Sathish Venkatachalem, PhD

Associate Professor
108A Sudro Hall
Office Phone: 701.231.6371
Lab Phone: 701.231.8106

S.Venkatachalem@ndsu.edu 


Teaching

Chemotherapeutic/Infectious Disease Pharmacodynamics (PSCI 412) and Pharmacogenomics (PSCI 417) for Pharm D students.

Education

1999-2003, PhD, Biochemistry, University of Madras, Chennai, India           

1997-1999, MSc, Biochemistry, Bharathiar University, Coimbatore, India

1994-1997, BSc, Biochemistry, University of Madras, Chennai, India

Research Interests

The research laboratory of Dr. Venkatachalem, studies human lung diseases such as asthma, chronic obstructive pulmonary disease, lymphangioleiomyomatosis (LAM) disease and pulmonary hypertension. With reference to asthma, incidence and severity is higher in both pre-menopausal women and in aging men, suggesting a role for female sex steroids (estrogen) in modulating this disease. However, it is not clear whether and how estrogens impact the airway. Furthermore, women may be biologically more susceptible to cigarette smoke exposure than men when it comes to incidence of and complications from smoking-related airway diseases. Our studies using human airway smooth muscles from both male and female asthmatics vs. non-asthmatics, smokers vs. Non-smokers along with animal studies where we control sex steroids levels or their signaling will substantially enhance our understanding of how and why estrogens influence the asthmatic airway. In addition, LAM disease almost exclusively affects women. The mechanistic basis of gender specific LAM progression is still not well understood. We believe our focused studies will yield novel mechanistic information on LAM pathogenesis. Relevant sex storied signaling, studies regarding breast cancer and nanomedicine based drug delivery towards clinical translational research also of interest of the lab with collaborative fashion. Dr. Venkatachalem’s laboratory is supported by multiple research grants, including an NIH/NHLBI, NIH/NIGMS R01’s, ND Corn utilization council and ND EPSCoR grants.


Academic and Professional Appointments

2020-Present
Associate Professor
Department of Pharmaceutical Sciences,
North Dakota State University, Fargo, ND, USA

2021- Present 
Co-Director of COBRE, Administrative Core
Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer
North Dakota State University, Fargo, USA

2018- Present Co-Director 
Pilot project core Dakota cancer collaborative on translational activity (DaCCoTA) North Dakota    

2017-present, WOC Scientist
Veterans Affairs Hospital, Fargo

2016-present, Adjunct Assistant Professor of Physiology
Mayo Clinic, Rochester, MN, USA

2016-2018, Adjunct Faculty
JSS University, Karnataka, India

2016-2020, Assistant Professor
Department of Pharmaceutical Sciences, North Dakota State University, Fargo

2016, Associate Consultant
Mayo Clinic, Rochester, MN, USA

2012-2016, Assistant Professor of Physiology
Mayo Clinic, Rochester, MN, USA

2007, Research Associate
Departments of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA

2003-2006, Postdoctoral Research Associate
Heart Failure Research Group, Dept. of Physiology and Pharmacology, University of Western Ontario, London, Canada

Honors/Awards

2021, Manuscript selected for APS Select Award 2021 by the American Physiological Society
2020, Dean’s Award for excellence in Research, College of Health Professions
2020, Manuscript selected for APS Select Award 2020 by the American Physiological Society
2018, Experimental Biology and Medicine (EBM) outstanding Reviewer Award
2018, Experimental Biology and Medicine (EBM) outstanding Reviewer Award
2018, American Physiological Society Research Host for USRF program
2017, Impact Fund Award, NDSU Foundation and Alumni Association at Fargo, ND, USA
2016, Rising stars of Research Award in ATS Science and Innovation Center at American Thoracic Society, San Francisco, USA
2014, First place on the Best poster competition in 13th Scientific Symposium of the Flight Attendant Medical Research Institute (FAMRI), Miami, FL, USA 
2013, Dr. Duane K Rorie award for excellence in laboratory based research by the Department of Anaesthesiology, Mayo Clinic, MN, USA
2013, First place on the Best poster competition in 12th Scientific Symposium of the Flight Attendant Medical Research Institute (FAMRI), Miami, FL, USA 
2013-2016, Young Clinical Scientist Award – Faculty Flight Attendants Medical Research Institute (FAMRI), USA  
2011-2012, Young Clinical Scientist Award – Fellow Flight Attendants Medical Research Institute (FAMRI), USA
2009, Dr. Duane K Rorie award for excellence in laboratory based research by the Department of Anaesthesiology, Mayo Clinic, MN, USA 
2003-2006, Postdoctoral Research Fellowship - Heart and Stroke Foundation of Ontario program grant in Heart Failure, Canada.
2002-2003, Awarded Senior Research Fellowship - Council of Scientific and Industrial

Professional Society Memberships

2018-present, American Society of Pharmacology and Experimental Therapeutics (ASPET) - Member 
2018-present, Society for Experimental Biology and Medicine
2015-present, American Physiological Society - Member
2011-present, American Thoracic Society – Member
2009-2011, North American Vascular Biology Organization –Training Member
2007-2012, American Physiological Society – Member  

Journal Editorial Boards:

Frontiers in Physiology – Review Editor
JSM Biochemistry & Molecular Biology- Associate Editor
International Journal of Pulmonology and Clinical Research - Editorial Board
Mediators of Inflammation- Served as an invited Lead Guest Editor 

Ad hoc Reviewer:

Frontiers in Physiology, Translational Research, Molecular and Cellular Endocrinology, Experimental Lung Research, Journal of Cellular and Molecular Medicine, American Journal of Physiology Lung Cellular and Molecular Physiology, Journal of Liquid Chromatography & Related Technologies, Biomedical Research International, Life Sciences, Cellular Physiology and Biochemistry,  American Journal of Physiology Heart and Circulatory Physiology, Archives of Medical Science, Molecular and Cellular Biochemistry, Molecular Biology International, Lung, Trials in Vaccinology, Gene, American Journal of Physiology- Endocrine,  Scientific Reports, Chinese Journal of Physiology, Journal of Molecular Cell Biology, Clinical Sciences, Respiratory Research, BMC Physiology, Experimental Biology and Medicine, Archives of Biochemistry and Biophysics, Journal of Cellular Physiology, FASEB BioAdvances and Frontiers in Pharmacology, Archives of Microbiology, International Journal of Molecular Sciences, Cell and Tissue Research

Recent Publications 

Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt Jr. RD, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci. Rep. 2021 (In press).

Bhallamudi S, Roos BB, Teske JJ, Wicher SA, McConico A, M Pabelick C, Sathish V, Prakash YS. Glial-derived neurotrophic factor in human airway smooth muscle. J Cell Physiol. 2021 (In Press).

Borkar NA, Roos B, Prakash YS, Sathish V, Pabelick CM. Nicotinic α7 acetylcholine receptor (α7nAChR) in human airway smooth muscle. Arch Biochem Biophys. 2021; 706:108897.

Pang L, Shah H, Qian SY, Sathish V. Iminodibenzyl redirected cyclooxygenase-2 catalyzed dihomo-γ-linolenic acid peroxidation pattern in lung cancer. Free Radical Biology and Medicine. 2021; S0891-5849 (21) 00356-7

*Kalidhindi RS, *Ambhore NS, Balraj P, Schmit T, Khan MN, Sathish V. Androgen receptor activation alleviates airway hyperresponsiveness, inflammation and remodeling in a murine model of asthma. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2021; 320(5):L803-L818.

Sadiq M, Pang L, Johnson M, Sathish V, Zang Q, Wang M. 2D Nanomaterial, Ti3C2 MXene-based sensor to guide lung cancer therapy and management. Biosensors (Basel). 2021; 11(2):40.

Mamnoon B, Loganathan J, Confeld M, De Fonseka  N, Feng L, Froberg J, Choi Y, Tuvin  DM, Sathish V, Mallik S. Targeted polymeric nanoparticles for drug delivery to hypoxic, triple-negative breast tumors. ACS Applied Biomaterials. 2021; 4 (2):1450-1460.

*Kalidhindi RSR, *Borkar NA, *Ambhore NS, Pabelick CM, Prakash YS, Sathish V. Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19? Am J Physiol Lung Cell Mol Physiol. 2020; 319(5):L843-L847.

Shah H, Pang L, Wang H, Shu D, Qian SY, Sathish V. Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional delta-5-desaturase siRNA nanoparticle for breast cancer therapy. Nanomedicine. 2020; 30:102298.

Mamnoon B, Feng L, Froberg J, Choi Y, Sathish V, Mallik S. Hypoxia-Responsive, Polymeric Nanocarriers for Targeted Drug Delivery to Estrogen Receptor-Positive Breast Cancer Cell Spheroids. Mol Pharm. 2020 Nov 2;17(11):4312-4322.

Pang L, Shah H, Wang H, Shu D, Qian SY, Sathish V. EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation Molecular therapyNucleic Acids. 2020; 22: 222-235.

*Kalidhindi RSR, *Ambhore NS, Bhallamudi S, Loganathan J, Sathish V. Role of Estrogen Receptors α and β in a Murine Model of Asthma: Exacerbated Airway Hyperresponsiveness and Remodeling in ERβ Knockout Mice. Front Pharmacol. 2020 Feb 4;10:1499.

Bhallamudi S, Connell J, Pabelick CM, Prakash YS, Sathish V. Estrogen receptors differentially regulate intracellular calcium handling in human non-asthmatic and asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L112-L124.

Ambhore NS, Kalidhindi RSR, Pabelick CM, Hawse JR, Prakash YS, Sathish V. Differential estrogen-receptor activation regulates extracellular matrix deposition in human airway smooth muscle remodeling via NF-κB pathway. FASEB J. 2019 Dec;33(12):13935-13950.

Kalidhindi RSR, Katragadda R, Beauchamp KL, Pabelick CM, Prakash YS, Sathish V. Androgen Receptor-Mediated Regulation of Intracellular Calcium in Human Airway Smooth Muscle Cells. Cell Physiol Biochem. 2019;53(1):215-228.

*Ambhore NS, *Kalidhindi RSR, Loganathan J, Sathish V. Role of Differential Estrogen Receptor Activation in Airway Hyperreactivity and Remodeling in a Murine Model of Asthma. Am J Respir Cell Mol Biol. 2019 Oct;61(4):469-480.

Loganathan J, Pandey R, Ambhore NS, Borowicz P, Sathish V. Laser-capture microdissection of murine lung for differential cellular RNA analysis. Cell Tissue Res. 2019 Jun;376(3):425-432.

Kolumam Parameswaran P, Dai D, Ding YH, Urban MW, Manlove L, Sathish V, Cebral JR, Kallmes DF, Kadirvel R. Downstream vascular changes after flow-diverting device deployment in a rabbit model. J Neurointerv Surg. 2019 May;11(5):523-527.

Ambhore NS, Katragadda R, Raju Kalidhindi RS, Thompson MA, Pabelick CM, Prakash YS, Sathish V. Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation. Mol Cell Endocrinol. 2018 Nov 15;476:37-47.

Habib A, Sathish V, Mallik S, Khoda B. 3D Printability of Alginate-Carboxymethyl Cellulose Hydrogel. Materials (Basel). 2018;11(3), pii: E454.

Aravamudan B, Goorhouse KJ, Unnikrishnan G, Thompson MA, Pabelick CM, Hawse JR, Prakash YS, Sathish V. Differential Expression of Estrogen Receptor Variants in response flammation Signals in Human Airway Smooth Muscle. Journal of Cellular Physiology. 2017;232(7), 1754-60.

Freeman MR, Sathish V, Manlove L, Wang S, Britt RD, Thompson MA, Pabelick CM, Prakash YS. Brain Derived neurotropic factor and Airway fibrosis in asthma. Am J Physiol Lung Cell Mol Physiol. 2017;313, L360-70.

Wang S, Sathish V, Freeman MR, Thompson MA, Pabelick CM, Prakash YS. Secreted BDNF asthma severity. Am J Respir Cell Mol Biol. 2016;54(2), 297.

Wang S, Freeman MR, Sathish V, Thompson MA, Pabelick CM, Prakash YS. 2016. Sex Steroids Influence Brain-Derived Neurotropic Factor Secretion from Human Airway Smooth Muscle Cells. Journal of Cellular Physiology 231, 1586-92.

Sathish V, Martin YN, Prakash YS. Sex steroid signaling: implications for lung diseases. Pharmacology and Therapeutics. 2015;150, 94-108.

*Yarova PL, *Stewart A, *Sathish V, *Britt Jr RD, Thompson MA, Lowe APP, et al. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine. 2015;7(284), 284ra60.

Hartman WT, Helan M, Smelter DF, Sathish V, et al. Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle. PloS one. 2015;10 (7), e0129489.

**Sathish V, Freeman MR, Long E, Thompson MA, Pabelick CM, Prakash YS. Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle. Cellular Physiology and Biochemistry 2015;36(3), 1101-15.

Wylam ME, Sathish V, VanOosten SK, Freeman M, Burkholder D, Thompson MA, et al. Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle. PloS one. 2015;10(6), e0128778.

Marudamuthu AS, Shetty SK, Bhandary YP, Karandashova S, Thompson M, Sathish V, et al. Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrosis lungs. Journal of Biological Chemistry. 2015;290(15), 9428-41.

Marudamuthu AS, Bhandary YP, Shetty SK, Fu J, Sathish V, Prakash Y, et al. Role of the Urokinase-Fibrinolytic System in Epithelial-Mesenchymal Transition during Lung Injury. American Journal of Pathology 2015;185(1), 55-68.

Sathish V, Thompson MA, Sinha S, Sieck GC, Prakash YS, Pabelick CM. Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle. Biochimica et Biophysica Acta. 2014;1843(2), 346-51.

Vohra PK, Thompson MA, Sathish V, Kiel A, Jerde C, Pabelick CM, et al. 2013. TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle. Biochimica et Biophysica Acta 1833(12), 2953-60.

Sathish V, Vanoosten SK, Miller BS, Aravamudan B, Thompson MA, Pabelick CM, et al. 2013. Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivity. American Journal of Respiratory Cell and Molecular Biology 48(4), 431-8.

Townsend EA, Sathish V, Thompson MA, Pabelick CM, Prakash YS. 2012. Estrogen effects on human airway smooth muscle involve cAMP and protein kinase A. American Journal of Physiology Lung Cellular and Molecular Physiology 303(10), L923-8.

Sathish V, Abcejo AJ, Thompson MA, Sieck GC, Prakash YS, Pabelick CM. 2012. Caveolin-1 regulation of store-operated Ca2+ influx in human airway smooth muscle. European Respiratory Journal 40(2), 470-8.

Hartman WR, Smelter DF, Sathish V, Karass M, Kim S, Aravamudan B, et al. 2012. Oxygen dose responsiveness of human fetal airway smooth muscle cells. American Journal of Physiology Lung Cellular and Molecular Physiology 303(8), L711-9.

Grim KJ, Abcejo AJ, Barnes A, Sathish V, Smelter DF, Ford GC, et al. 2012. Caveolae and propofol effects on airway smooth muscle. British journal of anesthesia 109(3), 444-53.

Abcejo AJ, Sathish V, Smelter DF, Aravamudan B, Thompson MA, Hartman WR, et al. 2012. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PloS one 7(8), e44343.

Sathish V, Yang B, Meuchel LW, VanOosten SK, Ryu AJ, Thompson MA, et al. 2011. Caveolin-1 and force regulation in porcine airway smooth muscle. American Journal of Physiology Lung Cellular and Molecular Physiology 300(6), L920-9.

Sathish V, Delmotte PF, Thompson MA, Pabelick CM, Sieck GC, Prakash YS. 2011. Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle. PloS one 6(8), e23662.

Sathish V, Abcejo AJ, Vanoosten SK, Thompson MA, Prakash YS, Pabelick CM. 2011. Caveolin-1 in cytokine-induced enhancement of intracellular Ca2+ in human airway smooth muscle. American Journal of Physiology Lung Cellular and Molecular Physiology 301(4), L607-14.

Smelter DF, *Sathish V, Thompson MA, Pabelick CM, Vassallo R, Prakash YS. 2010. Thymic stromal lymphopoietin in cigarette smoke-exposed human airway smooth muscle. Journal of Immunology 185(5), 3035-40.

Sathish V, Thompson MA, Bailey JP, Pabelick CM, Prakash YS, Sieck GC. 2009. Effect of proinflammatory cytokines on regulation of sarcoplasmic reticulum Ca2+ reuptake in human airway smooth muscle. American Journal of Physiology Lung Cellular and Molecular Physiology 297(1), L26-34.

Prakash YS, Sathish V, Thompson MA, Pabelick CM, Sieck GC. 2019. Asthma and Sarcoplasmic Reticulum Ca2+ Reuptake in Airway Smooth Muscle. American Journal of Physiology Lung Cellular and Molecular Physiology 297(4), L794.

Sathish V, Leblebici F, Kip SN, Thompson MA, Pabelick CM, Prakash YS, et al. 2008. Regulation of sarcoplasmic reticulum Ca2+ reuptake in porcine airway smooth muscle. American Journal of Physiology Lung Cellular and Molecular Physiology 294 (4): L787-96.

Senthilkumar S EK, Sathish V, Yogeeta S, Devaki T. 2007. Modulation of the tissue defense system by squalene in cyclophosphamide-induced toxicity in rats. Archives of Medical Science 2(2), 94-100.

Gnanapragasam A, Yogeeta S, Subhashini R, Ebenezar KK, Sathish V, Devaki T. 2007. Adriamycin induced myocardial failure in rats: protective role of Centella asiatica. Molecular Cellular Biochemistry 294(1-2), 55-63.

Geoghegan-Morphet N, Burger D, Lu X, Sathish V, Peng T, Sims SM, et al. 2017. Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes. Cardiovascular Research 75(2), 408-16.

Sathish V, Xu A, Karmazyn M, Sims SM, Narayanan N. 2006. Mechanistic basis of differences in Ca2+ -handling properties of sarcoplasmic reticulum in right and left ventricles of normal rat myocardium. American Journal of Physiology-Heart and Circulatory Physiology 291(1), H88-96.

Gnanapragasam A, Ebenezar KK, Sathish V, Govindaraju P, Devaki T. 2004. Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats. Life Sciences 76(5), 585-97.

Sathish V, Ebenezar KK, Devaki T. 2003. Biochemical changes on the cardioprotective effect of nicorandil and amlodipine during experimental myocardial infarction in rats. Pharmacological Research 48(6), 565-70.

Sathish V, Ebenezar KK, Devaki T. 2003. Synergistic effect of Nicorandil and Amlodipine on tissue defense system during experimental myocardial infarction in rats. Molecular Cellular Biochemistry 243(1-2), 133-8.

Sathish V, Ebenezar KK, Devaki T. 2003. Synergistic effect of nicorandil and amlodipine on lysosomal hydrolases during experimental myocardial infarction in rats. Biomedicine and Pharmacotherapy 57(7), 309-13.

Ebenezar KK, Sathish V, Devaki T. 2003. Effect of arginine and lysine on mitochondrial function during isoproterenol induced myocardial infarction in rats. Nutrition Research 23(9), 1269-77.

Ebenezar KK, Sathish V, Devaki T.2003. Effect of oral administration of L-arginine and L-lysine on lipid metabolism against isoproterenol-induced myocardial infarction in rats. Journal of Clinical Biochemistry and Nutrition 33(1), 7-11.

Ebenezar KK, Sathish V, Devaki T. 2003. Effect of L-arginine and L-lysine on lysosomal hydrolases and membrane bound phosphatases in experimentally induced myocardial infarction in rats. Molecular Cellular Biochemistry 247(1-2), 163-9.

Sathish V, Vimal V, Ebenezar KK, Devaki T. 2002. Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats. Journal of Pharmacy and Pharmacology 54(1), 133-7.

Ebenezar KK, Sathish V, Devaki T. 2001. Protective role of arginine and lysine on tissue defense system during isoproterenol induced myocardial stress in rats. Biomedicine 21(2-3), 71-6.

Book chapters:

Sathish V and Prakash YS.  Sex Differences in Pulmonary Anatomy and Physiology: Implications for Health and Disease. In: Neigh GN and Mitzefelt MM, editors. Sex Differences in Physiology: Academic Press; 2016: p. 89-103.

Prakash YS, Sathish V, Townsend E. Sex Steroid Signaling in the Airway. In: Wang Y-X, editor. Calcium Signaling in Airway Smooth Muscle Cells: Springer International Publishing; 2014. p. 321-32.

Borkar NA and Sathish V. Sex steroids and their influence in lung disease across the lifespan. In: Silveyra P and Xenia T, editors. Sex-Based Differences in Lung Physiology: Springer International Publishing; 2021: p. 39-72 (Springer/APS/NIH supported).

Roos B, *Teske J, Bhallamudi S, Pabelick CM, Sathish V, Prakash YS. Neurotrophin regulation and signaling in airway smooth muscle. Adv Exp Med Biol. 2021; 1304:109-121 (Springer Book Series).

*Ambhore NS, *Kalidhindi RSR, Sathish V. Sex steroid signaling in lung diseases and inflammation. Adv Exp Med Biol. 2021; 1303: 243-273 (Springer Book Series).

*Kalidhindi RS, *Ambhore NS, Sathish V. Cellular and biochemical analysis of bronchoalveolar lavage fluid from murine. Methods in Molecular Biology. 2021; 2223:201-215 (Springer Book Series).


*Equal Contribution
**Senior Author

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