Introduction In situ Hybridization Human-Rodent Somatic Cell Hybrids Recombination Mapping of Meiotic Chromosomes Fine Structure Mapping of Chromosomes Map-based or Positional Cloning of Genes Study Questions Genomic Analysis WWW Links Genetic Topics

Study Questions What is the long term of genomic analysis? Describe flourescence in situ hybridization and its application in the analysis of human diseases. Determine upon which chromosome markers A, B and C reside. Marker Hybrid Line Chromosomes A B C 1 3,4,8,20 + - + 2 3,6,11,19 - + + 3 1,6,19,20 + - - What are the advantages of using VNTRs and microsattelites as molecular markers? How are STS used to construct contig maps? Describe in general the steps of mapped-based or positional cloning. Copyright © 1997. Phillip McClean