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Lecture series to feature talk on protein inhibitors, cancer

The NDSU Department of Pharmaceutical Sciences has invited David Weber, professor of biochemistry and molecular biology and director of the University of Maryland's Center for Biomolecular Therapeutics, to give a presentation as part of the Pharmaceutical Sciences Research Lecture Series. 

Weber's presentation, “Restoration of p53 tumor suppression in malignant melanoma,” is scheduled Monday, Dec. 7, at 1:30 p.m. in Sudro Hall, room 26.

Weber’s research focuses on the structure, function and inhibition of proteins, enzymes and other biological complexes. One set of his ongoing projects examines the structure, dynamics and function of S100 proteins, including those involved in cancer progression and metastases. As part of the project, Weber’s laboratory discovered S100 proteins inhibitor, SBi1 (pentamidine) that has advanced to a Phase 2 clinical trial.

The principal techniques used in Weber's research are nuclear magnetic resonance, X-ray crystallography and other biophysical tools. His research is supported by the National Institutes of Health.

Weber serves several National Institutes of Health study sections and he is an honorary faculty member at the University of Perugia, Italy. He earned his doctorate at the University of North Carolina, Chapel Hill, and received post-doctoral training at Johns Hopkins School of Medicine.

The seminar is open to everyone interested in biomedical research. For further information, contact Jagdish Singh at 701-231-7943.

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