Enzyme-Responsive Liposomes for the Delivery of Anticancer Drugs. Bioconjug Chem, 28(4), 857-868. doi:10.1021/acs.bioconjchem.6b00736.

Steffen KJ, King WC, White GE, Subak LL, Mitchell JE, Courcoulas AP, Flum DR, Strain G, Sarwer DB, Kolotkin RL, Pories W, Huang AJ. (2016). Sexual functioning of men and women with severe obesity before bariatric surgery. Surg Obes Relat Dis. doi:10.1016/j.soard.2016.09.022

Fouladi F, Mitchell JE, Wonderlich JA, Steffen KJ. (2016). The Contributing Role of Bile Acids to Metabolic Improvements After Obesity and Metabolic Surgery. Obes Surg, 26(10), 2492-2502. doi:10.1007/s11695-016 2272-3

Fouladi, F, Mitchell, JE, Crosby, RD, Engel, SG, Crow, S, Hill, L, LeGrange, D, Powers, P, Steffen, KJ (2015). Prevalence of Alcohol and Other Substance Use in Patients with Eating Disorders. Eur Eat Disord Rev, 23(6), 531-536. doi:10.1002/erv.2410

Steffen KJ, Wonderlich JA, Erickson AL, Strawsell H, Mitchell JE, Crosby RD. (2015). Comparison of Warfarin Dosages and International Normalized Ratios Before and After Roux-en-Y Gastric Bypass Surgery. Pharmacotherapy, 35(9), 876-880. doi:10.1002/phar.1632

Steffen KJ, Engel SG, Wonderlich JA, Pollert GA, Sondag C. (2015). Alcohol and Other Addictive Disorders Following Bariatric Surgery: Prevalence, Risk Factors and Possible Etiologies. Eur Eat Disord Rev, 23(6), 442-450. doi:10.1002/erv.2399

Steffen KJ, Engel SG, Pollert GA, Li C, Mitchell JE. (2013). Blood alcohol concentrations rise rapidly and dramatically after Roux-en-Y gastric bypass. Surg Obes Relat Dis, 9(3), 470-473. doi:10.1016/j.soard.2013.02.002

King, WC. Chen, JY, Mitchell, JE, Kalarchian, MA, Steffen, KJ, Engel, SG, Courcoulas, AP, Pories, WJ, Yanovski, SZ (2012). Prevalence of alcohol use disorders before and after bariatric surgery. JAMA, 307(23), 2516-2525. doi:10.1001/jama.2012.6147





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