Introduction to Quantitative Genetics

Estimating Offspring Phenotype

To estimate the offspring phenotype from the cross of two parents selected from a base population you need several population parameters.

T = population mean
TF = mother phenotypic value
TM = fathers phenotypic value
T* = midparent value = (TF + TM)/2
h2 = narrow sense heritability estimate
To = predicted offspring value

Formula for predicted offspring value: To = T + h2(T* - T)

If TF = IQ of 120 and TM = IQ of 110, then

T* = (120 + 110)/2 = 115

How do the parents deviate from the population?

T*- T = 115- 100 = 15

How much of this deviation is heritable?

h2(T* - T) = 0.4(15) = 6

How will the offspring deviate from the population?

To = T + h2 (T* - T) = 100 + 6 = IQ of 106

This is the estimate of the offspring phenotype.