Sijo Mathew, PhD

Assistant Professor
6B1 Sudro Hall

Sijo Mathew CV


PhD (Biotechnology) 2006
Department of Protein Chemistry and Technology
Central Food Technological Research Institute, Mysore, India  

MS 2000 
University of Agricultural Sciences 
GKVK, Bangalore, India  

BS 1998 
Kerala Agricultural University
Trissur, India 


Research Interests

  • Role of integrin ß1, Talin, and Kindlin in pancreatic cancer progression and desmoplasia.
  • Cell motility and Cytoskeleton Dynamics of epithelial cells in cancer metastasis.
  • Integrin ß1 in acute kidney Injury and recovery.
  • Importance of kindlin isoforms in chronic kidney injury.
  • Cell matrix interactions in growth factor mediated cell signaling in fibrosis. 
  • Importance of integrin homodimerization and its critical role in pancreatic cancer cell functions.
  • Define the structure-function relationship of trans-membrane domain of integrin subunits with its adaptor proteins/growth factor receptors.
  • Elucidate the role of membrane phospholipids in modulating these protein-protein interactions.
  • Evaluate small molecule inhibitor binding with membrane proteins using biophysical methods and their physiological importance using functional assays.

Academic and Professional Appointments

Assistant Professor (Tenure-Track),Department of Pharmaceutical Sciences, School of Pharmacy, North Dakota State University, Fargo, ND, USA (2018-present)

Research Assistant Professor, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA (2012-2018) 

Research Fellow, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA (2008-2012)

Postdoctoral Trainee, Department of Physiology, Univ. of Tennessee Health Science Center, Memphis, TN, USA (2006-2008)


  1. Sijo Mathew  et al., Talin regulates integrin β1 dependent and independent cell functions in ureteric bud development Development 144 (22):4148-4158, 2017.
  2. Lu, Z*., Mathew Sijo* et al., Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function. eLife 2016;5:e18633

*Authors contributed equally

  1. Elias BC*, Mathew S*,, The integrin beta 1 subunit regulates paracellular permeability of kidney proximal tubule cells. J Biol Chem. 2014 Feb 7.PM ID 24509849 2014

*Authors contributed equally

  1. Mathew Sijo, β1 Integrin NPxY Motifs Regulate Kidney Collecting Duct Development and Maintenance by Induced-Fit Interactions with Cytosolic Proteins.Mol Cell Biol. 32(20):4080-91PMID:22869523 2012
  2. Mathew Sijo, Role of integrins in kidney development. Pediatric Nephrology 2012. 27:891-900. PMID:21603909. 2012
  3. Mathew S,, Effect of Zinc Salts on the Structure and Function of Actomyosin From Pelagic Fish. Process Biochemistry. 2009.44:7;704-709   doi:10.1016/j.procbio.2009.02.018 2009
  4. Mathew S,, Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration. J Biol Chem. 2008;283:22709-722. PMID:18482983   2008
  5. Mathew S and Prakash V.  Changes in structural and Functional Attributes of Fish Mince Proteins in Presence of Co-solvent  During Frozen Storage. International Journal of Food Properties. 2007;10 (1) :47–59.  DOI: 10.1080/10942910600684252 2007
  6. Mathew S and Prakash V.  Effect of calcium salts on the properties of proteins from Oil sardine (Sardinella longiceps) during frozen storage. J Food Sci.  2006;71(4):E178 -83. DOI 10.1111/j.1750-3841.2006.00025 2006
  7. Mathew S  and Prakash V. Polyhydric Alcohols Mediated Inhibition of Calcium Activated Adenosine Triphosphatase Activity of Fish Skeletal Muscle Actomyosin. International Journal of Food Properties. 2005;8(2):255-65. DOI: 10.1081/JFP-200060226 2005
  8. Mathew S, Karthikeyan M, Shamasundar BA.  Effect of water washing of shark (Scoliodon laticaudus) meat on the properties of proteins with special reference to gelation.  Nahrung. 2002;46(2):78-82. PMID:12017996. 2002
  9. Mathew S and Shamasundar BA.  Effect of ice storage on the functional properties of proteins from shark (Scoliodon laticaudus) meat. Nahrung. 2002;46:220-6. PMID:12224414. 2002.
  10. Paul J. Barrett, Jiang Chen, Min-Kyu Cho, Ji-Hun Kim, Zhenwei Lu, Sijo Mathew, Dungeng P, Yuanli Song, Wade D. Van Horn, Tiandi Zhuang, and Charles R. Sanders. The Renaissance of Protein NMR.Biochemistry. 2013 Feb 26;52(8):1303-20. PMID:23368985. 2013
  11. Lu, Zhenwei; Van Horn, W; Chen, Jiang; Mathew, Sijo; Zent, Roy; Sanders, Charles (2012). Bicelles at Low Concentration.  Mol Pharm. 2012 Apr 2;9(4):752-61. PMID: 22221179 2012
  12. Borza CM, Chen X, Mathew S, Mont S, Sanders CR, Zent R, Pozzi A. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. J Biol Chem. 2010. 285(51):40114-24. PMID: 20940300 2010
  13. Tomar A, George SP, Mathew S, Khurana S. Differential effects of lysophosphatidic acid and phosphatidylinositol 4,5-bisphosphate on actin dynamics by direct association with the actin-binding protein villin. J Biol Chem. 2009;284:35278–82PMID: 19808673  2009
  14. Khurana S, Tomar A, George SP, Wang Y, Siddiqui MR, Guo H, Tigyi G, Mathew S. (2008). Autotaxin and Lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp Cell Res.  2008;314:530-42.  PMID:18054784. 2008
  15. George SP, Wang Y, Mathew S, Srinivasan K, Khurana S.  Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders.J Biol Chem. 2007;282:26528–41.  PMID:17606613. 2007
  16. Karthikeyan M, Mathew S, Shamasundar BA, Prakash V.  Fractionation and properties of sarcoplasmic proteins from oil sardine (Sardinella longiceps): Influence on the thermal gelatin behavior of washed meat.   J Food Sci.  2006;69(3):FEP 79-84. DOI 10.1111/j.1365-2621.2004.tb13367 2006
  17. Karthikeyan M, Shamasundar BA, Mathew S, Ramesh Kumar P, Prakash V.  Physico-chemical and functional properties of proteins from pelagic fatty fish (Sardinella longiceps) as a function of water washing. International Journal of Food Properties.  2004;7(3):353-65. DOI: 10.1081/JFP-200032913 2004
  18. Venugopal V, Kakatkar A, Bongirwar DR, Karthikeyan M, MathewS, Shamasundar BA.  (2002). Gelation of shark meat under mild acidic conditions: Physicochemical and rheological characterization of the gel. J Food Sci.  67(7):2681-6. DOI 10.1111/j.1365-2621.2002.tb08798. 2002


  1. Sijo Mathew and V. Prakash. A process for inhibiting the adenosinetriphosphatase (ATPase) activity of fish actomyosin using heavy metals.  Patent No.517/DEL/2004; C07K9/00; C12N9/99
  2. Sijo Mathew and V. Prakash. A process for inhibiting the adenosinetriphosphatase (ATPase) activity of fish actomyosin patent No. 550/DEL/2004; C07H21/04; C12N9/10




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