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Schedule and Course Topics

September 4,6,18,20,22 No class
August 31, September 14,28 @ 4:00pm Make-up classes; 65 minute sessions
Week 1, 2017

History of Genetics and Genomics

September 1, 2017 Genomics vocabulary: Assignment due
McClean

Whole Genome Sequencing: DNA structure; Clone-based vs. shotgun sequencing, Assembly of sequences (McClean)

Readings

McClean

Genome Annotation: Gene number, Categories of functional genes, Distribution of sequence classes, SNP and STS discovery (McClean)

Readings

McClean

Comparative Genomics: Common features of genomes, Genomic features specific to individual species, Genomic features shared by bacterial genomes, Genomic features shared by eukaryotic genomes, Variation among eukaryotic genomes, Genome evolution (McClean)

October 11, 2017 In-class review for exam
October 13, 2017 Exam 1
Li

Functional Genomics: Forward and reverse genetics, tools used, methods employed to identify the genes of interest
Gene Expression: Large scale expression studies, RNA-seq and other methods; Expression study designs, Appropriate controls
Epigenetic Modification: Profile epigenetic modifications and their role in gene expression and regulation

Meinhardt

Proteomes: Protein structure and functions, Protein isolation and characterization, Biochemical approaches to studying protein-protein interactions, Computational approaches to studying protein-protein interactions, Applications (Meinhardt)

November 23, 2017 No Class (Thanksgiving Holiday)
December 11, 2017

Exam 2, 10:30am