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Sylvio May, Associate Professor and Chair

Ph.D., Physics, Friedrich-Schiller University , Jena, Germany (1996), Thesis: Elastic properties of mixed and charged amphiphilic membranes

Department of Physics,
North Dakota State University, Dept # 2755,
Fargo ND, 58108-6050, USA
Office: South Engineering 216A
Tel: (701) 231-7048 or 231-8974
Fax: (701) 231-7088
email: sylvio (dot) may (at) ndsu (dot) edu

Research Interests

  • Thermodynamics of lipid membranes and interactions with biopolymers
  • Electrostatics, Poisson-Boltzmann theory, ionic interactions in soft matter systems
  • Modeling the kinetics of liposomal drug delivery

List of Publications

84. Amaia Beloqui Redondo, Inga Jordan, Ibrahim Ziazadeh, Armin Kleibert, Javier B Giorgi, Hans Jakob Woerner, Sylvio May, Zareen Abbas, and Matthew Brown, "Nanoparticle Induced Charge Redistribution of the Air-water Interface", J Phys. Chem. C, DOI: 10.1021/jp511915b (2015)

83. Helen Y Fan, Gaurav Raval, Alireza Shalviri, Sylvio May, Xiao Y Wu, and Heiko Heerklotz, "Coupled Equilibria upon Loading a Self-Associating Drug into Polymeric Nanoparticles", Methods, DOI:10.1016/j.ymeth.2014.12.015 (2015)

82. Kalpa Nagarsekar, Mukul Ashtikar, Jana Thamm, Frank Steiniger, Felix Schacher, Alfred Fahr, and Sylvio May, "Electron Microscopy and Theoretical Modeling of Cochleates", Langmuir, 2014, 30, 13143-13151 (2014)

81. Klemen Bohinc, Juan J. Giner-Casares, and Sylvio May, "Analytic Model for the Dipole Potential of a Lipid Layer ", J. Phys. Chem. B, 118 (27), 7568-7576 (2014)

80. Sylvio May and Klemen Bohinc, "Mean-field electrostatics of stiff rod-like ions", chapter 23 in "Electrostatics of Soft and Disordered Matter", edited by: David Dean , Jure Dobnikar , Ali Naji , and Rudolf Podgornik; Pan Stanford Publishing, pages 335-346 (2014)

79. Daniel Harries, Sylvio May, and Avinoam Ben-Shaul, "Counterion Release in Membrane--Biopolymer Interactions", Soft Matter, 9 (39), 9268 - 9284 (2013)

78. Muyang Wang, Er-Qiang Chen, Shuang Yang, and Sylvio May, "Incorporating Headgroup Structure into the Poisson-Boltzmann Model of Charged Lipid Membranes", J. Chem. Phys. 139, 024703 (2013)

77. Miha Fosnaric, Ales Iglic, Daniel M. Kroll, and Sylvio May, "Monte Carlo simulations of a polymer confined within a fluid vesicle", Soft Matter, 9, 3976 (2013)

76. Stephan Loew, Edgar E Kooijman, and Sylvio May, "Increased pH-sensitivity of protein binding to lipid membranes through the electrostatic-hydrogen bond switch", Chem. Phys. Lipids, 169, 9-18 (2013)

75. Christiane Decker, Harald Schubert, Sylvio May, and Alfred Fahr, "Pharmacokinetics of temoporfin-loaded liposome formulations: Correlation of liposome and temoporfin blood concentration", Journal of Controlled Release, 166, 277-285 (2013)

74. Sylvio May and Alfred Fahr, ''Self-assembled delivery vehicles for poorly water-soluble drugs: Basic theoretical considerations and modeling concepts'', Drug Delivery Strategies for Poorly Water-Soluble Drugs. D.Douroumis and A.Fahr editors. Wiley, Chapter 1, 1-35 (2013)

73. Ahis Shrestha, Klemen Bohinc, and Sylvio May, ''The Immersion Depth of Positively versus Negatively Charged Nanoparticles at the Air-Water Interface: A Poisson-Boltzmann Model'', Langmuir, 28 (40), 14301-7 (2012)

72. Klemen Bohinc, Gerald Brezesinski, and Sylvio May, "Modeling the influence of adsorbed DNA on the lateral pressure and tilt transition of a zwitterionic lipid monolayer'', Phys. Chem. Chem. Phys., 14, 10613-10621 (2012)

71. Christiane Decker, Alfred Fahr, Judith Kuntsche, and Sylvio May, "Selective Partitioning of Cholesterol and a Model Drug into Liposomes of Varying Size", Chem. Phys. Lipids, 165, 520-529 (2012)

70. Klemen Bohinc, Ahis Shrestha, Milan Brumen, and Sylvio May, "The Poisson-Helmholtz-Boltzmann model of the electric double layer: analysis of monovalent ionic mixtures", Phys. Rev. E 85, 031130 (2012)

69. Sylvio May, "Mean-field Continuum Electrostatics of Lipid Membranes", in: Encyclopedia of Surface and Colloid Science. P. Somasundaran editor. Taylor and Francis, Chapter 275, 1-15 (2012)

68. Klemen Bohinc, Ahis Shrestha, and Sylvio May, "The Poisson-Helmholtz-Boltzmann Model", Eur. Phys. J. E, 34, 108 (2011)

67. Sylvio May and Klemen Bohinc, "Attraction between like charged surfaces mediated by uniformly charged spherical colloids in a salt solution", Croat. Chem. Acta, 84 (2), 251-257 (2011)

66. Stephan Loew, Alfred Fahr, and Sylvio May, "Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers", Journal of Drug Delivery, 2011, 376548 (2011)

65. Demmelash H Mengistu, Edgar E Kooijman, and Sylvio May, "Ionization Properties of Mixed Lipid Membranes: A Gouy-Chapman Model of the Electrostatic-Hydrogen Bond Switch", BBA Biomembranes,  1808, 1985-1992 (2011)

64. Klemen Bohinc, Jurij Rescic, Stefano Maset, and Sylvio May, "Debye-Hückel theory for mixtures of rigid rod-like ions and salt", J. Chem. Phys, 134, 074111 (2011)

63. Waipot Ngamsaad, Sylvio May, Alexander J. Wagner, and Wannapong Triampo, "Pinning of Domains for Fluid-Fluid Phase Separation in Lipid Bilayers with Asymmetric Dynamics", Soft Matter, 7 (6), 2848 - 2857(2011)

62. Hossam Hefesha, Sylvio May, Stephan Loew and Alfred Fahr, "Transfer Mechanism of Temoporfin between Liposomal Membranes" Journal of Controlled Release, 150, 279-286  (2011)

61. Demmelash H. Mengistu, Klemen Bohinc, and Sylvio May , "A model for the electrostatic contribution to the pH-dependent nonideal mixing of a binary charged-zwitterionic lipid bilayer", Biophys. Chem., 150, 112-118 (2010)

60. Demmelash H. Mengistu, Klemen Bohinc, and Sylvio May , "Poisson-Boltzmann model in a solvent of interacting Langevin dipoles", EPL (88), 14003 (2009)

59. Demmelash H. Mengistu, Klemen Bohinc, and Sylvio May , "Binding of DNA to Zwitterionic Lipid Layers mediated by Divalent Cations", J. Phys. Chem. B., 113 (36), 12277-12282 (2009)

58. Miha Fosnaric, Ales Iglic, Daniel M. Kroll, and Sylvio May, "Monte Carlo simulations of complex formation between a mixed fluid vesicle and a charged colloid", J. Chem. Phys., 131, 105103  (2009)

57. Klemen Bohinc, Ales Iglic, Stefano Maset, and Sylvio May, "The interaction between charged macroions induced by rod-like ions", IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany, Vol. 25/8 Micro- and Nanosystems in Medicine, Active Implants, Biosensors, pp. 329-331 (2009)

56. Sylvio May, "Trans-monolayer coupling of fluid domains in lipid bilayers", Soft Matter, 5, 3148 - 3156 (2009)

55. Stefano Maset, Jurij Rescic, Sylvio May, Janez Ivan Pavlic, and Klemen Bohinc,  "Attraction between like-charged surfaces induced by orientational ordering of divalent rigid rod-like counterions: theory and simulations", J. Phys. A: Math Theor., 42, 105401 (2009)

54. Stephan Loew, Anne Hinderliter, and Sylvio May, "Stability of protein-decorated mixed lipid membranes: the interplay of lipid-lipid, lipid-protein, and protein-protein interactions", J. Chem. Phys. 130 045102 (2009)

53. Sylvio May, ''Models of Membrane Fusion'', Chapter 12 in: Handbook of Molecular Biophysics. H. Bohr editor. Wiley-VCH, pages 385-414 (2009)

52. Shuang Yang and Sylvio May, "Release of cationic polymer-DNA complexes from the endosome: A theoretical investigation of the proton sponge hypothesis", J. Chem. Phys., 129 185105 (2008)

51. Demmelash H. Mengistu and Sylvio May, "Nonlinear Poisson-Boltzmann model of charged lipid membranes: Accounting for the presence of zwitterionic lipids", J. Chem. Phys. 129, 121105 (2008)

50. Demmelash H. Mengistu and Sylvio May, "Debye-Huckel theory of mixed charged-zwitterionic lipid layers", Eur. Phys. J. E, 26, 251-260 (2008)

49. Assaf Zemel, Avinoam Ben-Shaul, and Sylvio May, "Effect of Amphipathic Peptides on the Spontaneous Curvature and Bending Rigidity of Lipid Membranes", J. Phys. Chem. B, 112; 6988-6996 (2008)

48. Sylvio May, Ales Iglic, Jurij Rescic, Stefano Maset and Klemen Bohinc, "Bridging like-charged macroions through long divalent rod-like ions", J. Phys. Chem. B, 112, 1685-1692 (2008)

47. Andrew Haugen and Sylvio May, "The influence of zwitterionic lipids on the electrostatic adsorption of macroions onto mixed lipid membranes", J.Chem.Phys., 127, 215104 (2007)

46. Alexander J Wagner, Stephan Loew, and Sylvio May, "Influence of Monolayer-Monolayer Coupling on the Phase Behavior of a Fluid Lipid Bilayer", Biophys. J., 93, 4268-4277 (2007)

45. Alexander J. Wagner and Sylvio May, "Electrostatic interactions across a charged lipid bilayer", Eur. Biophys. J., 36 (4-5): 293-303, (2007)

44. Sylvio May and Avinoam Ben-Shaul, "Molecular Packing in Cylindrical Micelles", Chapter 2 in: Giant Micelles: Properties and Applications. R. Zana and E. Kaler editors. CRC Press, Boca Raton, p.41-80, (2007)

43. Miha Fosnaric, Ales Igic and Sylvio May, "Influence of rigid inclusions on the bending elasticity of a lipid membrane", Phys. Rev. E, 74 051503 (2006)

42. Klemen Bohinc, Veronica Kralj-Iglic, Tomas Slivnik, Sylvio May and Ales Iglic, "Spatial distribution of divalent rod-like ions in contact with a charged surface", Electrotechnical Review 73 (2-3) pp. 137-142 (2006)

41. Anne Hinderliter and Sylvio May, "Cooperative adsorption of proteins onto lipid membranes", J.Phys. Cond. Matter, 18, S1257-S1270 (2006)

40. Emmanuel C. Mbamala, Alfred Fahr and Sylvio May, "An electrostatic model for mixed cationic-zwitterionic lipid bilayers", Langmuir, 22 (11), 5129 -5136 (2006)

39. Maria Maddalena Sperotto, Sylvio May and Artur Baumgaertner, "Modeling of Proteins in Membranes", Chem. Phys. Lipids, 141, 2-29 (2006)

38. Klemen Bohinc, Darko Lombardo, Veronika Kralj-Iglic, Miha Fosnaric, Sylvio May, Franjo Pernus, Henry Hagerstrand and Ales Igic, "Shape variation of bilayer membrane daughter vesicles induced by anisotropic membrane inclusions", Cell. Mol. Biol. Lett., 11, 90-101 (2006)

37. Veronica Kralj-Iglic, Blaz Babnik, Dorit R. Gauger, Sylvio May and Ales Iglic, "Quadrupolar ordering of phospholipid molecules in narrow necks of phospholipid vesicles", J. Stat. Phys., 125 (3), pp. 723-748 (2006)

36. Miha Fosnaric, Klemen Bohinc, Dorit R. Gauger, Veronika Kralj-Iglic, Ales Igic and Sylvio May, "The influence of anisotropic membrane inclusions on curvature elastic properties of lipid membranes", J. Chem. Inf. Model., 45 (6), 1652 -1661 (2005)

35. Sylvio May, "Stability of macroion-decorated lipid membranes" , Journal of Physics: Condensed Matter, 17, R833-R850 (2005)

34. Alfred Fahr, Peter van Hoogevest, Sylvio May, Nill Bergstrand and Mathew Louis Steven Leigh, "Transfer of lipophilic drugs between liposomal membranes and biological interfaces: Consequences for drug delivery", Eur. J. Pharm. Sci., 26 (3-4), 251-65 (2005)

33. Klemen Bohinc, Ales Iglic and Sylvio May, "Self-assembly of linear aggregates on curved membranes", Europhys. Lett., 71 (1), 145-151 (2005)

32. Assaf Zemel, Avinoam Ben-Shaul and Sylvio May, "Perturbation of a lipid membrane by amphipathic peptides and its role in pore formation", Eur. Biophys. J., 34: 230-243 (2005)

31. Emmanuel C. Mbamala, Avinoam Ben-Shaul, and Sylvio May, "Domain Formation Induced by the Adsorption of Charged Proteins on Mixed Lipid Membranes", Biophys. J., 88: 1702-1714 (2005)

30. Klemen Bohinc, Ales Iglic and Sylvio May, "Interaction between Macroions Mediated by Divalent Rod-like Ions", Europhys. Lett., 68 (4), 494-500 (2004)

29. Sylvio May, Yoni Kozlovsky, Avinoam Ben-Shaul and Misha Kozlov, "Tilt modulus of a lipid monolayer",, Eur.Phys.J.E, 14, 299-308 (2004)

28. Cristina Luminita Baciu and Sylvio May, "Stability of charged, mixed lipid bilayers: Effects of electrostatic coupling between the monolayers", J.Phys. Condens Matter, 16 S2455-S2460 (2004)

27. Assaf Zemel, Avinoam Ben-Shaul and Sylvio May, "Membrane Perturbation Induced by Interfacially Adsorbed Peptides", Biophys. J., 86, 3607-3619 (2004)

26. Sylvio May and Avinoam Ben-Shaul, "Modeling of cationic lipid-DNA complexes", Current Medicinal Chemistry, 11, 1241-1253 (2004)

25. Miha Fosnaric, Veronika Kralj-Iglic, Klemen Bohinc, Ales Igic and Sylvio May, "Stabilization of Pores in Lipid Bilayers by Anisotropic Inclusions", J.Phys.Chem.B, 107(45), 12519-12526 (2003)

24. Klemen Bohinc, Veronika Kralj-Iglic and Sylvio May, "Interaction between two cylindrical inclusions in a symmetric lipid bilayer", J.Chem.Phys., 119(14), 7435-7444 (2003)

23. Daniel Harries, Sylvio May and Avinoam Ben-Shaul, "Curvature and charge modulations in lamellar DNA-lipid complexes", J.Phys.Chem.B, 107(15), 3624-3630 (2003)

22. Sylvio May and Avinoam Ben-Shaul, "Membrane-Macromolecule Interactions and their Structural Consequences", Chapter 10 in "Membrane Science and Technology, Vol. 7: Planar Lipid Bilayers (BLMs) and their Applications", edited by H.T.Tien and A.Ottova-Leitmannova, Elsevier, 2003, pages 315-346

21. Sylvio May, Daniel Harries and Avinoam Ben-Shaul, "Macroion-induced compositional instability of binary fluid membranes", Phys.Rev.Lett., 89, 268102 (2002)

20. Sylvio May, "Structure and energy of fusion stalks: The role of membrane edges", Biophys. J., 83, 2969-2980 (2002)

19. Sylvio May, "Membrane Perturbations Induced by Integral Proteins: Role of Conformational Restrictions of the Lipid Chains" Langmuir 18(16), 6356-6364 (2002)

18. Daniel Harries, Sylvio May and Avinoam Ben-Shaul, "Adsorption of Charged Macromolecules on Mixed Fluid Membranes", Colloids and Interfaces A, 208, 41-50 (2002)

17. Amit Kessel, Nir Ben-Tal and Sylvio May, "Interactions of Cholesterol with Lipid Bilayers: The Preferred Configuration and Fluctuations", Biophys. J., 81, 643-658 (2001)

16. Sylvio May and Avinoam Ben-Shaul, "Molecular Theory of the Sphere-to-Rod Transition and the Second CMC in Aqueous Micellar Solutions", J.Phys.Chem.B, 105, 630-640 (2001)

15. Sylvio May, "Theories on structural perturbations of lipid bilayers", Curr. Opin. Coll. Int. Sci., 5, 244-249 (2000)

14. Sylvio May and Avinoam Ben-Shaul, "A molecular model for lipid-mediated interaction between proteins in membranes", Phys. Chem. Chem. Phys, 2, 4494-4502 (2000)

13. Sylvio May, Daniel Harries and Avinoam Ben-Shaul, "Lipid Demixing and Protein-Protein Interactions in the Adsorption of Charged Proteins on Mixed Membranes", Biophys.J., 79, 1747-1760 (2000)

12. Sylvio May, "A molecular model for the line tension of lipid membranes", Eur.Phys.J, E, 3, 37-44 (2000)

11. Sylvio May, "Inclusion induced bilayer deformations: The lipid tilt degree of freedom", Eur.Biophys.J, 29, 17-28 (2000)

10. Markus Deserno, Christian Holm and Sylvio May, "Fraction of condensed counterions around a charged rod: Comparison of Poisson-Boltzmann theory and computer simulations", Macromolecules, 33, 199-205 (2000)

9. Sylvio May, Daniel Harries and Avinoam Ben-Shaul, "The Phase Behavior of Cationic Lipid-DNA Complexes", Biophys J., 78, 1681-1697 (2000)

8. K. Wagner, D. Harries, S. May, V. Kahl, J.O Radler and A. Ben-Shaul, "Direct evidence for counterion Release upon Cationic Lipid-DNA Condensation", Langmuir, 16, 303-306 (2000)

7. Sylvio May and Avinoam Ben-Shaul, "Molecular Theory of Lipid-Protein Interaction and the L-HII transition", Biophys.J., 76, 751-767 (1999)

6. Daniel Harries, Sylvio May, William Gelbart and Avinoam Ben-Shaul, "Structure, Stability and Thermodynamics of Lamellar DNA-Lipid Complexes", Biophys.J., 75, 159-173 (1998)

5. Sylvio May and Avinoam Ben-Shaul, "DNA-Lipid Complexes: Stability of Honeycomb-like and Spaghetti-like Structures" Biophys.J. 73, 2427-2440 (1997),

4. Sylvio May , Yardena Bohbot and Avinoam Ben-Shaul, "Molecular Theory of Bending Elasticity and Branching of Cylindrical Micelles", J.Phys.Chem. B, 101, 8648-8657 (1997)

3. Sylvio May, "Curvature elasticity and thermodynamic stability of electrically charged membranes", J.Chem.Phys. 105, 8314 (1996)

2. Sylvio May and Avinoam Ben-Shaul, "Spontaneous curvature and thermodynamic stability of mixed amphiphilic layers", J.Chem.Phys. 103, 3839 (1995)

1. Sylvio May, "Position of the neutral surface in charged monolayers", Progr. Colloid. Polym. Sci. 97, 9-11 (1994)

h-factor: 31 (based on Web of Science)



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-- PHYS 120

-- Fundamentals of Physics



-- Spring

-- PHYS 120

-- Fundamentals of Physics



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-- Heat and Thermodynamics



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-- PHYS 212

-- College Physics II



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-- PHYS 455

-- Classical Mechanics


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