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School of Pharmacy


Steven (Yue) Qian, Ph.D.

219A Sudro Hall 
Office Phone: 701.231.8511
Lab Phone: 701.231.8517 
Fax: 701.231.8333

Steven Qian CV


1999-2004   Post-doctoral in Free Radical Biology and Medicine, Lab. 
                    Pharmacology and Chemistry National Institute of Environmental 
                    Health Sciences (NIEHS/NIH), Research Triangle Park, NC.
1994-1999   Ph.D. in Free Radical/Radiation Biology, College of Medicine, 
                    The University of Iowa, Iowa City, IA. 

Grants and Fellowships

2019-2021 North Dakota Corn Utilization Council, SY Qian & SB Zhong (PIs), “Genetic Engineering of Corn to Produce DGLA-Enriched Oil for Cancer Therapy”

2019-2020 North Dakota, Venture Grant Phase II, SY Qian (PI), “Development new cancer therapeutic drugs”

2019-2020 North Dakota Soybean Council, SY Qian & SB Zhong (PIs), “Genetic Engineering of Soybean for Production  of DGLA-Enriched Oil”

2016-2020 NIH/NIC (1R15CA195499-A1) SY Qian (PI), “New Paradigm of Targeting COX-Catalyzed Free Radical Peroxidation in Colon Cancer”

2016-2021 NIH/NIGMS (1P20 GM109024-01A1) Malik (PI), “Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer”

2016-2017 NDSU-Sanford Health Collaborative Research Seed Grant Program 2016 SY Qian (PI), “Downregulation of D5D to exploit anti-cancer effect of ω-6 diet supplementation for colon cancer treatment”

2014-2019 Investigator (PI: Steffen Kristine J) NIAAA, NIH (1R01AA022336), “Alcohol-Related Impairment and Reinforcement After Gastric Bypass Surgery”

2017-2018 North Dakota, Venture Grant Phase I (17-02-G-163) SY Qian (PI), “Discovery and development new cancer therapeutic drugs via inhibiting D5D and targeting over-expressed COX-2”

2016-2018 NDSU-Sanford Health Collaborative Research Seed Grant Program 2016, SY Qian (PI), “Downregulation of D5D to exploit anti-cancer effect of ω-6 diet supplementation for colon cancer treatment”

2017-2018 NDSU RCA Seed Grant, Changhui Yan (PI), “Development of a Computer-Assisted Drug Design Platform for Cancer Treatment” Role: Co-PI

2014-2016 Investigator (PI: Paul Schwarz) USDA-USWBSI-FY14-SC-013, “Malting Barley Deoxynivalenol Diagnositc Services”

2012-2015 PI. USDA-USWBS- FY12-QI-006, “PH/GBA3-Dependent Stability of D3G's Glycosidic Bond and the Potential Risk to Human Health”

2012-2015 Investigator (PI: Paul Schwarz) USDA-USWBSI-FY12, “Malting Barley Deoxynivalenol Diagnositc Services”

2009-2014 PI, National Cancer Institute, NCI (R15CA140833), “Refinement of LC/ESR/MS for Studying Lipid Free Radicals in Colon Cancer Growth”

2008-2012 Pilot Project P.I. NDSU, COBRE and NCRR, NIH (P20 RR015566), “New strategies for targeting protease in disease”

2008-2009 P.I. NDSU, INBRE, “Identification of Lipid-Derived Radicals Involved in Liver Proteasome Dysfunction in Ethanol-Fed Rats”

2006-2010 P.I., National Cancer Institute, NIEHS (K22ES-012978), “Endogenous Radicals, Hepatic Lipid peroxidation, and ALD”

2005-2007 P.I., ND EPScoR and NDSU/College of Pharmacy start-up fund

1999-2004 IRTA Research Fellowship, NIEHS.


Professional Experience

2019: Professor, Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, ND

2016-date: Director/Co-Director of Animal Core Facility of COBRE Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer, School of Pharmacy, North Dakota State University, Fargo, ND

2012-2018: Associate Professor, Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, ND

2006-date: Joint Faculty and Associate Professor, Cellular and Molecular Biology Program (CMB), North Dakota State University, Fargo, ND.

2008-date: Joint Faculty Member, Investigator, and Associate Professor, Center for Protease Research, North Dakota State University, Fargo, ND.

2005-2012: Assistant Professor, Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, ND.

2004-2007: Guest Researcher/Special Volunteer, Lab. Pharmacology and Chemistry, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC NIEHS, NIH

2004-2005: Research Assistant Professor, Division of Drug Delivery and Disposition, School of Pharmacy, The University of North Carolina at Chapel Hill, NC.

1999-2004: IRTA/Visiting Fellow, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.

1994-1999: Graduate Research Assistant, Free Radical and Radiation Biology Program, College of Medicine, The University of Iowa, Iowa City, IA.

Research Interests 

  • Oxidative stress and toxicology/xenobiotic disposition leading to pathogenesis in disease processes, such as ALD, DILI, neurological, cardiovascular diseases, and cancer.
  • Iron and oxygen chemistry as the initiation of free radical biological reaction 
  • Free radical chemistry and biology as the related human health issues 
  • COX-2 biology and the catalyzed PUFA free radical peroxidation in cancers, as well as in other human health problems  


2007-2019   Pharmacodynamics (PSCI 411/611), School of Pharmacy, NDSU, Fargo ND
2009-2014   Pharmacokinetics (PSCI 470/670), School of Pharmacy, NDSU, Fargo ND
2010-2015   Cancer Cell Biology (PSCI 796), School of Pharmacy, NDSU, Fargo ND
2010-2011   Individual Study (PSCI 494), School of Pharmacy, NDSU, Fargo ND

Professional Honors

2019 Section Chair and Invited Speaker for 2nd Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications, Columbus OH, USA    
2018 Head of Oversea Delegation Award/Honor, Co-Chairman of International Scientific Committee, and Vice chairman of Organizing Committee, the 4th Global Chinese Symposium & The 8th Symposium for Cross-straits, Hong Kong and Macao on Free Radical Biology and Medicine, Sept 2018, Macao
2018 Invited Grant Reviewer, Canada Foundation for Innovation
2017 Council member, Society of FRBM 
2017 Chair and Keynote Speaker, 2017-World Congress on Cancer/Infectious Diseases 
2017 International Advisory Committee, The 8th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia) & The 14th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM) Xian, China
2016 Editorial Board Member, Annals of Pharmacology & Pharmaceutics
2016 Editorial Board Member, Cancer Prevention: Current Research Journal
2016 Editorial Board, Remedy Publications/Pharmacology
2016 Editorial Board, Madridge J. Novel Drug Research
2015 Reviewer of Bioinformatics Seed Grants, NDSU
2015 Reviewer of Research and Development Program-Pfunds, Louisiana Board of Regents
2015 Chair of Panel E2 on BIT’s 5th Annual World Congress of Molecular & Cell Biology. Nanjing, PR China April 2015.
2014 Elected President, International Chinese Society on Research of Free Radical Biology in Medicine
2014 Editorial Board, Free Radical Research
2014 SFRBM Junior Award Committee, Internal Marketing Committee
2014 SFRBM Recruitment Committee, Junior Award Committee
2014 Section Chair, 21st Annual Meeting of SFRBM
2014 International Scientific Executive Committee of The 8th Pong Ding Yuen International Symposium on Traditional Chinese Medicine cum, The 2nd International Chinese Symposium on Free Radical
2013    Dean’s Award for Excellence in Service, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University
2013    SFRBM Recruitment Committee
2012    Dean’s Award for Excellence in Research, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University
2012    Invited Reviewer, NCI Research Grand Study Section, NIH
2012   NDSU Provost Travel and Research Fund
2011    SFRBM Junior Award Committee
2011    Young Investigator Award Committee, 18th SFRBM
2010   Invited Research Grant Reviewer, Florida Department of Health, James/Esther King Biomedical Research Program and Bankhead-Coley Cancer Research Program
2010    Young Investigator Award Committee of 17th SFRBM
2009   NDSU Professional Development Grant
2009   Young Investigator Award Committee, 16th SFRBM
2008   Outstanding Mentor Certificate, NDSU 2008 Summer Undergraduate Research STEM Program 
2008   NDSU Professional Development Grant
2008    Young Investigator Award Committee, 15th SFRBM
2007   NDSU Professional Development Grant
2007    Young Investigator Award Committee, 14th SFRBM
2006    Young Investigator Award Committee, 13th SFRBM
2006   NDSU Professional Development Grant
2006   Section Chair, 13th Annual Meeting of SFRBM
2004   NIEHS nominee for Burroughs Wellcome Fund 
2003   Research Excellence Award (FARE), National Institutes of Health
2002   Young Investigator Award, International Symposium of EPR Spin Trapping
2001   Young Investigator Award, Free Radical Biology & Medicine (Oxygen) Society
1998   Travel Award, American Society for Photobiology
1997   Travel Awards, University of Iowa 
1997   Travel Award, American Society for Photobiology
1996   Young Investigator Awards, Free Radical Biology & Medicine (Oxygen) Society
1996   Travel Awards, University of Iowa 
1996   Travel Award, Radiation Research Society 

Awards for Students and Advisees:

2008 Best Research Presentation Award
Oluseyi Amele (Summer Intern Undergraduate Student)
NDSU 2008 Summer Undergraduate Research STEM Program.

2009 PRACS Institute/James D. Carlson Graduate Student Research Scholarship
Preeti Purwaha (Ph.D. Student from 2007-2011)
College of Pharmacy, Nursing, and Allied Sciences, NDSU

2011 PRACS Institute/James D. Carlson Pharmacy Student Research Scholarship
Jingyang Xiao (Pharm. D. student, conducted research in the lab from 2010-2011)
College of Pharmacy, Nursing, and Allied Sciences, NDSU.

2013 The 1st Place Oral Presentation Award
Shechinah Tinsley (Summer Intern Undergraduate Student)
NDSU 2013 Summer Undergraduate Research STEM Program.

2013 The 1st place award of poster presentation in National NOBCChE conference in Indianapolis, IN
Shechinah Tinsley (Summer Intern Undergraduate Student)

2014 Darryle and Clare Schoepp Graduate Research Scholarship, Y Xu (graduate student)

Professional Associations

Society for Free Radical Biology & Medicine (SFRBM)
American Association for Cancer Research (AACR)


Wood I, Trostchansky A, Xu Y, Qian SY, Radi R, Rubbo H.  Free radical-dependent inhibition of prostaglandin endoperoxide H Synthase-2 by nitro-arachidonic acid. Free Radic Biol Med. (2019) In Press. 

Gao YF, Zhou S, Pang LZ, Yang JC, Li HJ, Huo XW, Qian SY. Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer. Free Radic Research (2019) 18: 324-334. 

Gao YF, Zhou S, Xu Y, Sheng S, Qian SY, Huo XW. Nitric oxide synthase inhibitors 1400W and L-NIO inhibit angiogenesis pathway of colorectal cancer. Nitric Oxide (2019) 83: 33-39. 

Xu Y, Pang LZ, Wang HZ, Xu CC, Shah HS, Guo PX, Shu D, Qian SY. Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression. Redox Biology (2019) 21: 101085. 

Yang XY, Xu Y, Gao D, Yang L, Qian SY. Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA, Redox Biology (2019) 20: 236-246. 

Xu Y, Yang XY, Wang T, Gao D, Yang L, Miskimins K, Qian SY. Dihomo-γ-Linolenic Acid Inhibits Xenograft Tumor Growth in Mice Bearing shRNA-Transfected HCA-7 Colony 29 Cells Targeting Delta-5-Desaturas. BMC Cancer (2018) 18:1268 

Gao YF, Wang J, Zhou Y, Sheng S, SY Qian and Huo XW. Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer. Sci Reports (2018) 8: 2732. 

Xu Y, Yang XY, Wang T, Liu GD, He YY, Miskimins K, Qian SY. Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism. BMC Cancer (2018) 18: 330.79.  

Sample A, Zhao BZ, Wu CL, Qian SY, Shi XL, Aplin A, He YY. The autophagy receptor p62 is up-regulated by UVA in melanocytes and in melanoma (Special Issue Research Article) Photochemistry and Photobiology (2018) 94: 432-437.

Qi J, Sun LQ, Qian SY, Yu BY. A novel multi-hyphenated analytical method to simultaneously determine xanthine oxidase inhibitors and superoxide anion scavengers in natural products. Analytica Chimica Acta (2017) 984: 124-133

Pan YX, Neupane S, Farmakes J, BridgesM, Froberg J, Rao JJ, Qian SY, Liu GD, Choi YK, Yang ZY. Probing the structural basis and adsorption mechanism of an enzyme on nano-sized protein carriers. Nanoscale (2017) 9: 3512-3523. 

Yang X, Xu Y, Wang T, Shu D, Guo PX, Miskimins K, Qian SY. Inhibition of cancermigration and invasion by knocking

Z Zhao, L Reinstatler, Z Klaassen, Y Xu, X Y, R Madi, M Terris, SY Qian, U Kelavkar, KA. Moses. The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. PLOS ONE, 2016 in press.

S Neupane, Y Pan, S Takalkar, K Bentz, J Farmakes Y Xu, B Chen, G Liu, S Y Qian, Z Yang. Probing the Aggregation Mechanism of Gold Nanoparticles Triggered by a Globular Protein. Submitted to The Journal of Physical Chemistry, 2016 in press.

M Sun, Q Zhang, X Yang, SY Qian, B Guo. Vitamin D Enhances the Efficacy of Irinotecan through miR-627–Mediated Inhibition of Intratumoral Drug Metabolism. Molecular Cancer Therapeutics (2016) 15: 2086-2095.

X Yang, Y Xu, A Brooks, B Guo, KWMiskimins, SY Qian. Knockdowndelta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs. FRBM (2016) 97: 342-350

Y Xu, XY Yang, PJ Zhao, ZY Yang, CH Yan, B Guo, SY Qian. Knockdown of delta-5-desaturase promotes the anti-cancer activity of DGLA and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2. FRBM (2016) 96: 67-77.

NB Stebbins, LR Howard, RL Prior, C Brownmiller, R Liyanage, JO Lay, X Yang, SY Qian. Ascorbic acid-catalyzed degradation of cyanidin-3-glucoside: Proposed mechanism and identification of a novel hydroxylated product J. Berry Research (2016) 6: 175-187.

T Anajafi, MD Scott, S You, X Yang, Y Choi, SY Qian, S Mallik. Acridine Orange Conjugated Polymersomes for Simultaneous Nuclear Delivery of Gemcitabine and Doxorubicin to Pancreatic Cancer Cells, Bioconjug Chem. (2016) 27: 762-71.

S Alwarsh, Y Xu, SY Qian, MC McIntosh Radical [1,3] Rearrangements of Breslow Intermediates. Angew Chem Int Ed Engl. (2016) 55: 355-358.

SA Brigandi, H Shao, SY Qian, Y Shen, BL Wu, JX Kang. Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. Int J Mol Sci. (2015) 16:10061-76.

H Zhao, G Qi, Y Han, X Shen, F Yao, C Xuan, Y Gu, SY Qian, Q Zeng, ST OʼRourke, CW Sun. 20-Hydroxyeicosatetraenoic Acid Is a Key Mediator of Angiotensin II-induced Apoptosis in Cardiac Myocytes. J Cardiovasc Pharmacol. (2015) 66: 86-95.

S Ding, SY Qian, Y Zhang, W Wu, G Lu, Y Lu, X Feng, L Li, PP Shen Establishment of immunoassay for detecting HPV16 E6 and E7 RNA. Sci Rep. (2015) 5: 13686.

Xu Y, Qi J, Yang X, Wu E, Qian SY. Free radical derivatives formed from COX-catalyzed DGLA peroxidation can attenuate colon cancer cell growth and enhance 5-FU’s cytotoxicity. Redox Biology. 2: 610-618; 2014.

Xu Y, Qian SY. Anti-cancer activity and mechanism from ω-6 polyunsaturated fatty acids. Biomed J. 37: 112-119; 2014.

Zhou S, Wang F, Zhang Y, Johnson MR, Qian SY, Wu M, Wu E. Salinomycin Suppresses PDGFRβ, MYC, and Notch Signaling in Human Medulloblastoma. Austin J Pharmacol Ther. 2: 1-7; 2014.

Schwarz PB, Qian SY, Xu Y, Barra JM, Horsleya RD, Gillespie J. Occurrence of Deoxynivalenol-3-Glucoside on Barley from the Upper Midwestern USA. J. Am. Soc. Brew. Chem. 72: 208-213; 2014.

Malik R, Wagh A, Qian S, Law B. A single-layer peptide nanofiber for enhancing the cytotoxicity of trastuzumab (anti-HER). J. Nanoparticle Research. 15: 1682-1699, 2013. 

Pender-Cudlip MC, Krag KJ, Martini D, Yu J, Guidi A, Skinner SS, Zhang Y, Qu X, He C, Xu Y, Qian SY, Kang JX. Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue. Cancer Sci. 104: 760-764; 2013. 

Wagh, A., Jyoti, R., Mallik, S., Qian, S., Leclerc, E., and Law, B. Polymeric Nanoparticles with Sequential and Multiple FRET Cascade Mechanisms for Multicolor and Multiplexed Imaging, Small. 9: 2129-2139; 2013. 

Gu Y, Xu Y, Law B, and Qian SY. The First Characterization of Free Radicals Formed From Cellular COX-Catalyzed Peroxidation, Free Radic Biol Med. 57: 49-60; 2013. 

Wagh A, Singh J, Qian S, Law B. A short circulating peptide nanofiber as a carrier for tumoral delivery. Nanomedicine: Nanotechnology, Biology, and Medicine. 2012, In press. 

Wagh A, Qian SY, Law B. Development of biocompatible polymeric nanoparticles for in vivo NIR and FRET imaging. Bioconjugate Chem. In press; 2012.

Qian SY, Xu Y, Gu Y. Combination of Spin-Trapping, LC/ESR and LC/MS Technique in Characterization of PUFA-Derived Free Radials in Lipid Peroxidation. Acta Biophysica Sinica28: 355-372; 2012

Senay Simsek, Kimberly Burgess, Kristin L. Whitney, Yan Gu, Steven Y. Qian. Analysis of Deoxynivalenol and Deoxynivalenol-3-glucoside in Wheat. Food Control. In press, 2012.

Purwaha P, Gu Y, Kelavkar U, Kang JX, Law B, Wu E, Qian SY. LC/ESR/MS study of pH-dependent radical generation from 15-LOX catalyzed DPA peroxidation. Free Radic Biol Med. 51: 1461-1470; 2011. 

Malik R, Qian SY, Law B. Design and synthesis of a near-infrared fluorescent nanofiber precursor for detecting of cell-secreted urokinase activity. Analytical Biochem. 412: 26-33; 2011. 

Nyren-Erickson EK, Haldar MK, Gu Y, Qian SY, Friesner DL, Mallik S. Fluorescent liposomes for differential interactions with glycosaminoglycans. Anal. Chem. 83: 5989-5995; 2011. 

Wang F, Bhat K, Doucette M, Zhou S, Gu Y, Law B, Liu X, Wong ET, Kang JX, Hsieh TC, Qian SY, Wu E. Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. Curr. Mol. Med. 11:1-9; 2011. 

Zhang W, Phillips K, Wielgus AR, Liu J, Albertini A, Zucca FA, Faust R, Qian SY, Miller DS, Chignell CF, Wilson B, Jackson-Lewis V, Przedborski S, Joset D, Loike J, Hong JS, Sulzer D, Zecca L. Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease. Neurotox Res. 19: 62-72; 2011. 

Zou Y, Chang S, Gu Y, Qian SY. Antioxidant activity and phenolic compositions of the extract of lentils (Lens culinaris var. Morton) and its fractions. J. Agr Food Chem. 59: 2268-2276; 2011. 

Xiao Y, Gu Y, Purwaha P, Ni K, Law B, Mallik S, Qian SY. Characterization of free radicals formed from COX-catalyzed DGLA peroxidation. Free Radic Biol Med. 50: 1163-1170; 2011. 

Berg AK, Yu Q, Haldar MK, Qian SY, Srivastava DK. Solvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase. B.B.A. 1804: 704-713; 2010. 

Subramaniam R, Xiao Y, Li Y, Qian SY, Sun W, Mallik S. Light-mediated and H-bond facilitated liposomal release: The role of lipid head groups in release efficiency. Tetrahedron Letters, 51: 529-532; 2010. 

Zhang Q, Yao F, O’Rourke S, Qian SY, Sun C. Angiotensin II enhances GABAB receptor-mediated responses and expression in nucleus tractus solitarii of rats. Am J Physiol Heart Circ Physiol. 297: H1837-H1844; 2009. 

Yu Q, Xiao Y, Ni K, Qian SY.  Identification and characterization of carbon-centered free radicals formed from lipoxygenase-catalyzed lipid peroxidation of DLA. Chinese J. Analytical Chem.  37:1815-1819, 2009.

Yu Q, Purwaha P, Ni K, Sun C, Mallik S, and Qian SY. Characterization of Novel Radicals from COX-Catalyzed Arachidonic Acid Peroxidation. Free Radic Biol Med., 47: 568-576. 2009.

Syn WK, Yang L, Chiang DJ, Qian Y, Jung Y, Karaca1 G, Choi SS, Witek RP, Omenetti A, Pereira TA, Diehl AM. Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. Liver Int. 29: 1262-1272; 2009. 

Shan Z, Yu Q, Guo B, and Qian SY.  A combination study of spin-trapping, LC/ESR and LC/MS on carbon-centred radicals formed from lipoxygenase-catalysed peroxidation of eicosapentaenoic acid. Free Radical Research. 43: 1-15; 2009. DOI:, PMID: 19085251.

Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M, and Hong JS. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem Res. 33: 2044-2053; 2008.  DOI:, PMID: 18368483.

Liu J, Qian SY, Guo Q, Jiang J, Waalkes MP, Mason RP, and Kadiiska MB.  Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studies. Free Radic Biol Med. 45: 475-481; 2008. PMID: 18501199, DOI:

Yu Q, Shan Z, Ni K, and Qian SY. LC/ESR/MS Study of Spin Trapped Carbon-Centered Radicals Formed From In Vitro Lipoxygenase-Catalyzed Peroxidation of -Linolenic Acid.  Free Radical Research. 42: 442-455; 2008. DOI: PMID: 18484409;

Yang Z, Yang S, Hong JS, Qian SY, Kadiiska MB, Tennant RW, Waalkes MP, and Liu J. Cadmium-induced toxicity in rat primary mid-brain neuro-glia cultures: role of oxidative stress from microglia.  Toxicol. Sci.  98: 488-494; 2007. PMID: 17483498, DOI:

Shan X, Chi L, Ke Y, Luo C, Qian S, Gozal D, Liu R. Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage. Neurobiol Dis. 28: 206-215; 2007. PMID: 17719231,  DOI:

Dyers JD, Que (Qian, misspell) SY, VanDerveer D, and Bu XR. Synthesis and structures of new salen complexes with bulky groups. Inorg. Chim. Acta.  359: 197-203; 2006. 

Qian SY, Kadiiska MB, Guo Q, Liu J, and Mason RP.  A novel protocol to identify and quantify all spin trapped free radicals from in vitro/in vivo interaction of HO• and DMSO: LC/ESR, LC/MS, and dual spin-trapping combinations.  Free Radic. Biol. Med. 38: 125-135; 2005. PMID: 15589381, DOI:

Guo Q, Gao G, Qian SY, and Mason RP. Novel identification of a sulfur-centered radical-derived DMPO nitrone adduct formed from the oxidation of dithiothreitol by LC/ELISA, LC/ESI-MS and LC/MS/MS.  Chem. Res. Toxicol.  17: 1481-1490; 2004. PMID: 15540946, DOI:

Colon ML, Qian SY, Vanderveer D, and Bu XR.  Chiral bimetallic complexes from chiral salen metal complexes and mercury (II) halides and acetates.  Inorg. Chim. Acta. 357: 83-88; 2004.

Towner RA, Qian SY, Kadiiska MB, and Mason RP.  In vivo identification of aflatoxin-induced free radical in rat bile.  Free Radic. Biol. Med.  35: 1330-1340; 2003. PMID: 14607532,  DOI:

Qian SY, Guo Q, Mason RP.  Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of ω-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and Tandem MS. Free Radic. Biol. Med. 35: 33-44; 2003. PMID: 12826254, DOI:

Guo Q, Qian SY, and Mason RP.  Separation and identification of DMPO adducts of oxygen-centered radicals formed from organic hydroperoxides by HPLC-ESR, ESI-MS and MS/MS. J. Am. Soc. Mass Spectr.  14: 862-871; 2003. DOI:, PMID: 12892910.

Qian SY, Yue GH, Tomer KB, and Mason RP.  Identification of all classes of spin-trapped carbon-centered radicals in soybean lipoxygenase-dependent lipid peroxidations of ω-6 PURA via LC/ESR, LC/MS and MS/MS.  Free Radic. Biol. Med.  34: 1017-1028; 2003. PMID: 12684086, DOI:

Qian SY, Tomer KB, Yue GH, Guo Q, Kadiiska MB, and Mason RP.  Characterization of the initial carbon-centered pentadienyl radical and subsequent radicals in lipid peroxidation: Identification via LC/ESR and MS.  Free Radic. Biol. Med.  33: 998-1009; 2002. PMID: 12361809, DOI:

Guo Q, Corbett JT, Yue GH, Fann YC, Qian SY, Tomer KB, and Mason RP.  Electron spin resonance investigation of semiquinone radicals formed from the reaction of ubiquinone 0 with human oxyhemoglobin.  J. Biol. Chem.  277: 6104-6110; 2002. PMID: 11748217, DOI:

Qian SY, Chen YR, Deterding LJ, Fann YC, Chignell CF, Tomer KB, and Mason RP.  Identification of protein-derived tyrosyl radical in the reaction of cytochrome c and hydrogen peroxide: characterization by ESR spin-trapping, HPLC and MS. Biochem. J. 363: 281-288; 2002. PMID: 11931655.

Liang S, Derveer DV, Qian SY, Sturgeon B, and Bu XR.  A chiral salen vanadyl complex with two significantly different configurations in solid state: synthesis, characterization, and molecular structure.  Polyhedron.  21: 2021-2025; 2002. 

Wang HP, Qian SY, Schafer FQ, Domann FE, Oberley LW, and Buettner GR.  Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy.  Free Radic. Biol. Med.  30: 825-835; 2001. PMID: 11295525,  DOI:

Qian SY, Wang HP, Schafer FQ, and Buettner GR.  EPR detection of lipid-derived free radicals from PUFAs, LDL, and cell oxidations.  Free Radic. Biol. Med.  29: 568-579; 2000. PMID: 11025200, DIO:

Schafer FQ, Qian SY.; and Buettner GR. Iron and free radical oxidations in cell membranes. cell. Mol. Biol.  46: 657-662; 2000. PMID: 10872752.

Qian SY, and Buettner GR.  Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations.  Free Radic. Biol. Med.  26: 1447-1456; 1999. PMID: 10401608,  DOI:

Liu NF, Chen RX, Zhang LR, and Qian, Y.  Detection of hydroxyl radicals in the oxidation of LDL by ESR spin trapping technique.  Chinese J. Pathophysiology. 10: 631-634; 1994. 

Yan H, Chen HL, Qian Y, and Tang WX.  The first study on 2’,5’-dideoxynucleosidyl radicals formed from the anaerobic photolysis of 2’,5’-dideoxynucleosidylcobalamines by the ESR spin-trapping technique.  J. Inorg. Biochem. 56: 265-271; 1994.

Xu H, Xu Z, Li MX, Li BL, Qian Y, You XZ, Zhu DL, and Yu YP.  Study on basicity of axial ligands effects on monomeric dioxygen adduct of cobalt(II)-schiff base complex by ESR method.  J. Inorg. Chem.  9: 331-335; 1993. 

Xu JH, He JP, and Qian Y.  Photoinduced coupling reaction of benzotriazole with aromatic hydrocarbons sensitized by 9, 10-dicyanoanthracene (DCA) via an electron-transfer mechanism.  J. Chem. Soc., Chem. Comm. 10: 714-715; 1991. 

Fen R, Qian Y, Xu JY, Wang SW, Li HM, and Shi Q.  Therapeutic ultrasound cavitation and its free radical ESR determination.  Acta Acustica.  16: 306-312; 1991. 

Chen HL, Qian Y, Chen GJ, and Tang WX.  Study of coenzyme B12 model compounds: identification of alkyl radicals in RCo(Salen)L solution by spin trapping-ESR techniques.  Chinese Science Bulletin.  36: 42-46; 1991. 

Fen R, Qian Y, Xu JY, Shi Q, Wang SW, and Li HM.  Therapeutic ultrasound cavitation and its free radical ESR determination.  Chinese J. Acoustics.  10: 131-138; 1991. 

Chen HL, Qian Y, Chen GJ, and Tang WX.  Study of coenzyme B12 model compounds: EPR identification of alkyl radicals in RCo(Salen)L solution.  Chinese Science Bulletin. 14: 1070-1073; 1990.

Shi Q, Qian Y, Fen R, Liu H, Xu JY, and Li HM.  Spectrofluorimetry study of free radicals produced by simulated therapeutic ultrasound.  Acta Biophysica Sinica.  6: 485-489; 1990. 

Sun SH, Meng QJ, You XZ, Qian Y, and Bu XR.  Electrochemistry of RCo3(CO)9 and ESR Spectra of RCo3(CO)9•-.  Chinese J. Magnetic Resonance.  6: 137-142; 1989. 

Gan LR, Wu YY, Li H, Hu YF, and Qian Y.  Study on some bis-schiff bases from isophthalic aldehyde and their copper (II) complexes.  J. Inorg. Chem.  5: 81-89; 1989. 

Meng QJ, Bu XR, Sun SH, Qian Y, and You XZ.  ESR studies on iminato-VO(II) complexes.  J. Inorg. Chem.  5: 40-45; 1989. 

Yang SY, Ye F, Qian Y, Gao JY, and Liu YC.  ESR studies of -tocopherol model-chromanoxyl radical.  Acta Biophysica Sinica.  5: 349-353; 1989. 

Qian Y.  Sonochemistry: historical development and modern aspects (Translated Review).  J. Jian Teachers College.  6: 75-88; 1988. 

Li HM, Qian Y, Tang JH, and Fen R.  Preliminary research on cavitation on medical ultrasound.  J. Jian Teachers College. 5: 1-4; 1988. 

Published Book Chapters and Other Research Activity

Xu Y, Wang HZ, Shu D, Gao PX, Qian SY. Specific delivery of siRNA to tumor cells via innovative pRNA nanoparticles: a novel promising cancer treatment strategy. Soft condensed matter on the nanoscale: the WSPC reference on functional nanomaterials, Vol 1: Nanomedicine (Chapter 6) 2019. 

Xu Y, Qian SY. Pulmonary Vasculature Redox Signaling in Health and Disease: Chapter 23-techniques for detecting reactive oxygen species in pulmonary vasculature redox signaling, Springer Nature. Adv Exp Med Biol. Vol: 967, 2017. 

Yu QF, Purwaha P, Ni KY, Qian SY. Identification of a novel spin trapped carbon-centered radical from COX-catalyzed peroxidation of arachidonic acid: LC/ESR and LC/MS study. In: The roles of free radicals in biology and medicine. Ed: Zhao B, Davies M, and Cadeans E. Medimond page: 179-184, 2008.

Student Focused. Land Grant. Research University.

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North Dakota State University
Phone: +1 (701) 231-7456 / Fax: (701) 231-7606
Campus address: Sudro Hall 123
Physical/delivery address: 1401 Albrecht Boulevard, Fargo, ND 58102
Mailing address: NDSU Dept. 2650 / PO Box 6050 / Fargo, ND 58108-6050
Page manager: NDSU School of Pharmacy

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