The Fillmore Lab studies how energy metabolism contributes to metabolic diseases such as type II diabetes and cardiovascular disease, particularly in heart and skeletal muscle. To develop strategies to treat these diseases, the Fillmore Lab works to understand the regulation of metabolism and its role in disease.
- Understand the mechanisms by which energy metabolism regulates insulin resistance
- Elucidate the mechanisms by which of fatty acid signaling regulates cardiac hypertrophy and function.
- Explore the mechanisms involved in the crosstalk between the heart and the metabolism of systemic tissues
Fillmore Lab funding
1401 Albrecht Boulevard, Fargo, ND 58102
NDSU Dept. 2660 / PO Box 6050 / Fargo, ND 58108-6050
Fillmore Lab news
Fillmore N, Hou V, Sun J, Springer D, Murphy E. Cardiac specific knock-down of peroxisome proliferator activated receptor α prevents fasting-induced cardiac lipid accumulation and reduces perilipin 2. PLoS One. 2022 Mar 8;17(3):e0265007.