Research Interest(s):

Bioinorganic Chemistry

Heme proteins play an important role in many biological processes. Three types of heme proteins are under inves-tigation in my research. The first class includes proteins like heme-binding protein A which is important in heme sequestering in Haemophilus influenzae. The second class is catalase-peroxidases, in particular, Mycobacterium tuberculosis KatG which is necessary for the activation of the antitubercular drug isonazid against tuberculosis. The third class is heme-based sensor proteins which are responsible for monitoring the presence of small mole-cules (like O₂, CO or NO) and initiating the appropriate response. Spectroscopic techniques, like resonance Raman, UV-visible absorbance and electron spin resonance, along with reaction kinetics, followed by transient absorbance, are used to probe the structure function relationships in these various heme proteins.

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